Human Anti-GPRC5D scFv-Fc Chimera (VS-0325-FY36) (CAT#: VS-0325-FY36)
The anti-GPRC5D scFv-Fc antibody targets GPRC5D, a G-protein coupled receptor with emerging roles in cancer and immune regulation. It is constructed with a scFv-Fc format to provide high specificity and prolonged activity in vivo. This antibody holds promise for therapeutic applications in cancers such as multiple myeloma, where GPRC5D is a novel target.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human pancreas
(Immunohistochemical staining of human pancreas shows moderate cytoplasmic positivity in islets of Langerhans.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/71909/157845_A_2_3_selected.jpg
(Immunohistochemical staining of human pancreas shows moderate cytoplasmic positivity in islets of Langerhans.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/71909/157845_A_2_3_selected.jpg
Figure 2 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/71909/157845_B_9_5.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/71909/157845_B_9_5.jpg
Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/71909/157845_A_7_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/71909/157845_A_7_3.jpg
Figure 4 Rectum
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/71909/157845_A_4_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/71909/157845_A_4_3.jpg
Figure 5 Liver
(Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/71909/157845_A_9_4.jpg
(Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/71909/157845_A_9_4.jpg
Figure 6 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/71909/157845_A_8_5.jpg
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/71909/157845_A_8_5.jpg
Figure 7 Testis
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/71909/157845_A_4_6.jpg
(Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/71909/157845_A_4_6.jpg
Figure 8 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/71909/157845_A_8_8.jpg
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/71909/157845_A_8_8.jpg
Figure 9 RNA cell line category: Group enriched (Karpas-707, RPMI-8226, U-266/84)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000111291-GPRC5D
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000111291-GPRC5D
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human GPRC5D
- Species Reactivity
- Human
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- G Protein-Coupled Receptor Class C Group 5 Member D; G Protein-Coupled Receptor, Family C, Group 5, Member D; G Protein-Coupled Receptor, Class C, Group 5, Member D
- Gene ID
- 55507
- UniProt ID
- Q9NZD1
- Long Name
- G Protein-Coupled Receptor Class C Group 5 Member D
- Sequence Similarities
- Belongs to the G-protein coupled receptor 3 family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- XP_016875072.1; XP_054228435.1; XP_054228436.1; NP_061124.1
- Function
- GPRC5D (G protein-coupled receptor class C group 5 member D) is a receptor found predominantly on plasma cells and is associated with multiple myeloma. It plays a role in cell signaling and is a target for novel cancer therapies. Its expression pattern makes it valuable in the context of targeted cancer treatments.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1396MZ | Recombinant Mouse Anti-Human GPRC5D Antibody | WB | Mouse antibody |
| VS4-WK201 | Human Anti-GPRC5D Recombinant Antibody (clone 3D4) | ELISA | Human IgG |
| VS-0723-WK42 | Human Anti-GPRC5D Recombinant Antibody (clone Talquetamab) | FC | Human IgG4 |
| VS-0723-WK277 | Rabbit Anti-GPRC5D Recombinant Antibody (VS-0723-WK277) | ELISA, FC | Rabbit IgG |
| VS-0723-WK282 | Rabbit Anti-GPRC5D Recombinant Antibody (VS-0723-WK282) | ELISA, FC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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