Human Anti-GRIN2B (clone 2) scFv-Fc Chimera (CAT#: VS-0325-FY98)
The anti-NMDAR2B scFv-Fc antibody targets the NMDAR2B subunit of the NMDA receptor, a key molecule in synaptic plasticity and neurotransmission. It has potential therapeutic applications in neurological disorders, such as epilepsy and neurodegenerative diseases. The scFv-Fc format enhances its stability and bioavailability, making it suitable for prolonged therapeutic use.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human cerebellum
(Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/ihc_selected.jpg
(Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/ihc_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/154297_B_9_5.jpg
(Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/154297_B_9_5.jpg
Figure 3 Cerebellum
(Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/154297_B_7_8.jpg
(Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/154297_B_7_8.jpg
Figure 4 RNA cell line category: Cell line enhanced (CACO-2, NTERA-2, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000273079-GRIN2B
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000273079-GRIN2B
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human GRIN2B
- Species Reactivity
- Human
- Clone
- clone 2
- Applications
- Inhibition
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Glutamate Ionotropic Receptor NMDA Type Subunit 2B; Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B; Glutamate [NMDA] Receptor Subunit Epsilon-2; N-Methyl D-Aspartate Receptor Subtype 2B; N-Methyl-D-Aspartate Receptor Subunit 3; NMDAR2B; GluN2B; NR2B
- Gene ID
- 2904
- UniProt ID
- Q13224
- Long Name
- Glutamate Ionotropic Receptor NMDA Type Subunit 2B
- Sequence Similarities
- Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily.
- Cellular Localization
- Cell membrane; Postsynaptic cell membrane; Late endosome; Lysosome; Cytoplasm, cytoskeleton
- Post Translation Modifications
- Phosphorylated on tyrosine residues (By similarity).
Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity (By similarity).
Glycosylation at Asn74, Asn341, Asn348, Asn444, Asn491, Asn542, and Asn688
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen
- Protein Refseq
- XP_005253408.1; XP_054227829.1; XP_054227830.1; XP_054227831.1; NP_000825.2
- Function
- GRIN2B (Glutamate ionotropic receptor NMDA type subunit 2B) is a subunit of the NMDA receptor, crucial for synaptic plasticity, learning, and memory. It plays a vital role in neuronal signaling and is implicated in neurological disorders.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "GRIN2B"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products
Rabbit Monoclonal Antibody Products
Non-Human Primate (NHP) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2170MZ | Recombinant Mouse Anti-Human GRIN2B Antibody (clone 24B22) | ICC, IHC-G, WB | Mouse antibody |
| FAMAB-1390CQ | Mouse Anti-Grin2b Recombinant Antibody (clone 17) | ELISA | Mouse IgG1 |
| VS-0522-LC194 | Mouse Anti-GRIN2B Recombinant Antibody (VS-0522-LC194) | ICC, IP, KO/KD-WB, WB, IF, IHC | Mouse IgG2a |
| VS-0522-LC195 | Rat Anti-GRIN2B Recombinant Antibody (VS-0522-LC195) | ICC, IP, KO/KD-WB, WB, IF, IHC | Rat IgG2b |
| VS-0522-LC196 | Human Anti-GRIN2B Recombinant Antibody (VS-0522-LC196) | ICC, IP, KO/KD-WB, WB, IF, IHC | Human IgG1 |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0325-FY98. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: FuncS, Inhib, IP, ELISA
-YJ-1.jpg)
Application: ELISA
Application: ELISA, IHC, FC, WB, IF, IA
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
