Human Anti-GRIN2B (clone 2) scFv-Fc Chimera
CAT#: VS-0325-FY98
The anti-NMDAR2B scFv-Fc antibody targets the NMDAR2B subunit of the NMDA receptor, a key molecule in synaptic plasticity and neurotransmission. It has potential therapeutic applications in neurological disorders, such as epilepsy and neurodegenerative diseases. The scFv-Fc format enhances its stability and bioavailability, making it suitable for prolonged therapeutic use.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human cerebellum
Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/154297_B_9_5.jpg
Normal Tissue
Figure 3 Cerebellum
Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/154297_B_7_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (CACO-2, NTERA-2, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000273079-GRIN2B
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human GRIN2B
- Species Reactivity
- Human
- Clone
- clone 2
- Applications
- Inhibition
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Glutamate Ionotropic Receptor NMDA Type Subunit 2B; Glutamate Receptor, Ionotropic, N-Methyl D-Aspartate 2B; Glutamate [NMDA] Receptor Subunit Epsilon-2; N-Methyl D-Aspartate Receptor Subtype 2B; N-Methyl-D-Aspartate Receptor Subunit 3; NMDAR2B; GluN2B; NR2B
- Gene ID
- 2904
- UniProt ID
- Q13224
- Long Name
- Glutamate Ionotropic Receptor NMDA Type Subunit 2B
- Sequence Similarities
- Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2B/GRIN2B subfamily.
- Cellular Localization
- Cell membrane; Postsynaptic cell membrane; Late endosome; Lysosome; Cytoplasm, cytoskeleton
- Post Translation Modifications
- Phosphorylated on tyrosine residues (By similarity).
Phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity (By similarity).
Glycosylation at Asn74, Asn341, Asn348, Asn444, Asn491, Asn542, and Asn688
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen
- Protein Refseq
- XP_005253408.1; XP_054227829.1; XP_054227830.1; XP_054227831.1; NP_000825.2
- Function
- GRIN2B (Glutamate ionotropic receptor NMDA type subunit 2B) is a subunit of the NMDA receptor, crucial for synaptic plasticity, learning, and memory. It plays a vital role in neuronal signaling and is implicated in neurological disorders.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
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- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "GRIN2B"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2170MZ | Recombinant Mouse Anti-Human GRIN2B Antibody (clone 24B22) | ICC, IHC-G, WB | Mouse antibody |
| VS-0522-LC194 | Mouse Anti-GRIN2B Recombinant Antibody (VS-0522-LC194) | ICC, IP, KO/KD-WB, WB, IF, IHC | Mouse IgG2a |
| VS-0522-LC195 | Rat Anti-GRIN2B Recombinant Antibody (VS-0522-LC195) | ICC, IP, KO/KD-WB, WB, IF, IHC | Rat IgG2b |
| VS-0522-LC196 | Human Anti-GRIN2B Recombinant Antibody (VS-0522-LC196) | ICC, IP, KO/KD-WB, WB, IF, IHC | Human IgG1 |
| VS-0522-LC197 | Rabbit Anti-GRIN2B Recombinant Antibody (VS-0522-LC197) | ICC, IP, KO/KD-WB, WB, IF, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1512 | Rabbit Anti-GRIN2B Recombinant Antibody (clone DS1512AB) | FC, WB, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY344 | Mouse Anti-NHP GRIN2B Recombinant Antibody (clone B3-13B11) | WB, IHC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC700 | Recombinant Anti-Grin2b Vesicular Antibody, EV Displayed (VS-0425-YC700) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2923 | Anti-GRIN2B Immunohistochemistry Kit | IHC | |
| VS-0525-XY2924 | Anti-Mouse GRIN2B Immunohistochemistry Kit | IHC |
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