Human Anti-HAVCR2 scFv-Fc Chimera (VS-0325-FY3)
CAT#: VS-0325-FY3
The anti-HAVCR2 single-chain variable fragment (scFv) fused to the Fc region of an antibody is designed to specifically target the HAVCR2 molecule, also known as Tim-3 (T-cell immunoglobulin and mucin domain 3). HAVCR2 is a protein that plays a significant role in immune regulation and is involved in the exhaustion of T-cells in various chronic diseases, including cancer and viral infections.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_A_9_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_A_9_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_A_5_6.jpg
Normal Tissue
Figure 5 High expression in lymph node.
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_A_8_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, Daudi, HDLM-2, HMC-1, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135077-HAVCR2
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human HAVCR2
- Species Reactivity
- Human
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Hepatitis A Virus Cellular Receptor 2; T-Cell Immunoglobulin And Mucin Domain-Containing Protein 3; T-Cell Immunoglobulin Mucin Family Member 3; T-Cell Immunoglobulin Mucin Receptor 3; T-Cell Membrane Protein 3; HAVcr-2; TIMD-3; Tim-3
- Gene ID
- 84868
- UniProt ID
- Q8TDQ0
- Long Name
- Hepatitis A Virus Cellular Receptor 2
- Sequence Similarities
- Belongs to the immunoglobulin superfamily.
- Cellular Localization
- Membrane; Cell junction; Cell membrane
- Post Translation Modifications
- O-glycosylated with core 1 or possibly core 8 glycans.
Phosphorylated on tyrosine residues; modestly increased after TCR/CD28 stimulation.
Can be phosphorylated in the cytoplasmatic domain by FYN (By similarity).
Phosphorylation at Tyr-265 is increased by stimulation with ligand LGALS9.
Glycosylation at Thr145 and Asn172
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect HAVR2_HUMAN (712)
Glycosylation from GlyGen 4 sites, 6 O-linked glycans (3 sites)
- Protein Refseq
- NP_116171.3
- Function
- Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005).
In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion.
The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, 26492563).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| HPAB-1047LY-S(P) | Human Anti-HAVCR2 Recombinant Antibody; scFv Fragment (HPAB-1047LY-S(P)) | ELISA | Human scfv |
| HPAB-1048LY-S(P) | Human Anti-HAVCR2 Recombinant Antibody; scFv Fragment (HPAB-1048LY-S(P)) | ELISA | Human scfv |
| HPAB-1049LY-S(P) | Human Anti-HAVCR2 Recombinant Antibody; scFv Fragment (HPAB-1049LY-S(P)) | ELISA | Human scfv |
| HPAB-1050LY-S(P) | Human Anti-HAVCR2 Recombinant Antibody; scFv Fragment (HPAB-1050LY-S(P)) | ELISA | Human scfv |
| HPAB-1051LY-S(P) | Human Anti-HAVCR2 Recombinant Antibody; scFv Fragment (HPAB-1051LY-S(P)) | ELISA | Human scfv |
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