Human Anti-HAVCR2 scFv-Fc Chimera (VS-0325-FY3) (CAT#: VS-0325-FY3)
The anti-HAVCR2 single-chain variable fragment (scFv) fused to the Fc region of an antibody is designed to specifically target the HAVCR2 molecule, also known as Tim-3 (T-cell immunoglobulin and mucin domain 3). HAVCR2 is a protein that plays a significant role in immune regulation and is involved in the exhaustion of T-cells in various chronic diseases, including cancer and viral infections.
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Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_B_9_5.jpg
(Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_B_9_5.jpg
Figure 2 Colon
(Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_A_9_3.jpg
(Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_A_9_3.jpg
Figure 3 Kidney
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_A_9_5.jpg
(Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_A_9_5.jpg
Figure 4 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_A_5_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_A_5_6.jpg
Figure 5 High expression in lymph node.
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_A_8_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26003/54545_A_8_8.jpg
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, Daudi, HDLM-2, HMC-1, RPMI-8226)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135077-HAVCR2
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135077-HAVCR2
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human HAVCR2
- Species Reactivity
- Human
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Hepatitis A Virus Cellular Receptor 2; T-Cell Immunoglobulin And Mucin Domain-Containing Protein 3; T-Cell Immunoglobulin Mucin Family Member 3; T-Cell Immunoglobulin Mucin Receptor 3; T-Cell Membrane Protein 3; HAVcr-2; TIMD-3; Tim-3
- Gene ID
- 84868
- UniProt ID
- Q8TDQ0
- Long Name
- Hepatitis A Virus Cellular Receptor 2
- Sequence Similarities
- Belongs to the immunoglobulin superfamily.
- Cellular Localization
- Membrane; Cell junction; Cell membrane
- Post Translation Modifications
- O-glycosylated with core 1 or possibly core 8 glycans.
Phosphorylated on tyrosine residues; modestly increased after TCR/CD28 stimulation.
Can be phosphorylated in the cytoplasmatic domain by FYN (By similarity).
Phosphorylation at Tyr-265 is increased by stimulation with ligand LGALS9.
Glycosylation at Thr145 and Asn172
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect HAVR2_HUMAN (712)
Glycosylation from GlyGen 4 sites, 6 O-linked glycans (3 sites)
- Protein Refseq
- NP_116171.3
- Function
- Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005).
In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion.
The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits, and/or LGALS9-dependent recruitment of PTPRC to the immunological synapse (PubMed:24337741, 26492563).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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