Human Anti-HIV-1 Env (clone PGT121) scFv-Fc Chimera
CAT#: VS-0125-FY69
The anti-HIV-1 scFv-Fc antibody targets the envelope protein of HIV-1, specifically the epitope crucial for the virus's ability to invade host cells. By binding to specific HIV-1 antigens, these antibodies can neutralize the virus and prevent it from infecting cells. The main role of the anti-scFv-Fc antibody is to neutralize HIV-1, effectively blocking its capacity to infect host cells. In comparison to traditional full-length IgG antibodies, the single-chain design addresses issues related to the mismatch between heavy and light chains, improving expression efficiency and usability. Moreover, the scFv-Fc structure facilitates universal binding to the Fc fragment, which helps extend its half-life in the body.
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human immunodeficiency virus (HIV)
- Clone
- PGT121
- Applications
- Neutralization
- Related Disease
- HIV infection
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The anti-scFv-Fc antibody has the potential to effectively neutralize the HIV-1 virus, thereby preventing it from infecting host cells. Its single-chain structure design may address the challenge of heavy and light chain mismatch typically associated with traditional full-length IgG, which can enhance antibody expression efficiency and broaden its applications. Furthermore, the scFv-Fc format is capable of binding universally to the Fc fragment, potentially prolonging its half-life in the body.
Target
- Alternative Names
- HIV-1 env glycoprotein; Human immunodeficiency virus-1 Glycoprotein
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| MRO-2745CQ-S(P) | Human Anti-HIV-1 Env Recombinant Antibody scFv Fragment (MRO-2745CQ-S(P)) | Neut | Human scFv |
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| CAT | Product Name | Application | Type |
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| MRO-2743CQ-F(E) | Human Anti-HIV-1 Env Recombinant Antibody (clone 6.1C); Fab Fragment | ELISA | Human Fab |
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| MRO-2745CQ-F(E) | Human Anti-HIV-1 Env Recombinant Antibody Fab Fragment (MRO-2745CQ-F(E)) | Neut | Human Fab |
| MRO-2746CQ-F(E) | Human Anti-HIV-1 Env Recombinant Antibody Fab Fragment (MRO-2746CQ-F(E)) | Neut | Human Fab |
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