Human Anti-HIV-1 p24 (clone 183-H12-5C) scFv-Fc Chimera (CAT#: VS-0125-FY66)
The target of the anti-scFv-Fc is the HIV-1 p24 protein, which is a component of the HIV virus structure responsible for maintaining the integrity and structure of the viral particles. This study successfully constructed three expression plasmids encoding scFv 183-H12-5C and a modified scFv-Fc (a fusion protein of scFv and the human IgG1 Fc fragment). These recombinant antibodies were successfully expressed in HEK293 cells and their specific binding ability was verified through ELISA and Western blot. Additionally, the molecular weight of scFv is approximately 29 kDa, while the molecular weight of scFv-Fc is approximately 52 kDa.
Specific Inquiry
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human immunodeficiency virus (HIV)
- Clone
- 183-H12-5C
- Applications
- ELISA, Inhibition
- Related Disease
- HIV infection
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The main function of this antibody is to recognize and bind to the HIV-1 p24 protein, thereby inhibiting HIV replication. Studies have shown that Jurkat T cells transfected with pCDNA3.3-scFv 183-H12-5C can inhibit the replication of the NL4-3 virus, demonstrating a certain level of anti-HIV activity and its potential as an antibody.
Target
- Alternative Names
- HIV-1 P24; Human immunodeficiency virus type 1
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Human Antibody Products
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Single Domain Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-186LC-S(P) | Anti-HIV-1 p24 Recombinant Antibody scFv Fragment (6A9/5) | ELISA | Human antibody |
| MRO-187LC-S(P) | Anti-HIV-1 p24 Recombinant Antibody scFv Fragment (6D9/4) | ELISA | Human antibody |
| MRO-188LC-S(P) | Anti-HIV-1 p24 Recombinant Antibody scFv Fragment (2E7/3) | ELISA | Human antibody |
| MRO-186LC-F(E) | Anti-HIV-1 p24 Recombinant Antibody Fab Fragment (6A9/5) | ELISA | Human antibody |
| MRO-187LC-F(E) | Anti-HIV-1 p24 Recombinant Antibody Fab Fragment (6D9/4) | ELISA | Human antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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