Human Anti-HIV gp120 (clone 2G12) scFv-Fc Chimera (CAT#: VS-0125-FY70)
The Anti-HIV gp120 2G12 scFv-Fc is a recombinant antibody fusion protein that combines a single-chain variable fragment (scFv) specific to the HIV envelope glycoprotein gp120 with an Fc region derived from an IgG antibody. This construct is designed to enhance antiviral activity by targeting the gp120 protein, which is critical for the HIV virus's ability to infect host cells.
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human immunodeficiency virus (HIV)
- Clone
- 2G12
- Applications
- Neutralization
- Related Disease
- HIV infection
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Although the 2G12 scFv-Fc theoretically possesses good targeting abilities, its N-glycosylation pattern, secretion pathway, and stability issues in plant cell expression significantly impact its functional performance. This research provides important insights for the future optimization of recombinant antibody design.
Target
- Alternative Names
- Human immunodeficiency virus; HIV; Envelope glycoprotein GP120; gp120; HIV envelope
- Gene ID
- 155971
- UniProt ID
- P04578
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgM Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| DrMAB-136 | Human Anti-HIV gp120 Recombinant Antibody (clone HGD65) | Neut | Human IgG1, λ |
| MOB-412 | Recombinant Anti-HIV gp120 Antibody | ELISA, WB, Dot, FuncS | IgG |
| MHH-412 | Recombinant Human Anti-HIV gp120 Antibody | WB, Dot, FuncS | IgG |
| HPAB-1859-FY | Human Anti-HIV gp120 Recombinant Antibody (clone pMT4-3) | Neut | Human IgG |
| FAMAB-0080WJ | Human Anti-HIV gp120 Recombinant Antibody (clone NO.13) | ELISA, WB | Human IgG1, λ |
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