Human Anti-hla (clone MEDI4893) scFv-Fc Chimera (CAT#: VS-0325-FY151)
The Anti-α-Hemolysin scFv-Fc antibody is a promising new tool with potential research, diagnostic, and therapeutic applications. This antibody specifically targets α-hemolysin (α-HL), a key virulence factor of S. aureus, and exhibits high specificity towards this toxin, showing binding to S. aureus but not to S. albicans. The scFv-Fc format, consisting of a single-chain variable fragment fused to the Fc region of human IgG, provides advantages such as increased serum half-life and the potential for effector functions.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Specifications
- Immunogen
- The immunogen was purified α-hemolysin protein.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- High specificity towards α-HL. The antibody showed specific binding to S. aureus but not to S. albicans.
- Species Reactivity
- S. aureus
- Clone
- MEDI4893
- Applications
- ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- hla, alpha-toxin; Staphylococcus aureus alpha-hemolysin
- Long Name
- Staphylococcus aureus alpha-hemolysin
- Function
- Staphylococcus aureus hla (alpha-hemolysin) is a pore-forming toxin that damages host cell membranes. It contributes to bacterial virulence and is implicated in various staphylococcal infections.
Recommended Products
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Human Antibody Products
IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-358CL | Anti-Human Hla Recombinant Antibody (TAB-358CL) | FuncS, Neut | Antibody |
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