Human Anti-IFNG (clone BS-A) scFv-Fc Chimera
CAT#: VS-0425-FY40
The anti-IFNG scFv-Fc is a targeted therapeutic protein developed to recognize and neutralize interferon-gamma (IFNG), a key cytokine involved in immune response regulation. This product is engineered with a single-chain variable fragment (scFv) linked to an Fc domain, which improves its stability and therapeutic efficacy. By inhibiting IFNG, the scFv-Fc may help to alleviate excessive inflammatory responses and potentially benefit patients with autoimmune diseases. With its high specificity, the anti-IFNG scFv-Fc is suitable for various research and therapeutic applications. The protein undergoes extensive quality control measures to ensure purity and functionality. This innovative approach aims to provide a novel solution for controlling IFNG-related pathologies.
Gene Expression
Normal Tissue
Figure 1 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10344/26961_A_8_3.jpg
RNA Expression
Figure 2 RNA cell line category: Not detected
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000111537-IFNG
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IFNG
- Species Reactivity
- Human
- Clone
- BS-A
- Applications
- Neutralization, ELISA
- Related Disease
- Immunodeficiency 69; Hepatitis C Virus
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interferon Gamma
- Gene ID
- 3458
- UniProt ID
- P01579
- Long Name
- Interferon Gamma
- Cellular Localization
- Secreted
- Post Translation Modifications
- Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
Glycosylation at Asn48 and Asn120
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect IFNG_HUMAN (287)
Glycosylation from GlyGen 3 sites, 41 N-linked glycans (1 site)
- Protein Refseq
- NP_000610.2
- Function
- Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.
Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation.
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Related Diseases
Inflammatory Bowel Diseases
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Primary Immunodeficiency
Maturity Onset Diabetes of the Young
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
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| NEUT-1014CQ | Mouse Anti-IFNG Recombinant Antibody (clone D9D10) | Block, FC, ELISA, WB | Mouse IgG1 |
| NEUT-1033CQ | Mouse Anti-IFNG Recombinant Antibody (clone SN-6) | ELISA, Block | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1018CQ | Mouse Anti-IFNG Recombinant Antibody (clone NIB42) | ELISA, Neut, IP, RIA | Mouse IgG1 |
| NEUT-1019CQ | Mouse Anti-Ifng Recombinant Antibody (clone CBL981) | ELISA, Neut, WB | Mouse IgG1 |
| NEUT-1020CQ | Rat Anti-Ifng Recombinant Antibody (NEUT-1020CQ) | IHC-Fr, Neut | Rat IgG1 |
| NEUT-1021CQ | Rat Anti-Ifng Recombinant Antibody (clone R4-6A2) | ELISA, IHC, IHC-Fr, Neut, WB | Rat IgG1 |
| NEUT-1022CQ | Rat Anti-Ifng Recombinant Antibody (clone XMG1.2) | Neut | Rat IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1742 | Rabbit Anti-IFNG Recombinant Antibody (clone DS1742AB) | WB | Rabbit IgG |
| MOR-4228 | Rabbit Anti-IFNG Recombinant Antibody (clone SI307DS) | FC | Rabbit IgG |
| MOR-4600 | Rabbit Anti-IFNG Recombinant Antibody (clone TH113DS) | WB | Rabbit IgG |
| MOR-4601 | Rabbit Anti-IFNG Recombinant Antibody (clone TH114DS) | WB | Rabbit IgG |
| MOR-4602 | Rabbit Anti-Ifng Recombinant Antibody (clone TH115DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0882LC | Mouse Anti-IFNG Recombinant Antibody (clone MIF3009) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0040-YC-F(E) | Human Anti-IFNG Recombinant Antibody; Fab Fragment (HPAB-0040-YC-F(E)) | Neut | Human Fab |
| HPAB-0041-YC-F(E) | Human Anti-IFNG Recombinant Antibody; Fab Fragment (HPAB-0041-YC-F(E)) | Neut | Human Fab |
| HPAB-0042-YC-F(E) | Human Anti-IFNG Recombinant Antibody; Fab Fragment (HPAB-0042-YC-F(E)) | ELISA, Neut | Human Fab |
| FAMAB-0162-CN-F(E) | Human Anti-IFNG Recombinant Antibody (clone 41ms4G); Fab Fragment | ELISA | Human Fab |
| FAMAB-0163-CN-F(E) | Human Anti-IFNG Recombinant Antibody (clone 57-5); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0162-CN | Human Anti-IFNG Recombinant Antibody (clone 41ms4G) | ELISA | Human IgG |
| FAMAB-0163-CN | Human Anti-IFNG Recombinant Antibody (clone 57-5) | ELISA | Human IgG |
| FAMAB-0164-CN | Human Anti-IFNG Recombinant Antibody (clone 36-4) | ELISA | Human IgG |
| FAMAB-0165-CN | Human Anti-IFNG Recombinant Antibody (clone 44ms4) | ELISA | Human IgG |
| FAMAB-0166-CN | Human Anti-IFNG Recombinant Antibody (clone 13ms5F) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0162-CN-S(P) | Human Anti-IFNG Recombinant Antibody (clone 41ms4G); scFv Fragment | ELISA | Human scFv |
| FAMAB-0163-CN-S(P) | Human Anti-IFNG Recombinant Antibody (clone 57-5); scFv Fragment | ELISA | Human scFv |
| FAMAB-0164-CN-S(P) | Human Anti-IFNG Recombinant Antibody (clone 36-4); scFv Fragment | ELISA | Human scFv |
| FAMAB-0165-CN-S(P) | Human Anti-IFNG Recombinant Antibody (clone 44ms4); scFv Fragment | ELISA | Human scFv |
| FAMAB-0166-CN-S(P) | Human Anti-IFNG Recombinant Antibody (clone 13ms5F); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| VS-0525-XY3414 | Anti-Zebrafish IFNG Immunohistochemistry Kit | IHC | |
| VS-0525-XY3413 | Anti-Rat IFNG Immunohistochemistry Kit | IHC |
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