Human Anti-IFNG (clone BS-A) scFv-Fc Chimera (CAT#: VS-0425-FY40)
The anti-IFNG scFv-Fc is a targeted therapeutic protein developed to recognize and neutralize interferon-gamma (IFNG), a key cytokine involved in immune response regulation. This product is engineered with a single-chain variable fragment (scFv) linked to an Fc domain, which improves its stability and therapeutic efficacy. By inhibiting IFNG, the scFv-Fc may help to alleviate excessive inflammatory responses and potentially benefit patients with autoimmune diseases. With its high specificity, the anti-IFNG scFv-Fc is suitable for various research and therapeutic applications. The protein undergoes extensive quality control measures to ensure purity and functionality. This innovative approach aims to provide a novel solution for controlling IFNG-related pathologies.
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Normal Tissue
RNA Expression
Figure 1 Colon
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10344/26961_A_8_3.jpg
(Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10344/26961_A_8_3.jpg
Figure 2 RNA cell line category: Not detected
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000111537-IFNG
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000111537-IFNG
Figure 2 RNA cell line category: Not detected
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000111537-IFNG
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000111537-IFNG
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IFNG
- Species Reactivity
- Human
- Clone
- BS-A
- Applications
- Neutralization, ELISA
- Related Disease
- Immunodeficiency 69; Hepatitis C Virus
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interferon Gamma
- Gene ID
- 3458
- UniProt ID
- P01579
- Long Name
- Interferon Gamma
- Cellular Localization
- Secreted
- Post Translation Modifications
- Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
Glycosylation at Asn48 and Asn120
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect IFNG_HUMAN (287)
Glycosylation from GlyGen 3 sites, 41 N-linked glycans (1 site)
- Protein Refseq
- NP_000610.2
- Function
- Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation.
Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation.
Related Resources
Inflammatory Bowel Diseases
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Primary Immunodeficiency
Maturity Onset Diabetes of the Young
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-090 | Recombinant Anti-human IFNG VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| TAB-140CT | Anti-Human IFN-γ Single Domain Antibody (TAB-140CT), Research Grade Biosimilar | ELISA | Single domain antibody |
| TAB-141CT | Anti-Human IFN-γ Single Domain Antibody (TAB-141CT), Research Grade Biosimilar | ELISA | Single domain antibody |
| TAB-142CT | Anti-Human IFN-γ Single Domain Antibody (TAB-142CT), Research Grade Biosimilar | ELISA | Single domain antibody |
| TAB-143CT | Anti-Human IFN-γ Single Domain Antibody (TAB-143CT), Research Grade Biosimilar | ELISA | Single domain antibody |
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For Research Use Only. Not For Clinical Use.
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