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    Human Anti-IGF1R (clone 1H3) scFv-Fc Chimera (CAT#: VS-0125-FY20)

    Anti-insulin-like growth factor-1 receptor single-chain variable fragment-Fc fusion protein (anti-IGF-IR scFv-Fc) is a fusion protein that combines a single-chain antibody with an Fc region, targeting the insulin-like growth factor-1 receptor (IGF-IR). IGF-IR is a receptor closely associated with the proliferation and anti-apoptotic properties of various cancer cells. Its specific function is to promote cell proliferation and inhibit apoptosis by binding to IGF-I and IGF-II. Anti-IGF-IR scFv-Fc offers high specificity and affinity, making it useful for research and potential therapeutic applications, especially in the treatment of IGF-IR-related cancers.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 Cerebral cortex
    Figure 1 Cerebral cortex
    (Endothelial cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Glial cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Neuronal cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Neuropil
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_7_5.jpg
    Figure 2 Colon
    Figure 2 Colon
    (Endothelial cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Glandular cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_3.jpg
    Figure 3 Liver
    Figure 3 Liver
    (Cholangiocytes
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Hepatocytes
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_8_4.jpg
    Figure 4 Kidney
    Figure 4 Kidney
    (Cells in glomeruli
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Cells in tubules
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_5.jpg
    Figure 5 Testis
    Figure 5 Testis
    (Cells in seminiferous ducts
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Leydig cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_6_6.jpg
    Figure 6 Heart muscle
    Figure 6 Heart muscle
    (Cardiomyocytes
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_5_6.jpg
    Figure 7 Lymph node
    Figure 7 Lymph node
    (Germinal center cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Non-germinal center cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_8.jpg
    RNA Expression
    Figure 8 RNA cell line category: Low cell line specificity
    Figure 8 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R
    Figure 8 RNA cell line category: Low cell line specificity
    Figure 8 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R

    Specifications

    • Host Species
    • Human
    • Type
    • Human IgG1, scFv-Fc
    • Species Reactivity
    • Human
    • Clone
    • 1H3
    • Applications
    • ELISA, Flow Cytometry, Neutralization, Inhibition
    • Related Disease
    • Cancer

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Format
    • Liquid
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Buffer
    • PBS
    • Preservative
    • No preservatives
    • Stabilizer
    • No Stabilizers
    • Sterility
    • 0.2 μM filtered
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • Anti-IGF-IR scFv-Fc offers high specificity and affinity, making it valuable for research and potential therapeutic applications, particularly in the treatment of IGF-IR-related cancers. The application of this technology contributes to a deeper understanding of the role of the insulin-like growth factor pathway in tumorigenesis and provides new strategies for targeted therapies.

    Target

    • Alternative Names
    • Insulin Like Growth Factor 1 Receptor
    • Sequence Similarities
    • Belongs to the protein kinase superfamily.
    • Cellular Localization
    • Cell membrane
    • Post Translation Modifications
    • Autophosphorylated on tyrosine residues in response to ligand binding.
      Autophosphorylation occurs in trans, i.e.
      one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit.
      Autophosphorylation occurs in a sequential manner; Tyr-1165 is predominantly phosphorylated first, followed by phosphorylation of Tyr-1161 and Tyr-1166.
    • Function
    • Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1).
      Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity.
      The activated IGF1R is involved in cell growth and survival control.
      IGF1R is crucial for tumor transformation and survival of malignant cell.

    Recommended Products

    Secondary Antibody

    Isotype Control

    Related Resources

    • Related Signaling Pathways
    • Related Diseases

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "Clone 1H3"

    See other products for "IGF1R"

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    CAT Product Name Application Type
    NABL-091 Recombinant Anti-human IGF1R VHH Single Domain Antibody WB, ELISA, IHC, FC, FuncS Llama VHH
    TAB-096ZJ Anti-Human IGF-1R Single Domain Antibody (TAB-096ZJ), Research Grade Biosimilar ELISA, IHC, IF, WB Single domain antibody
    HPAB-1545-FY Recombinant Llama Anti-IGF1R Single Domain Antibody (HPAB-1545-FY) WB, ELISA Llama VHH
    HPAB-1546-FY Recombinant Llama Anti-IGF1R Single Domain Antibody (HPAB-1546-FY) WB, ELISA Llama VHH
    HPAB-1547-FY Recombinant Llama Anti-IGF1R Single Domain Antibody (HPAB-1547-FY) WB, ELISA Llama VHH

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