Human Anti-IGF1R (clone 1H3) scFv-Fc Chimera

Name: Human Anti-IGF1R (clone 1H3) scFv-Fc Chimera
SKU: VS-0125-FY20
Rating: 5 (1 reviews)

CAT#: VS-0125-FY20

Anti-insulin-like growth factor-1 receptor single-chain variable fragment-Fc fusion protein (anti-IGF-IR scFv-Fc) is a fusion protein that combines a single-chain antibody with an Fc region, targeting the insulin-like growth factor-1 receptor (IGF-IR). IGF-IR is a receptor closely associated with the proliferation and anti-apoptotic properties of various cancer cells. Its specific function is to promote cell proliferation and inhibit apoptosis by binding to IGF-I and IGF-II. Anti-IGF-IR scFv-Fc offers high specificity and affinity, making it useful for research and potential therapeutic applications, especially in the treatment of IGF-IR-related cancers.

Gene Expression

Normal Tissue Figure 1 Cerebral cortex

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_7_5.jpg

Normal Tissue Figure 2 Colon

Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_3.jpg

Normal Tissue Figure 3 Liver

Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_8_4.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_5.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_6_6.jpg

Normal Tissue Figure 6 Heart muscle

Cardiomyocytes
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_B_5_6.jpg

Normal Tissue Figure 7 Lymph node

Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/10268/32662_A_7_8.jpg

RNA Expression Figure 8 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000140443-IGF1R

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Specifications

Host Species
Human

Type
Human IgG1, scFv-Fc

Species Reactivity
Human

Clone
1H3

Applications
ELISA, Flow Cytometry, Neutralization, Inhibition

Related Disease
Cancer

Product Property

Purity
>95% as determined by SDS-PAGE

Format
Liquid

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Stabilizer
No Stabilizers

Sterility
0.2 μM filtered

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Shipping
Ice packs

Applications

Application Notes
Anti-IGF-IR scFv-Fc offers high specificity and affinity, making it valuable for research and potential therapeutic applications, particularly in the treatment of IGF-IR-related cancers. The application of this technology contributes to a deeper understanding of the role of the insulin-like growth factor pathway in tumorigenesis and provides new strategies for targeted therapies.

Target

Alternative Names
Insulin Like Growth Factor 1 Receptor

Gene ID
3480

UniProt ID
P08069

Sequence Similarities
Belongs to the protein kinase superfamily.

Cellular Localization
Cell membrane

Post Translation Modifications
Autophosphorylated on tyrosine residues in response to ligand binding.
Autophosphorylation occurs in trans, i.e.
one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit.
Autophosphorylation occurs in a sequential manner; Tyr-1165 is predominantly phosphorylated first, followed by phosphorylation of Tyr-1161 and Tyr-1166.

Protein Refseq
XP_011519818.1; XP_011519819.1; XP_016877626.1; XP_047288398.1; XP_047288399.1

Function
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1).
Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity.
The activated IGF1R is involved in cell growth and survival control.
IGF1R is crucial for tumor transformation and survival of malignant cell.

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Related Signaling Pathways

Insulin Signaling Pathway

Related Diseases

Endocrine Resistance

Type I Diabetes Mellitus

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS-0125-FY20.pdf

MSDS

MSDS - VS-0125-FY20.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Secondary Antibody

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