Human Anti-IL10RA (clone 136C5) scFv-Fc Chimera
CAT#: VS-0325-FY25
An anti-IL10RA scFv-Fc antibody is a recombinant antibody that detects IL-10RA, a receptor for interleukin-10 (IL-10). The scFv-Fc format combines the antigen-binding capabilities of an scFv (single-chain variable fragment) with the stability and effector functions of an Fc (fragment crystallizable) region.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HDLM-2
Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/65647/1962_E9_3_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line K-562
Immunofluorescent staining of human cell line K-562 shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/69086/1993_G10_3_selected.jpg
RNA Expression
Figure 3 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, Karpas-707, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000110324-IL10RA
❮
❯
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL10RA
- Species Reactivity
- Human
- Clone
- 136C5
- Applications
- ELISA, Flow Cytometry, Blocking, Neutralization
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Interleukin 10 Receptor Subunit Alpha
- Gene ID
- 3587
- UniProt ID
- Q13651
- Long Name
- Interleukin 10 Receptor Subunit Alpha
- Sequence Similarities
- Belongs to the type II cytokine receptor family.
- Cellular Localization
- Cell membrane; Cytoplasm
- Post Translation Modifications
- Phosphorylated.
Phosphorylation of the cytoplasmic tail induced STAT3 activation.
Ubiquitinated by BTRC; ubiquitination leads to endocytosis and subsequent degradation of IL10RA.
Glycosylation at Asn50, Asn74, Asn110, Asn154, Asn177, and Asn189
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 6 sites
- Protein Refseq
- XP_047282838.1; XP_047282839.1; XP_047282840.1; XP_054224642.1; XP_054224643.1
- Function
- Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.
Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608).
In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952).
These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0325-FY25. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "IL10RA"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-550 | Recombinant Anti-human IL10RA Antibody | WB, ELISA, IHC, FuncS | IgG |
| MHH-550 | Recombinant Human Anti-human IL10RA Antibody | ELISA, WB, Neut, FuncS | IgG |
| MOB-0630CT | Recombinant Mouse anti-Human IL10RA Monoclonal antibody (48708.22) | ELISA, FC, Neut, WB | |
| HPAB-0276-CN | Human Anti-IL10RA Recombinant Antibody (HPAB-0276-CN) | ELISA, FC, Block, Neut | Human IgG1 |
| MOB-112LC | Rat Anti-IL10RA Recombinant Antibody (MOB-112LC), PE | FC | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-550-F(E) | Recombinant Anti-human IL10RA Antibody Fab Fragment | ELISA, RIA, FuncS | Fab |
| MHH-550-F(E) | Recombinant Human Anti-human IL10RA Antibody Fab Fragment | WB, IF, FuncS | Fab |
| HPAB-0276-CN-F(E) | Human Anti-IL10RA Recombinant Antibody; Fab Fragment (HPAB-0276-CN-F(E)) | ELISA, FC, Block, Neut | Human Fab |
| HPAB-0277-CN-F(E) | Human Anti-IL10RA Recombinant Antibody; Fab Fragment (HPAB-0277-CN-F(E)) | ELISA, FC, Block, Neut | Human Fab |
| HPAB-0278-CN-F(E) | Human Anti-IL10RA Recombinant Antibody; Fab Fragment (HPAB-0278-CN-F(E)) | ELISA, FC, Block, Neut | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-550-S(P) | Recombinant Anti-human IL10RA Antibody scFv Fragment | IF, FC, Biosensors, FuncS | scFv |
| MHH-550-S(P) | Recombinant Human Anti-human IL10RA Antibody scFv Fragment | WB, IF, FuncS | scFv |
| HPAB-0276-CN-S(P) | Human Anti-IL10RA Recombinant Antibody; scFv Fragment (HPAB-0276-CN-S(P)) | ELISA, FC, Block, Neut | Human scFv |
| HPAB-0277-CN-S(P) | Human Anti-IL10RA Recombinant Antibody; scFv Fragment (HPAB-0277-CN-S(P)) | ELISA, FC, Block, Neut | Human scFv |
| HPAB-0278-CN-S(P) | Human Anti-IL10RA Recombinant Antibody; scFv Fragment (HPAB-0278-CN-S(P)) | ELISA, FC, Block, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G039E | IL-10-PE immunotoxin | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1132CQ | Rat Anti-IL10RA Recombinant Antibody (clone 3F9) | FC, IP, Block | Rat IgG2a, κ |
| NEUT-1137CQ | Rat Anti-Il10ra Recombinant Antibody (NEUT-1137CQ) | Block, FC, IHC-Fr | Rat IgG2 |
| NEUT-1138CQ | Rat Anti-Il10ra Recombinant Antibody (clone 1B1.3A) | Block, FC, WB | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1133CQ | Mouse Anti-IL10RA Recombinant Antibody (clone CBL076) | WB, Neut | Mouse IgG2 |
| NEUT-1134CQ | Mouse Anti-IL10RA Recombinant Antibody (clone CBL463) | Neut | Mouse IgG1 |
| NEUT-1135CQ | Mouse Anti-IL10RA Recombinant Antibody (clone 7Q35) | Neut | Mouse IgG2 |
| NEUT-1136CQ | Mouse Anti-IL10RA Recombinant Antibody (clone 37607.11) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY126 | CytoStream™ Rat Anti-IL10RA Recombinant Antibody (clone 1B1.3a) | FC | Rat IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC589 | Recombinant Anti-IL10RA Vesicular Antibody, EV Displayed (VS-0425-YC589) | Block, ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3478 | Anti-IL10RA Immunohistochemistry Kit | IHC | |
| VS-0525-XY3479 | Anti-Mouse IL10RA Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: WB, IF, FuncS
-2-1.png)
Application: ELISA
Application: ELISA, IHC, FC, WB, IF, IA
Application: ELISA, FuncS
Application: ELISA, IF, Block, FuncS
Application: ELISA, FC, Neut, Inhib
Application: ELISA, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
