Human Anti-IL10RA (clone 136C5) scFv-Fc Chimera (CAT#: VS-0325-FY25)
An anti-IL10RA scFv-Fc antibody is a recombinant antibody that detects IL-10RA, a receptor for interleukin-10 (IL-10). The scFv-Fc format combines the antigen-binding capabilities of an scFv (single-chain variable fragment) with the stability and effector functions of an Fc (fragment crystallizable) region.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line HDLM-2
(Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65647/1962_E9_3_selected.jpg
(Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/65647/1962_E9_3_selected.jpg
Figure 2 IF staining of human cell line K-562
(Immunofluorescent staining of human cell line K-562 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69086/1993_G10_3_selected.jpg
(Immunofluorescent staining of human cell line K-562 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69086/1993_G10_3_selected.jpg
Figure 3 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, Karpas-707, RPMI-8226)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000110324-IL10RA
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000110324-IL10RA
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL10RA
- Species Reactivity
- Human
- Clone
- 136C5
- Applications
- ELISA, Flow Cytometry, Blocking, Neutralization
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Interleukin 10 Receptor Subunit Alpha
- Gene ID
- 3587
- UniProt ID
- Q13651
- Long Name
- Interleukin 10 Receptor Subunit Alpha
- Sequence Similarities
- Belongs to the type II cytokine receptor family.
- Cellular Localization
- Cell membrane; Cytoplasm
- Post Translation Modifications
- Phosphorylated.
Phosphorylation of the cytoplasmic tail induced STAT3 activation.
Ubiquitinated by BTRC; ubiquitination leads to endocytosis and subsequent degradation of IL10RA.
Glycosylation at Asn50, Asn74, Asn110, Asn154, Asn177, and Asn189
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 6 sites
- Protein Refseq
- XP_047282838.1; XP_047282839.1; XP_047282840.1; XP_054224642.1; XP_054224643.1
- Function
- Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation.
Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well (PubMed:16982608).
In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively (PubMed:12133952).
These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-550-F(E) | Recombinant Anti-human IL10RA Antibody Fab Fragment | ELISA, RIA, FuncS | Fab |
| MHH-550-F(E) | Recombinant Human Anti-human IL10RA Antibody Fab Fragment | WB, IF, FuncS | Fab |
| HPAB-0276-CN-F(E) | Human Anti-IL10RA Recombinant Antibody; Fab Fragment (HPAB-0276-CN-F(E)) | ELISA, FC, Block, Neut | Human Fab |
| HPAB-0277-CN-F(E) | Human Anti-IL10RA Recombinant Antibody; Fab Fragment (HPAB-0277-CN-F(E)) | ELISA, FC, Block, Neut | Human Fab |
| HPAB-0278-CN-F(E) | Human Anti-IL10RA Recombinant Antibody; Fab Fragment (HPAB-0278-CN-F(E)) | ELISA, FC, Block, Neut | Human Fab |
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