Human Anti-IL17RA scFv-Fc Chimera (VS-0425-FY41) (CAT#: VS-0425-FY41)

• Host Species
• Human

• Type
• Human IgG2, scFv-Fc

• Specificity
• Human IL17RA

• Species Reactivity
• Human

• Applications
• Western Blot, ELISA, Dot Blot

• Related Disease
• Asthma, Psoriasis, Crohn's Disease, Psoriatic Arthritis, and Rheumatoid Arthritis

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Western Blot: 2 μg/mL
  Dot Blot: 2 μg/mL
  The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Interleukin 17 Receptor A

• Gene ID
• 23765

• UniProt ID
• Q96F46

• Long Name
• Interleukin 17 Receptor A

• Cellular Localization
• Cell membrane, Secreted

• Post Translation Modifications
• Glycosylated.
  Glycosylation at Asn49, Asn54, Asn67, Asn206, Asn225, Asn242, and Asn265
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 8 sites, 10 N-linked glycans (4 sites), 1 O-linked glycan (1 site)

• Protein Refseq
• NP_001276834.1; NP_055154.3

• Function
• Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity.
  Receptor for IL17A.
  Receptor for IL17F.
  Binds to IL17A with higher affinity than to IL17F.
  Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC.
  Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC.
  Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation.
  Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi.

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