Human Anti-IL17RA scFv-Fc Chimera (VS-0425-FY41)
CAT#: VS-0425-FY41
The anti-IL17RA scFv-Fc is a novel therapeutic antibody designed to target the interleukin-17 receptor A (IL17RA), a key mediator in inflammatory responses. By binding specifically to IL17RA, this recombinant single-chain variable fragment fused with an IgG Fc domain helps to inhibit IL-17 signaling, which is implicated in various autoimmune conditions. The product is engineered for enhanced stability and longer half-life in circulation, making it a promising candidate for chronic disease treatment. Preclinical studies have demonstrated its potential to reduce inflammation and tissue damage in models of diseases such as psoriasis and rheumatoid arthritis. Additionally, its dual mechanism of action not only blocks IL-17 signaling but also modulates immune responses. The anti-IL17RA scFv-Fc represents a significant advancement in targeted therapies for inflammatory diseases.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24996/if_selected.jpg
Normal Tissue
Figure 2 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24996/59803_A_7_3.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24996/59803_A_7_4.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (HL-60, NB-4, THP-1)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000177663-IL17RA
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Specifications
- Host Species
- Human
- Type
- Human IgG2, scFv-Fc
- Specificity
- Human IL17RA
- Species Reactivity
- Human
- Applications
- Western Blot, ELISA, Dot Blot
- Related Disease
- Asthma, Psoriasis, Crohn's Disease, Psoriatic Arthritis, and Rheumatoid Arthritis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 2 μg/mL
Dot Blot: 2 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 17 Receptor A
- Gene ID
- 23765
- UniProt ID
- Q96F46
- Long Name
- Interleukin 17 Receptor A
- Cellular Localization
- Cell membrane, Secreted
- Post Translation Modifications
- Glycosylated.
Glycosylation at Asn49, Asn54, Asn67, Asn206, Asn225, Asn242, and Asn265
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 8 sites, 10 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001276834.1; NP_055154.3
- Function
- Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity.
Receptor for IL17A.
Receptor for IL17F.
Binds to IL17A with higher affinity than to IL17F.
Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC.
Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC.
Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation.
Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2670z | Mouse Anti-IL17RA Recombinant Antibody (clone 42A2) | WB, FC, Neut | Mouse IgG1 |
| MOB-019LC | Rat Anti-Il17ra Recombinant Antibody (clone YC125) | FC, FuncS | Rat IgG |
| HPAB-0318-WJ | Human Anti-IL17RA Recombinant Antibody (HPAB-0318-WJ) | ELISA, Neut | Humanized IgG |
| HPAB-0144-WJ | Human Anti-IL17RA Recombinant Antibody (HPAB-0144-WJ) | ELISA | Humanized IgG |
| VS-0723-WK267 | Rabbit Anti-IL17RA Recombinant Antibody (VS-0723-WK267) | ELISA, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-093 | Recombinant Anti-human IL17RA VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-134 | Human Anti-IL17RA Recombinant Antibody (TAB-134) | Neut, ELISA, IF, IP, FuncS, FC, ICC | Human IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-217 | Anti-Human IL17RA Recombinant Antibody (TAB-217) | WB, ELISA, FC, IP, FuncS, IF, Neut | IgG4 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1230CQ | Mouse Anti-IL17RA Recombinant Antibody (VMC192) | FuncS, Neut | Mouse IgG1, κ |
| NEUT-1231CQ | Mouse Anti-IL17RA Recombinant Antibody (VMC193) | Neut, WB | Mouse IgG1 |
| NEUT-1232CQ | Mouse Anti-IL17RA Recombinant Antibody (clone CBL538) | WB, FC, CyTOF, Neut | Mouse IgG1 |
| NEUT-1233CQ | Mouse Anti-IL17RA Recombinant Antibody (clone MM0371-8D15) | WB, Neut | Mouse IgG1 |
| NEUT-1234CQ | Rabbit Anti-IL17RA Recombinant Antibody (clone CBL999) | Neut | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1794 | Rabbit Anti-IL17RA Recombinant Antibody (clone DS1794AB) | WB, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-134 | Afuco™ Anti-IL17RA Recombinant Antibody (AFC-TAB-134), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | Human IgG1, κ |
| AFC-TAB-217 | Afuco™ Anti-IL17RA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-217) | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0318-WJ-S(P) | Human Anti-IL17RA Recombinant Antibody; scFv Fragment (HPAB-0318-WJ-S(P)) | ELISA, Neut | Humanized scFv |
| HPAB-0319-WJ-S(P) | Human Anti-IL17RA Recombinant Antibody; scFv Fragment (HPAB-0319-WJ-S(P)) | ELISA, Neut | Humanized scFv |
| HPAB-0320-WJ-S(P) | Human Anti-IL17RA Recombinant Antibody; scFv Fragment (HPAB-0320-WJ-S(P)) | ELISA, Neut | Humanized scFv |
| HPAB-0321-WJ-S(P) | Human Anti-IL17RA Recombinant Antibody; scFv Fragment (HPAB-0321-WJ-S(P)) | ELISA, Neut | Humanized scFv |
| HPAB-1557-FY-F(E) | Human Anti-IL17RA Recombinant Antibody; Fab Fragment (HPAB-1557-FY-F(E)) | FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0318-WJ-F(E) | Human Anti-IL17RA Recombinant Antibody; Fab Fragment (HPAB-0318-WJ-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0319-WJ-F(E) | Human Anti-IL17RA Recombinant Antibody; Fab Fragment (HPAB-0319-WJ-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0320-WJ-F(E) | Human Anti-IL17RA Recombinant Antibody; Fab Fragment (HPAB-0320-WJ-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0853-FY-S(P) | Human Anti-IL17RA Recombinant Antibody; scFv Fragment (HPAB-0853-FY-S(P)) | Activ | Human scFv |
| HPAB-0854-FY-S(P) | Human Anti-IL17RA Recombinant Antibody; scFv Fragment (HPAB-0854-FY-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC580 | Recombinant Anti-IL17RA Vesicular Antibody, EV Displayed (VS-0425-YC580) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3496 | Anti-IL17RA Immunohistochemistry Kit | IHC |
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