Human Anti-IL1R1 (clone 26F5) scFv-Fc Chimera
CAT#: VS-0125-FY73
This anti-IL1R1 scFv-Fc fusion protein demonstrates significant advantages in the rapid screening of antibody clones with excellent specificity, thereby enabling effective modulation of the IL-1 signaling pathway. It is considered a potential therapeutic antibody. The utility of scFv-Fc fusion proteins for the rapid screening of clones derived from phage libraries highlights their ability to identify promising antibody leads with therapeutic potential.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line ASC TERT1
Immunofluorescent staining of human cell line ASC TERT1 shows localization to nucleoplasm, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1237/1774_H4_18_cr5952945990756_selected.jpg
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- 26F5
- Applications
- Inhibition
- Related Disease
- Inflammation and joint injury
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The anti-scFv-Fc antibody can inhibit IL-1-induced NF-κB nuclear translocation by competitively binding to IL-1R1, potentially reducing inflammation and joint damage caused by IL-1. These antibodies have been shown in bioassays to significantly suppress IL-1-mediated signaling.
Target
- Alternative Names
- Interleukin 1 Receptor Type 1
- Gene ID
- 3554
- UniProt ID
- P14778
- Sequence Similarities
- Belongs to the interleukin-1 receptor family.
- Cellular Localization
- Membrane; Single-pass type I membrane protein
Cell membrane
Secreted
- Post Translation Modifications
- A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).
Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.
Glycosylation at Asn100, Asn193, Asn233, Asn249, Asn263, and Asn297
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 6 sites, 1 N-linked glycan (1 site)
- Protein Refseq
- XP_005263987.1; XP_005263991.1; XP_011509417.1; XP_011509418.1; XP_011509420.1
- Function
- After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways.
Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits.
Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.
Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "Clone 26F5"
- CAT
- Product Name
See other products for "IL1R1"
Select a product category from the dropdown menu below to view related products.
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-216CT | Anti-Human IL-1R1 (Interleukin 1 receptor type 1) Single Domain Antibody (TAB-216CT), Research Grade Biosimilar | Inhib | Single domain antibody |
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| CAT | Product Name | Application | Type |
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| NEUT-1293CQ | Hamster Anti-Il1r1 Recombinant Antibody (clone JAMA147) | Neut | Hamster IgG |
| NEUT-1294CQ | Rat Anti-Il1r1 Recombinant Antibody (clone CBL936) | ELISA, IP, Neut, WB | Rat IgG1 |
| NEUT-1295CQ | Rat Anti-Il1r1 Recombinant Antibody (clone CBL937) | Neut, WB | Rat IgG1 |
| CAT | Product Name | Application | Type |
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| MOR-1799 | Rabbit Anti-IL1R1 Recombinant Antibody (clone DS1799AB) | WB, FC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1862-FY-F(E) | Human Anti-IL1R1 Recombinant Antibody (clone 26F5); scFv Fragment | ELISA | Human scFv |
| HPAB-1863-FY-F(E) | Human Anti-IL1R1 Recombinant Antibody (clone 15C4); scFv Fragment | ELISA | Human scFv |
| HPAB-1864-FY-F(E) | Human Anti-IL1R1 Recombinant Antibody (clone 27F2); scFv Fragment | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1862-FY-S(P) | Human Anti-IL1R1 Recombinant Antibody (clone 26F5); Fab Fragment | ELISA | Human Fab |
| HPAB-1863-FY-S(P) | Human Anti-IL1R1 Recombinant Antibody (clone 15C4); Fab Fragment | ELISA | Human Fab |
| HPAB-1864-FY-S(P) | Human Anti-IL1R1 Recombinant Antibody (clone 27F2); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC207 | Recombinant Anti-IL1R1 Vesicular Antibody, EV Displayed (VS-0425-YC207) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
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