Human Anti-IL1R1 (clone 26F5) scFv-Fc Chimera (CAT#: VS-0125-FY73)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Species Reactivity
• Human

• Clone
• 26F5

• Applications
• Inhibition

• Related Disease
• Inflammation and joint injury

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• No preservatives

• Stabilizer
• No Stabilizers

• Sterility
• 0.2 μM filtered

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The anti-scFv-Fc antibody can inhibit IL-1-induced NF-κB nuclear translocation by competitively binding to IL-1R1, potentially reducing inflammation and joint damage caused by IL-1. These antibodies have been shown in bioassays to significantly suppress IL-1-mediated signaling.

• Alternative Names
• Interleukin 1 Receptor Type 1

• Gene ID
• 3554

• UniProt ID
• P14778

• Sequence Similarities
• Belongs to the interleukin-1 receptor family.

• Cellular Localization
• Membrane; Single-pass type I membrane protein
  Cell membrane
  Secreted

• Post Translation Modifications
• A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).
  Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.
  Glycosylation at Asn100, Asn193, Asn233, Asn249, Asn263, and Asn297
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 6 sites, 1 N-linked glycan (1 site)

• Protein Refseq
• XP_005263987.1; XP_005263991.1; XP_011509417.1; XP_011509418.1; XP_011509420.1

• Function
• After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways.
  Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits.
  Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.
  Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells.

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

• HPAB-1862-FY
• Human Anti-IL1R1 Recombinant Antibody (clone 26F5)

• HPAB-1862-FY-F(E)
• Human Anti-IL1R1 Recombinant Antibody (clone 26F5); scFv Fragment

• HPAB-1862-FY-S(P)
• Human Anti-IL1R1 Recombinant Antibody (clone 26F5); Fab Fragment

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