Human Anti-IL20 (clone 6E11) scFv-Fc Chimera
CAT#: VS-0425-FY126
The anti-IL20 scFv-FC is an engineered single-chain variable fragment fused to the Fc domain, which targets interleukin-20 (IL-20), a cytokine implicated in psoriasis and other inflammatory disorders, aiming to inhibit its interactions with receptors and mitigate associated pathological processes.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human stomach
Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in parietal cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25802/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25802/57430_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25802/57430_A_9_3.jpg
Normal Tissue
Figure 4 Liver
Cholangiocytes Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25802/57430_A_7_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25802/57430_A_7_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (SiHa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000162891-IL20
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL20
- Species Reactivity
- Human, Mouse
- Clone
- Clone 6E11
- Applications
- Neutralization, ELISA
- Related Disease
- Inflammatory bowel disease (IBD); Crohn's disease; psoriasis; vascular inflammation and atherosclerosis; atopic dermatitis and cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 20
- Gene ID
- 50604
- UniProt ID
- Q9NYY1
- Long Name
- Interleukin 20
- Sequence Similarities
- Belongs to the IL-10 family.
- Cellular Localization
- Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation (PubMed:17277128, 34403503).; Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity (PubMed:17277128).; Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration (PubMed:28424238).
- Post Translation Modifications
- Modification sites at PhosphoSitePlus
Modification sites at neXtProt
Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001372094.1; NP_001372095.1; NP_001372096.1; NP_061194.2
- Function
- Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation.
Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity.
Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "IL20"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0009CL | Human Anti-IL20 Recombinant Antibody (TAB-0009CL) | Inhib, IB, FC, RIA | Humanized Antibody |
| TAB-0009CL-S(P) | Human Anti-IL20 Recombinant Antibody; scFv Fragment (TAB-0009CL-S(P)) | Inhib, ELISA, SPR | Humanized scFv |
| TAB-0009CL-F(E) | Human Anti-IL20 Recombinant Antibody; Fab Fragment (TAB-0009CL-F(E)) | Inhib, ELISA, SPR | Humanized Fab |
| TAB-565LC | Anti-human IL20 Recombinant Antibody (TAB-565LC) | ELISA, Inhib, FuncS | Humanized antibody |
| TAB-565LC-F(E) | Anti-human IL20 Fab Fragment (TAB-565LC-F(E)) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-560LC | Rat Anti-IL20 Recombinant Antibody (TAB-560LC) | ELISA | Rat IgG |
| TAB-560LC-S(P) | Rat Anti-IL20 Recombinant Antibody; scFv Fragment (TAB-560LC-S(P)) | ELISA | Rat scFv |
| TAB-560LC-F(E) | Rat Anti-IL20 Recombinant Antibody; Fab Fragment (TAB-560LC-F(E)) | ELISA | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-561LC | Anti-human IL20 Recombinant Antibody (20A10) (TAB-561LC) | ELISA, Neut, SPR | Human antibody |
| TAB-562LC | Anti-human IL20 Recombinant Antibody (2A11) (TAB-562LC) | ELISA, Neut, SPR | Human antibody |
| TAB-563LC | Anti-human IL20 Recombinant Antibody (7D1) (TAB-563LC) | ELISA, Neut, SPR | Human antibody |
| TAB-564LC | Anti-human IL20 Recombinant Antibody (6E11) (TAB-564LC) | ELISA, Neut | Human antibody |
| TAB-561LC-F(E) | Anti-human IL20 Fab Fragment (20A10) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0963CT | Recombinant Mouse anti-Human IL20 Monoclonal antibody (EML1475) | WB | |
| HPAB-0008-LS | Human Anti-IL20 Recombinant Antibody (HPAB-0008-LS) | Inhib | Humanized IgG |
| HPAB-0009-LS | Human Anti-IL20 Recombinant Antibody (HPAB-0009-LS) | Inhib | Humanized IgG |
| HPAB-0723-CN | Human Anti-IL20 Recombinant Antibody (clone 15D2) | WB, ELISA, FC, IHC | Human IgG4, κ |
| HPAB-0724-CN | Human Anti-IL20 Recombinant Antibody (clone 5B7) | WB, FC, IHC | Human IgG4, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1324CQ | Rat Anti-Il20 Recombinant Antibody (clone CBL626) | Neut | Rat IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4256 | Rabbit Anti-IL20 Recombinant Antibody (clone SI336DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0008-LS-F(E) | Human Anti-IL20 Recombinant Antibody; Fab Fragment (HPAB-0008-LS-F(E)) | Inhib | Humanized Fab |
| HPAB-0009-LS-F(E) | Human Anti-IL20 Recombinant Antibody; Fab Fragment (HPAB-0009-LS-F(E)) | Inhib | Humanized Fab |
| HPAB-0723-CN-F(E) | Human Anti-IL20 Recombinant Antibody (clone 15D2); Fab Fragment | WB, ELISA, Neut | Human Fab |
| HPAB-0724-CN-F(E) | Human Anti-IL20 Recombinant Antibody (clone 5B7); Fab Fragment | WB, ELISA, Neut | Human Fab |
| HPAB-0069-WJ-F(E) | Human Anti-IL20 Recombinant Antibody; Fab Fragment (HPAB-0069-WJ-F(E)) | IHC, ELISA, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0008-LS-S(P) | Human Anti-IL20 Recombinant Antibody; scFv Fragment (HPAB-0008-LS-S(P)) | Inhib | Humanized scFv |
| HPAB-0009-LS-S(P) | Human Anti-IL20 Recombinant Antibody; scFv Fragment (HPAB-0009-LS-S(P)) | Inhib | Humanized scFv |
| HPAB-0723-CN-S(P) | Human Anti-IL20 Recombinant Antibody (clone 15D2); scFv Fragment | WB, ELISA, Neut | Human scFv |
| HPAB-0724-CN-S(P) | Human Anti-IL20 Recombinant Antibody (clone 5B7); scFv Fragment | WB, ELISA, Neut | Human scFv |
| HPAB-0069-WJ-S(P) | Human Anti-IL20 Recombinant Antibody; scFv Fragment (HPAB-0069-WJ-S(P)) | IHC, ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-H34 | Afuco™ Anti-IL20 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H34) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC861 | AbPlus™ Anti-Il20 Magnetic Beads (VS-0724-YC861) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC176 | Recombinant Anti-IL20 Eliminating Antibody, pH-Sensitive (VS-0625-YC176) | Antigen-Sweeping In Vivo. | Human IgG4 kappa |
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