Human Anti-IL22 scFv-Fc Chimera (VS-0425-FY127) (CAT#: VS-0425-FY127)
The anti-IL22 scFv-FC is a recombinant antibody fragment that specifically recognizes and binds to interleukin-22 (IL-22), a cytokine linked to inflammatory conditions, with the goal of blocking its signaling pathways to reduce inflammation and tissue damage.
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RNA Expression
Figure 1 RNA cell line category: Not detected
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000127318-IL22
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000127318-IL22
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL22
- Species Reactivity
- Cynomolgus monkey, Human, Rat
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Scleritis and Acute Generalized Exanthematous Pustulosis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 22
- Gene ID
- 50616
- UniProt ID
- Q9GZX6
- Long Name
- Interleukin 22
- Sequence Similarities
- Belongs to the IL-10 family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn54, Asn68, and Asn97
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 3 sites
- Protein Refseq
- NP_065386.1
- Function
- Cytokine that plays a critical role in modulating tissue responses during inflammation.
Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage.
Unlike most of the cytokines, has no effect on immune cells.
Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB.
Related Resources
Inflammatory Bowel Diseases
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "IL22"
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Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1442-sdAb | Recombinant Anti-Human IL22 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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