Human Anti-IL36R scFv-Fc Chimera (VS-0425-FY130) (CAT#: VS-0425-FY130)
The anti-IL36R scFv-FC is a specific antibody fragment that targets the interleukin-36 receptor (IL-36R), which is involved in the pathogenesis of various inflammatory skin and joint diseases, with the intention of blocking IL-36 cytokines and reducing inflammation.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Specifications
- Immunogen
- Full-length IL36R (IL-1R12)
- Host Species
- Human
- Type
- Human IgG4, scFv-Fc
- Specificity
- Human IL36R
- Species Reactivity
- Human
- Applications
- Inhibition
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- IL1RL2; IL-1Rrp2; IL36R
- Long Name
- IL-36R (Interleukin-36 Receptor
- Function
- The IL36R gene encodes the interleukin-36 receptor, a member of the interleukin-1 receptor family. This receptor binds to several IL-36 cytokines, including IL-36α, IL-36β, and IL-36γ, which are primarily produced by epithelial cells and immune cells in response to inflammatory stimuli or tissue damage.
Activation of IL-36R by its ligands triggers intracellular signaling pathways, mainly involving NF-κB and MAPK, leading to the production of pro-inflammatory cytokines, chemokines, and antimicrobial peptides. This signaling cascade plays a significant role in regulating local inflammatory responses, particularly in barrier tissues like the skin and mucosa. The IL-36R pathway is implicated in the pathogenesis of various inflammatory skin diseases and autoimmune conditions, highlighting its importance in immune homeostasis and disease.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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