Human Anti-IL36R scFv-Fc Chimera (VS-0425-FY130)
CAT#: VS-0425-FY130
The anti-IL36R scFv-FC is a specific antibody fragment that targets the interleukin-36 receptor (IL-36R), which is involved in the pathogenesis of various inflammatory skin and joint diseases, with the intention of blocking IL-36 cytokines and reducing inflammation.
Specifications
- Immunogen
- Full-length IL36R (IL-1R12)
- Host Species
- Human
- Type
- Human IgG4, scFv-Fc
- Specificity
- Human IL36R
- Species Reactivity
- Human
- Applications
- Inhibition
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- IL1RL2; IL-1Rrp2; IL36R
- Long Name
- IL-36R (Interleukin-36 Receptor
- Function
- The IL36R gene encodes the interleukin-36 receptor, a member of the interleukin-1 receptor family. This receptor binds to several IL-36 cytokines, including IL-36α, IL-36β, and IL-36γ, which are primarily produced by epithelial cells and immune cells in response to inflammatory stimuli or tissue damage.
Activation of IL-36R by its ligands triggers intracellular signaling pathways, mainly involving NF-κB and MAPK, leading to the production of pro-inflammatory cytokines, chemokines, and antimicrobial peptides. This signaling cascade plays a significant role in regulating local inflammatory responses, particularly in barrier tissues like the skin and mucosa. The IL-36R pathway is implicated in the pathogenesis of various inflammatory skin diseases and autoimmune conditions, highlighting its importance in immune homeostasis and disease.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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