Human Anti-IL4R (clone 12B5) scFv-Fc Chimera (CAT#: VS-0425-FY132)
The anti-IL4R scFv-FC is a recombinant protein that targets the interleukin-4 receptor (IL4R), which plays a crucial role in mediating immune responses and inflammation. By binding to IL4R, this engineered single-chain variable fragment (scFv) fused with the Fc region of IgG can inhibit IL-4 signaling pathways, potentially providing therapeutic benefits in diseases such as asthma, allergic responses, and other IL-4 related conditions.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to nucleoplasm, plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70380/1812_F10_5_cr59ef13a97c5ff_selected.jpg
(Immunofluorescent staining of human cell line HEL shows localization to nucleoplasm, plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/70380/1812_F10_5_cr59ef13a97c5ff_selected.jpg
Figure 2 Tonsil
(High expression in tonsil)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50124/ihc_selected.jpg
(High expression in tonsil)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50124/ihc_selected.jpg
Figure 3 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows distinct cytoplasmic positivity in subsets of cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4451/ihc_selected.jpg
(Immunohistochemical staining of human tonsil shows distinct cytoplasmic positivity in subsets of cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4451/ihc_selected.jpg
Figure 4 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50124/123264_A_9_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50124/123264_A_9_3.jpg
Figure 5 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50124/123264_A_8_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/50124/123264_A_8_5.jpg
Figure 6 RNA cell line category: Cell line enhanced (Daudi, HBEC3-KT, HDLM-2, U-698)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077238-IL4R
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077238-IL4R
Specifications
- Immunogen
- A soluble human IL-4 receptor polypeptide.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL4R
- Species Reactivity
- Human
- Clone
- 12B5
- Applications
- Blocking
- Related Disease
- Ige Responsiveness, Atopic and Human Immunodeficiency Virus Type 1
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 4 Receptor
- Gene ID
- 3566
- UniProt ID
- P24394
- Long Name
- Interleukin 4 Receptor
- Sequence Similarities
- Belongs to the type I cytokine receptor family. Type 4 subfamily.
- Cellular Localization
- Secreted
- Post Translation Modifications
- On IL4 binding, phosphorylated on C-terminal tyrosine residues.
Phosphorylation on any one of tyrosine residues, Tyr-575, Tyr-603 or Tyr-631, is required for STAT6-induced gene induction.
The soluble form (sIL4R/IL4BP) can also be produced by proteolytic cleavage at the cell surface (shedding) by a metalloproteinase.
Glycosylation at Asn53, Asn98, Asn128, Asn134, Asn176, and Asn209
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect IL4RA_HUMAN (2053)
Glycosylation from GlyGen 6 sites, 4 N-linked glycans (2 sites)
- Protein Refseq
- XP_005255365.1; XP_011544127.1; XP_011544128.1; XP_011544129.1; XP_011544130.1
- Function
- Receptor for both interleukin 4 and interleukin 13.
Couples to the JAK1/2/3-STAT6 pathway.
The IL4 response is involved in promoting Th2 differentiation.
The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation.
In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. IL4RA_HUMAN,P24394
Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1757z | Mouse Anti-IL4R Recombinant Antibody (clone 28H12) | WB, ELISA, FC, IHC, FuncS | Mouse IgG1 |
| HPAB-0291-YC | Human Anti-IL4R Recombinant Antibody (clone Antibody 1) | HTRF, FuncS | Human IgG |
| HPAB-1447LY | Mouse Anti-IL4R Recombinant Antibody (HPAB-1447LY) | FC, ELISA, Block | Mouse IgG |
| HPAB-1448LY | Mouse Anti-IL4R Recombinant Antibody (HPAB-1448LY) | FC, ELISA, Block | Mouse IgG |
| HPAB-1449LY | Mouse Anti-IL4R Recombinant Antibody (HPAB-1449LY) | FC, ELISA, Block | Mouse IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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