Recombinant Human Anti-INS Soluble TCR (3F2) (KIH)

Name: Recombinant Human Anti-INS Soluble TCR (3F2) (KIH)
SKU: VS-0622-YF5774
Rating: 5 (1 reviews)

CAT#: VS-0622-YF5774

Human TCR (3F2) recognizes INS peptide (ALWGPDPAAA) in the context of HLA-A2. Soluble TCR is expressed with Knob-in-hole (KIH) strategy (scTCR-hIgG Knob, scTCR-hIgG Hole). Please note that the activity is not guaranteed.

Gene Expression

Normal Tissue Figure 1 Pancreas

Pancreatic endocrine cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4932/115849_A_1_3.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (EFO-21, U-2 OS, U-698)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000254647-INS

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Specifications

Host Species
Human

Target
INS

Species Reactivity
Human

Epitope
ALWGPDPAAA

MHC
HLA-A2

Clone
3F2

Type
Soluble TCR (KIH)

Related Disease
Type 1 diabetes

TCR Expression Strategy
KIH strategy: scTCR-human IgG Knob and scTCR-human IgG Hole can form heterodimer based on Knob-in-hole (KIH) strategy. The soluble TCR contains single chain TCR. With this KIH antibody production strategy, VL/VH will be replaced with Valpha-linker-Vbeta (single chain TCR).

Target

Alternative Names
Preproinsulin; PPI; INS; Insulin precursor; IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10

Gene ID
3630

UniProt ID
P01308

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Related Diseases

Maturity Onset Diabetes of the Young

Downloadable Resources

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Datasheet

Datasheet - VS-0622-YF5774.pdf

MSDS

MSDS - VS-0622-YF5774.pdf

COA

Certificate of Analysis Lookup

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