Human Anti-ITGA2 (clone Vatelizumab) scFv-Fc Chimera
CAT#: VS-0425-FY137
This product is a recombinant scFv that targets integrin alpha-2 (ITGA2), which plays a significant role in mediating cell adhesion to collagen and other extracellular matrix components. The scFv-FC design allows for improved binding affinity, stability, and enhanced effector functions due to the Fc region. This makes anti-ITGA2 scFv-FC useful for research areas like hematology, cancer biology, and regenerative medicine.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/60991/1358_H10_6_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line HaCaT
Immunofluorescent staining of human cell line HaCaT shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/60991/1591_A6_2_red_green.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63556/141951_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63556/141951_A_9_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63556/141951_A_7_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Collecting ducts
Staining: High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63556/141951_A_9_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63556/141951_A_6_6.jpg
Normal Tissue
Figure 8 Endometrium
Glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/63556/141951_B_6_3.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (BJ hTERT+, HaCaT, hTERT-RPE1, HUVEC TERT2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164171-ITGA2
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Specifications
- Immunogen
- The immunogen is human fibrosarcoma HT1080 cells.
- Host Species
- Human
- Type
- Human IgG4, scFv-Fc
- Specificity
- Human ITGA2
- Species Reactivity
- Human
- Clone
- Vatelizumab
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Bleeding Disorder, Platelet-Type, 9 and Fetal And Neonatal Alloimmune Thrombocytopenia
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Integrin Subunit Alpha 2
- Gene ID
- 3673
- UniProt ID
- P17301
- Long Name
- Integrin Subunit Alpha 2
- Sequence Similarities
- Belongs to the integrin alpha chain family.
- Cellular Localization
- Membrane
- Post Translation Modifications
- Glycosylation at Asn105, Asn112, Asn343, Asn432, Asn460, Asn475, Asn699, Asn1057, Asn1074, and Asn1081
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect ITA2_HUMAN (1406)
Glycosylation from GlyGen 11 sites, 75 N-linked glycans (9 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_002194.2
- Function
- Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin.
It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. ITA2_HUMAN,P17301
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A. ITA2_HUMAN,P17301
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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