Human Anti-ITGB7 scFv-Fc Chimera (VS-0425-FY135)
CAT#: VS-0425-FY135
The anti-ITGB7 scFv-FC is designed to specifically bind to integrin beta-7 (ITGB7), a protein involved in lymphocyte trafficking to sites of inflammation. This therapeutic fusion protein can inhibit the binding of ITGB7 to its ligands, thereby disrupting inflammatory processes and providing a potential new approach for treating autoimmune diseases, such as inflammatory bowel disease and multiple sclerosis.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42277/476_E12_1_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (Karpas-707, RPMI-8226)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000139626-ITGB7
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human ITGB7
- Species Reactivity
- Human
- Applications
- ELISA
- Related Disease
- Inflammatory bowel disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Integrin Subunit Beta 7
- Gene ID
- 3695
- UniProt ID
- P26010
- Long Name
- Integrin Subunit Beta 7
- Sequence Similarities
- Belongs to the integrin beta chain family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn68, Asn279, Asn434, Asn477, Asn665, Asn674, Asn531, and Asn590
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 8 sites, 7 N-linked glycans (1 site)
- Protein Refseq
- NP_000880.1; NP_001401085.1; NP_001401086.1; NP_001401087.1; NP_001401088.1
- Function
- Integrin ITGA4/ITGB7 (alpha-4/beta-7) (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT) (Probable).
Integrin ITGA4/ITGB7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract.
Interacts also with VCAM1 and fibronectin, an extracellular matrix component (Probable).
It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin (Probable).
Interactions involve the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin (Probable).
Integrin ITGAE/ITGB7 (alpha-E/beta-7, HML-1) is a receptor for E-cadherin.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1593z | Mouse Anti-ITGB7 Recombinant Antibody (MOB-1593z) | IP, Block, FC | Mouse IgG2a |
| VS3-FY780 | Recombinant Mouse Anti-ITGB7 Antibody (clone 4C6B4H9) | ELISA, IHC, FC | Mouse IgG1 |
| VS7-0425-WR163 | Mouse Anti-ITGB7 Recombinant Antibody (clone 6A2G4) | IHC, ICC, FC | Mouse IgG1 |
| VS7-0425-WR164 | Mouse Anti-ITGB7 Recombinant Antibody (clone 4C5D2) | IHC, ICC, FC | Mouse IgG1 |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1593z-F(E) | Recombinant Anti-Human ITGB7 Antibody Fab Fragment | IF, FC, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1593z-S(P) | Recombinant Anti-Human ITGB7 Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0578CL | Human Anti-ITGB7 Recombinant Antibody (TAB-0578CL) | ELISA | Humanized antibody |
| TAB-0578CL-S(P) | Human Anti-ITGB7 Recombinant Antibody; scFv Fragment (TAB-0578CL-S(P)) | ELISA | Humanized scFv |
| TAB-0578CL-F(E) | Human Anti-ITGB7 Recombinant Antibody; Fab Fragment (TAB-0578CL-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0302MZ | Chicken Anti-ITGB7 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1604CQ | Recombinant Rat Anti-Itgb7 Antibody (FIB27) | FC, IP, BL | IgG2a, κ |
| NEUT-1605CQ | Recombinant Rat Anti-Itgb7 Antibody (FIB504) | FC, BL | IgG2a, κ |
| NEUT-1606CQ | Recombinant Rat Anti-Itgb7 Antibody (MAB0841) | BL, FC, IHC-Fr, IP | IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1888 | Hi-Affi™ Recombinant Rabbit Anti-ITGB7 Monoclonal Antibody (DS1888AB) | ICC, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC329 | Recombinant Anti-ITGB7 Vesicular Antibody, EV Displayed (VS-0425-YC329) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3668 | Anti-Mouse ITGB7 Immunohistochemistry Kit | IHC |
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