Human Anti-KLKB1 scFv-Fc Chimera (VS-0425-FY139)
CAT#: VS-0425-FY139
This scFv-FC targets the KLKB1 gene product, which encodes for the enzyme kallikrein-1 involved in blood coagulation and inflammation. The anti-KLKB1 scFv-FC can be utilized in diagnostics and research focusing on coagulation pathways, cardiovascular diseases, and inflammatory responses. The Fc fusion increases half-life and allows for various applications, including potential therapeutic avenues in blood-related disorders.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (NTERA-2, SCLC-21H, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164344-KLKB1
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human KLKB1
- Species Reactivity
- Human
- Applications
- ELISA
- Related Disease
- Prekallikrein Deficiency; Congenital Prekallikrein Deficiency
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Kallikrein B1; Kallikrein B, Plasma (Fletcher Factor) 1; Plasma Prekallikrein; Fletcher Factor; Kininogenin; KLK3; PKK
- Gene ID
- 3818
- UniProt ID
- P03952
- Long Name
- Kallikrein B1
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn127, Asn164, Asn254, Asn308, Asn316, Asn396, Asn453, and Asn494
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect KLKB1_HUMAN (714)
Glycosylation from GlyGen 9 sites, 23 N-linked glycans (8 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_016863670.1
- Function
- The enzyme cleaves Lys-Arg and Arg-Ser bonds.
It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface.
It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "KLKB1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1983z | Mouse Anti-KLKB1 Recombinant Antibody (clone 32C8) | WB | Mouse IgG1 |
| PABL-257 | Human Anti-KLKB1 Recombinant Antibody (PABL-257) | Block, FuncS | Human IgG |
| MOB-1612CT | Recombinant Mouse anti-Human KLKB1 Monoclonal antibody (24H22) | ELISA, IHC-P, Inhib, WB | |
| HPAB-1573-FY | Human Anti-KLKB1 Recombinant Antibody (HPAB-1573-FY) | Inhib | Human IgG |
| VS-0724-XY81 | Human Anti-KLKB1 Recombinant Antibody (clone STAR-0215) | ELISA, SPR, Neut | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-472CL | Human Anti-KLKB1 Recombinant Antibody (TAB-472CL) | Inhib, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-257 | Human Anti-KLKB1 Recombinant Antibody; scFv Fragment (PSBL-257) | Block, FuncS | Human scFv |
| HPAB-1573-FY-F(E) | Human Anti-KLKB1 Recombinant Antibody; Fab Fragment (HPAB-1573-FY-F(E)) | Inhib | Human Fab |
| HPAB-1574-FY-F(E) | Human Anti-KLKB1 Recombinant Antibody; Fab Fragment (HPAB-1574-FY-F(E)) | ELISA | Human Fab |
| HPAB-1575-FY-F(E) | Human Anti-KLKB1 Recombinant Antibody; Fab Fragment (HPAB-1575-FY-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-257 | Human Anti-KLKB1 Recombinant Antibody; Fab Fragment (PFBL-257) | Block, FuncS | Human Fab |
| HPAB-1573-FY-S(P) | Human Anti-KLKB1 Recombinant Antibody; scFv Fragment (HPAB-1573-FY-S(P)) | Inhib | Human scFv |
| HPAB-1574-FY-S(P) | Human Anti-KLKB1 Recombinant Antibody; scFv Fragment (HPAB-1574-FY-S(P)) | ELISA | Human scFv |
| HPAB-1575-FY-S(P) | Human Anti-KLKB1 Recombinant Antibody; scFv Fragment (HPAB-1575-FY-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1655CQ | Recombinant Mouse Anti-KLKB1 Antibody (13G11) | ELISA, Inhib, WB | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1965 | Hi-Affi™ Recombinant Rabbit Anti-KLKB1 Monoclonal Antibody (DS1965AB) | WB, IHC, IP | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3811 | Anti-KLKB1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY3812 | Anti-Rat KLKB1 Immunohistochemistry Kit | IHC |
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