Human Anti-KLKB1 scFv-Fc Chimera (VS-0425-FY139) (CAT#: VS-0425-FY139)
This scFv-FC targets the KLKB1 gene product, which encodes for the enzyme kallikrein-1 involved in blood coagulation and inflammation. The anti-KLKB1 scFv-FC can be utilized in diagnostics and research focusing on coagulation pathways, cardiovascular diseases, and inflammatory responses. The Fc fusion increases half-life and allows for various applications, including potential therapeutic avenues in blood-related disorders.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (NTERA-2, SCLC-21H, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164344-KLKB1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000164344-KLKB1
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human KLKB1
- Species Reactivity
- Human
- Applications
- ELISA
- Related Disease
- Prekallikrein Deficiency; Congenital Prekallikrein Deficiency
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Kallikrein B1; Kallikrein B, Plasma (Fletcher Factor) 1; Plasma Prekallikrein; Fletcher Factor; Kininogenin; KLK3; PKK
- Gene ID
- 3818
- UniProt ID
- P03952
- Long Name
- Kallikrein B1
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn127, Asn164, Asn254, Asn308, Asn316, Asn396, Asn453, and Asn494
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect KLKB1_HUMAN (714)
Glycosylation from GlyGen 9 sites, 23 N-linked glycans (8 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_016863670.1
- Function
- The enzyme cleaves Lys-Arg and Arg-Ser bonds.
It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface.
It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "KLKB1"
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IgG Antibody Products
Human Antibody Products
ScFv Antibody Products
Fab Antibody Products
Blocking Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1983z | Mouse Anti-KLKB1 Recombinant Antibody (clone 32C8) | WB | Mouse IgG1 |
| MOB-1612CT | Recombinant Mouse anti-Human KLKB1 Monoclonal antibody (24H22) | ELISA, IHC-P, Inhib, WB | |
| HPAB-1573-FY | Human Anti-KLKB1 Recombinant Antibody (HPAB-1573-FY) | Inhib | Human IgG |
| HPAB-1574-FY | Human Anti-KLKB1 Recombinant Antibody (HPAB-1574-FY) | ELISA | Human IgG |
| VS-0724-XY81 | Human Anti-KLKB1 Recombinant Antibody (clone STAR-0215) | ELISA, SPR, Neut | Human IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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