Human Anti-KLRC1 scFv-Fc Chimera (VS-0425-FY157)
CAT#: VS-0425-FY157
This antibody targets KLRC1 (Killer Cell Lectin-like Receptor C1), also known as NKG2A. KLRC1 is a receptor expressed on natural killer (NK) cells and some T cells, involved in the recognition of MHC class I HLA-E molecules and can inhibit NK cell cytotoxicity. This scFv-FC format allows for targeted binding to KLRC1, potentially modulating NK cell activity or for detection purposes.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/58052/1522_A10_3_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (HeLa, Karpas-707)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000134545-KLRC1
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Specifications
- Immunogen
- Human KLRC1/NKG2A/CD159a/CD94 as an immunogen.
- Host Species
- Human
- Type
- Human IgG4, scFv-Fc
- Specificity
- Human KLRC1
- Species Reactivity
- Human
- Applications
- ELISA, Immunohistochemistry, Flow Cytometry, Immunoprecipitation, Immunofluorescence
- Related Disease
- Autoimmune or inflammatory disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Killer Cell Lectin Like Receptor C1; Killer Cell Lectin-Like Receptor Subfamily C, Member 1; CD159 Antigen-Like Family Member A; NKG2-1/B Activating NK Receptor; NKG2-A/B-Activating NK Receptor; NK Cell Receptor A; NKG2A; NKG2-A/NKG2-B Type II Integral Membrane Protein
- Gene ID
- 3821
- UniProt ID
- P26715
- Long Name
- Killer Cell Lectin Like Receptor C1
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Phosphorylated.
Glycosylation at Asn102, Asn103, Asn151, and Asn180
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 5 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001291377.1; NP_002250.2; NP_015567.2; NP_998822.2; NP_998823.2
- Function
- Immune inhibitory receptor involved in self-nonself discrimination.
In complex with KLRD1 on cytotoxic and regulatory lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib molecule HLA-E loaded with self-peptides derived from the signal sequence of classical MHC class Ia molecules.
Enables cytotoxic cells to monitor the expression of MHC class I molecules in healthy cells and to tolerate self.
Upon HLA-E-peptide binding, transmits intracellular signals through two immunoreceptor tyrosine-based inhibition motifs (ITIMs) by recruiting INPP5D/SHP-1 and INPPL1/SHP-2 tyrosine phosphatases to ITIMs, and ultimately opposing signals transmitted by activating receptors through dephosphorylation of proximal signaling molecules.
Key inhibitory receptor on natural killer (NK) cells that regulates their activation and effector functions.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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| MOB-604 | Recombinant Anti-human KLRC1 Antibody | WB, Neut, FuncS | IgG |
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| CAT | Product Name | Application | Type |
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| MOB-604-F(E) | Recombinant Anti-human KLRC1 Antibody Fab Fragment | RIA, ELISA, FuncS | Fab |
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| CAT | Product Name | Application | Type |
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| MOB-604-S(P) | Recombinant Anti-human KLRC1 Antibody scFv Fragment | ELISA, IF, FuncS | scFv |
| MHH-604-S(P) | Recombinant Human Anti-human KLRC1 Antibody scFv Fragment | WB, Neut, FuncS | scFv |
| CAT | Product Name | Application | Type |
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| TAB-0338CL | Human Anti-KLRC1 Recombinant Antibody (TAB-0338CL) | IHC | Humanized antibody |
| TAB-0338CL-S(P) | Human Anti-KLRC1 Recombinant Antibody; scFv Fragment (TAB-0338CL-S(P)) | ELISA | Humanized scFv |
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| TAB-437CQ | Anti-Human KLRC1 Recombinant Antibody (TAB-437CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG4, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-437CQ | Afuco™ Anti-KLRC1 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-437CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
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