Human Anti-LRP6 scFv-Fc Chimera (VS-0325-FY82)
CAT#: VS-0325-FY82
The anti-LRP6 scFv-Fc antibody targets LRP6, a co-receptor involved in Wnt signaling pathways, which are critical for cell proliferation and differentiation. It can modulate Wnt signaling, making it a potential tool for studying developmental biology and cancer. The scFv-Fc format enhances its stability and bioavailability, allowing for prolonged action in vivo.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IHC staining of human colon
Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human kidney
High expression. RNA expression: 4.4 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29925/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human lymph node
Low expression. RNA expression: 0.8 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29925/62204_A_7_8_val_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12171_B_8_5.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12026_A_8_4.jpg
Normal Tissue
Figure 6 Testis
Spermatogonia cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4490/12026_A_4_6.jpg
RNA Expression
Figure 7 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000070018-LRP6
❮
❯
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human LRP6
- Species Reactivity
- Human
- Applications
- ELISA
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- LRP-6
- Gene ID
- 4040
- UniProt ID
- O75581
- Long Name
- Low-density lipoprotein receptor-related protein 6
- Sequence Similarities
- Belongs to the LDLR family.
- Cellular Localization
- Cell membrane; Endoplasmic reticulum; Membrane raft
- Post Translation Modifications
- Dual phosphorylation of cytoplasmic PPPSP motifs sequentially by GSK3 and CK1 is required for AXIN1-binding, and subsequent stabilization and activation of beta-catenin via preventing GSK3-mediated phosphorylation of beta-catenin.
Phosphorylated, in vitro, by GRK5/6 within and outside the PPPSP motifs.
Phosphorylation at Ser-1490 by CDK14 during G2/M phase leads to regulation of the Wnt signaling pathway during the cell cycle.
Phosphorylation by GSK3B is induced by RPSO1 binding and inhibited by DKK1.
Phosphorylated, in vitro, by casein kinase I on Thr-1479.
Undergoes gamma-secretase-dependent regulated intramembrane proteolysis (RIP).
The extracellular domain is first released by shedding, and then, through the action of gamma-secretase, the intracellular domain (ICD) is released into the cytoplasm where it is free to bind to GSK3B and to activate canonical Wnt signaling.
Palmitoylation on the two sites near the transmembrane domain leads to release of LRP6 from the endoplasmic reticulum.
Mono-ubiquitinated which retains LRP6 in the endoplasmic reticulum.
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
N-glycosylation is required for cell surface location.
Glycosylation at Asn42, Asn81, Asn281, Asn433, Asn486, Asn692, Asn859, Asn865, Asn926, and Asn1039
Ubiquitination at Lys1403
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 12 sites
- Protein Refseq
- XP_047284800.1; XP_054187674.1; XP_054228026.1; NP_001401173.1; NP_001401174.1
- Function
- Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation.
The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0325-FY82. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Signaling Pathways
Canonical Wnt Signaling Pathway
JAK-STAT Signaling Pathway
Non-Canonical Wnt Signaling Pathway
Related Diseases
Hepatocellular Carcinoma
Pancreatic Cancer
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "LRP6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0115CL | Chimeric Anti-Human LRP6 Recombinant Antibody | ELISA, FC, Inhib, FuncS, Internalization | Chimeric (mouse/human) |
| TAB-0115CL-S(P) | Anti-Human LRP6 Recombinant Antibody scFv Fragment | ELISA, FC, Inhib, FuncS, Internalization | Chimeric (mouse/human) |
| TAB-0115CL-F(E) | Anti-Human LRP6 Recombinant Antibody Fab Fragment | ELISA, FC, Inhib, FuncS, Internalization | Chimeric (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0705CL | Human Anti-LRP6 Recombinant Antibody (TAB-0705CL) | ELISA, FC, Inhib | Human antibody |
| TAB-0705CL-F(E) | Human Anti-LRP6 Recombinant Antibody Fab Fragment (TAB-0705CL-F(E)) | ELISA, FC | Human antibody |
| TAB-0706CL-F(E) | Human Anti-LRP6 Recombinant Antibody Fab Fragment (TAB-0706CL-F(E)) | ELISA, FC | Human antibody |
| TAB-0707CL-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (TAB-0707CL-F(E)) | ELISA | Human Fab |
| TAB-0708CL-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (TAB-0708CL-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0092CL-S(P) | Mouse Anti-LRP6 Recombinant Antibody scFv Fragment (TAB-0092CL-S(P)) | ELISA, FC, Inhib, FuncS, Internalization | |
| TAB-0093CL-S(P) | Mouse Anti-LRP6 Recombinant Antibody scFv Fragment (TAB-0093CL-S(P)) | ELISA, FC, Inhib, FuncS, Internalization | |
| TAB-0094CL-S(P) | Mouse Anti-LRP6 Recombinant Antibody scFv Fragment (TAB-0094CL-S(P)) | ELISA, FC, Inhib, FuncS, Internalization | |
| TAB-0703CL-F(E) | Mouse Anti-LRP6 Recombinant Antibody; Fab Fragment (TAB-0703CL-F(E)) | ELISA, IHC | Mouse Fab |
| TAB-0704CL-F(E) | Mouse Anti-LRP6 Recombinant Antibody; Fab Fragment (TAB-0704CL-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0349CL-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (TAB-0349CL-F(E)) | ELISA | Humanized Fab |
| TAB-0350CL-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (TAB-0350CL-F(E)) | ELISA | Humanized Fab |
| TAB-0351CL-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (TAB-0351CL-F(E)) | ELISA | Humanized Fab |
| TAB-0352CL-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (TAB-0352CL-F(E)) | ELISA | Humanized Fab |
| TAB-0353CL-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (TAB-0353CL-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-205 | Mouse Anti-LRP6 Recombinant Antibody Fab Fragment (PFBC-205) | ELISA, WB, FC | Mouse Fab |
| HPAB-0007-FY-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (HPAB-0007-FY-F(E)) | ELISA | Human Fab |
| HPAB-0012-FY-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (HPAB-0012-FY-F(E)) | FuncS, Cyt | Human Fab |
| HPAB-0647-WJ-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (HPAB-0647-WJ-F(E)) | ELISA | Human Fab |
| HPAB-0648-WJ-F(E) | Human Anti-LRP6 Recombinant Antibody; Fab Fragment (HPAB-0648-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-205 | Mouse Anti-LRP6 Recombinant Antibody scFv Fragment (PSBC-205) | ELISA, WB, FC | Mouse scFv |
| HPAB-0647-WJ-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (HPAB-0647-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0648-WJ-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (HPAB-0648-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0649-WJ-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (HPAB-0649-WJ-S(P)) | ELISA | Human scFv |
| HPAB-0650-WJ-S(P) | Human Anti-LRP6 Recombinant Antibody; scFv Fragment (HPAB-0650-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2087 | Hi-Affi™ Recombinant Rabbit Anti-LRP6 Monoclonal Antibody (DS2087AB) | ICC, IF, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0647-WJ | Human Anti-LRP6 Recombinant Antibody (HPAB-0647-WJ) | ELISA | Human IgG |
| HPAB-0648-WJ | Human Anti-LRP6 Recombinant Antibody (HPAB-0648-WJ) | ELISA | Human IgG |
| HPAB-0649-WJ | Human Anti-LRP6 Recombinant Antibody (HPAB-0649-WJ) | ELISA | Human IgG |
| HPAB-0650-WJ | Human Anti-LRP6 Recombinant Antibody (HPAB-0650-WJ) | ELISA | Human IgG |
| HPAB-0651-WJ | Human Anti-LRP6 Recombinant Antibody (HPAB-0651-WJ) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NBD-0060-YJ-VHH | Camelid Anti-LRP6 Recombinant Single Domain Antibody (NBD-0060-YJ-VHH) | ELISA, Block | Camelid VHH |
| NBD-0061-YJ-VHH | Camelid Anti-LRP6 Recombinant Single Domain Antibody (NBD-0061-YJ-VHH) | ELISA, Block | Camelid VHH |
| NBD-0062-YJ-VHH | Camelid Anti-LRP6 Recombinant Single Domain Antibody (NBD-0062-YJ-VHH) | ELISA | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC367 | Recombinant Anti-LRP6 Vesicular Antibody, EV Displayed (VS-0425-YC367) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4100 | Anti-LRP6 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4101 | Anti-Human LRP6 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, IP, FC, FuncS, Neut, IF, WB
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
-2.png)
Application: FuncS, IF, Neut, ELISA, FC, IP, ICC
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: Neut, IHC, Activ, FuncS, IF, ELISA
Application: ELISA, FC, Neut, Inhib
Application: Inhib, FC, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
