Human Anti-LRP6 scFv-Fc Chimera (VS-0325-FY82) (CAT#: VS-0325-FY82)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human LRP6

• Species Reactivity
• Human

• Applications
• ELISA

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Alternative Names
• LRP-6

• Gene ID
• 4040

• UniProt ID
• O75581

• Long Name
• Low-density lipoprotein receptor-related protein 6

• Sequence Similarities
• Belongs to the LDLR family.

• Cellular Localization
• Cell membrane; Endoplasmic reticulum; Membrane raft

• Post Translation Modifications
• Dual phosphorylation of cytoplasmic PPPSP motifs sequentially by GSK3 and CK1 is required for AXIN1-binding, and subsequent stabilization and activation of beta-catenin via preventing GSK3-mediated phosphorylation of beta-catenin.
  Phosphorylated, in vitro, by GRK5/6 within and outside the PPPSP motifs.
  Phosphorylation at Ser-1490 by CDK14 during G2/M phase leads to regulation of the Wnt signaling pathway during the cell cycle.
  Phosphorylation by GSK3B is induced by RPSO1 binding and inhibited by DKK1.
  Phosphorylated, in vitro, by casein kinase I on Thr-1479.
  Undergoes gamma-secretase-dependent regulated intramembrane proteolysis (RIP).
  The extracellular domain is first released by shedding, and then, through the action of gamma-secretase, the intracellular domain (ICD) is released into the cytoplasm where it is free to bind to GSK3B and to activate canonical Wnt signaling.
  Palmitoylation on the two sites near the transmembrane domain leads to release of LRP6 from the endoplasmic reticulum.
  Mono-ubiquitinated which retains LRP6 in the endoplasmic reticulum.
  Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
  N-glycosylation is required for cell surface location.
  Glycosylation at Asn42, Asn81, Asn281, Asn433, Asn486, Asn692, Asn859, Asn865, Asn926, and Asn1039
  Ubiquitination at Lys1403
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 12 sites

• Protein Refseq
• XP_047284800.1; XP_054187674.1; XP_054228026.1; NP_001401173.1; NP_001401174.1

• Function
• Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation.
  The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalosomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin.

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

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