Human Anti-LY75 scFv-Fc Chimera (VS-0325-FY196)
CAT#: VS-0325-FY196
The anti-LY75 scFv-Fc antibody targets LY75 (Decay-accelerating factor), a complement regulatory protein. This antibody combines scFv specificity with Fc stability, making it a valuable tool for studying LY75's role in immune regulation, complement activation, and potential therapeutic applications in autoimmune and inflammatory diseases.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line
Immunofluorescent staining of human cell line CACO-2 shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54073/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows moderate cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human spleen
High expression. RNA expression: 18.4 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/ihc_selected.jpg
Normal Tissue
Figure 4 IHC staining of human skeletal muscle
Low expression. RNA expression: 0.3 nTPM
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_B_3_6_val_selected.jpg
Normal Tissue
Figure 5 Cerebral cortex
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_B_8_5.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_8_5.jpg
Normal Tissue
Figure 8 Testis
Elongated or late spermatids
Staining: Medium
Intensity: Moderate
Quantity:>75%
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49108/127068_A_5_6.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1450/4611_A_7_8.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (CAPAN-2, HDLM-2, Karpas-707, RT4, THP-1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000054219-LY75
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Specifications
- Immunogen
- The antigen was a soluble fusion protein comprising a DEC-205 extracellular domain (comprising all ten lectin-binding domains) fused with an antibody Fc domain.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human LY75
- Species Reactivity
- Human
- Applications
- ELISA, Flow Cytometry
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- DEC-205; CD205 protein
- UniProt ID
- Q6WY07
- Long Name
- lymphocyte antigen 75
- Cellular Localization
- Membrane
- Post Translation Modifications
- N-glycosylated.
Glycosylation at Asn135, Asn345, Asn377, Asn529, Asn843, Asn865, Asn934, Asn1076, Asn1103, Asn1225, Asn1320, Asn1392, Asn1593, Asn1626, and Asn1642
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect LY75_HUMAN (1472)
Glycosylation from GlyGen 21 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_002340.2
- Function
- Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Secondary Antibody
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- Product Name
See other products for "LY75"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-637 | Recombinant Anti-human LY75 Antibody | WB, Dot, FuncS | IgG |
| MOB-1020MZ | Recombinant Mouse Anti-Human LY75 Antibody (clone SD49) | IHC-Fr | Mouse antibody |
| HPAB-0470-YJ | Mouse Anti-LY75 Recombinant Antibody (HPAB-0470-YJ) | ELISA, IP, FuncS | Mouse IgG2a |
| HPAB-0471-YJ | Mouse Anti-LY75 Recombinant Antibody (HPAB-0471-YJ) | ELISA, IP, FuncS | Mouse IgG1 |
| FAMAB-1616CQ | Rat Anti-LY75 Recombinant Antibody (clone NLDC145) | IB, FC, IF, IHC | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-637-S(P) | Recombinant Anti-human LY75 Antibody scFv Fragment | FC, Neut, Biosensors, FuncS | scFv |
| MHH-637-S(P) | Recombinant Human Anti-human LY75 Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
| HPAB-0432LY-S(P) | Human Anti-LY75 Recombinant Antibody; scFv Fragment (HPAB-0432LY-S(P)) | ELISA | Human scfv |
| HPAB-0433LY-S(P) | Human Anti-LY75 Recombinant Antibody; scFv Fragment (HPAB-0433LY-S(P)) | ELISA | Human scfv |
| HPAB-0434LY-S(P) | Human Anti-LY75 Recombinant Antibody; scFv Fragment (HPAB-0434LY-S(P)) | ELISA | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2105 | Hi-Affi™ Recombinant Rabbit Anti-LY75 Monoclonal Antibody (DS2105AB) | IHC-P, IHC-Fr | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0432LY-F(E) | Human Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0432LY-F(E)) | ELISA | Human Fab |
| HPAB-0433LY-F(E) | Human Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0433LY-F(E)) | ELISA | Human Fab |
| HPAB-0434LY-F(E) | Human Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0434LY-F(E)) | ELISA | Human Fab |
| HPAB-0470-YJ-F(E) | Mouse Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0470-YJ-F(E)) | ELISA, IP, FuncS | Mouse Fab |
| HPAB-0471-YJ-F(E) | Mouse Anti-LY75 Recombinant Antibody; Fab Fragment (HPAB-0471-YJ-F(E)) | ELISA, IP, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC689 | Recombinant Anti-LY75 Vesicular Antibody, EV Displayed (VS-0425-YC689) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4139 | Anti-LY75 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4140 | Anti-Mouse LY75 Immunohistochemistry Kit | IHC |
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