Human Anti-MMP9 (clone DX-2802) scFv-Fc Chimera (CAT#: VS-0325-FY101)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human MMP9

• Species Reactivity
• Human

• Clone
• DX-2802

• Applications
• Western Blot, Inhibition

• Related Disease
• Cancer and inflammatory disorder

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Alternative Names
• Matrix Metallopeptidase 9; Matrix Metalloproteinase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase); EC 3.4.24.35; CLG4B; MMP-9; GELB; Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase); Matrix Metalloproteinase-9

• Gene ID
• 4318

• UniProt ID
• P14780

• Long Name
• Matrix Metallopeptidase 9

• Cellular Localization
• Secreted

• Post Translation Modifications
• Processing of the precursor yields different active forms of 64, 67 and 82 kDa.
  Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9.
  N- and O-glycosylated.
  Glycosylation at Asn38, Asn120, and Asn127
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect MMP9_HUMAN (6)
  Glycosylation from GlyGen 4 sites, 1 N-linked glycan (1 site), 29 O-linked glycans (1 site)

• Protein Refseq
• NP_004985.2

• Function
• Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (PubMed:2551898, 1480034, 12879005).
  Could play a role in bone osteoclastic resorption (By similarity).
  Cleaves KiSS1 at a Gly-|-Leu bond (PubMed:12879005).
  Cleaves NINJ1 to generate the Secreted ninjurin-1 form (PubMed:32883094).
  Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (PubMed:1480034).
  Degrades fibronectin but not laminin or Pz-peptide.

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

• HPAB-0199-FY
• Human Anti-MMP9 Recombinant Antibody (clone DX-2802)

• HPAB-0199-FY-S(P)
• Human Anti-MMP9 Recombinant Antibody (clone DX-2802); scFv Fragment

• HPAB-0199-FY-F(E)
• Human Anti-MMP9 Recombinant Antibody (clone DX-2802); Fab Fragment

• HPAB-0199-FY-mRNA
• Human Anti-MMP9 Antibody (clone DX-2802), mRNA

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