Human Anti-MPL (clone 5E5) scFv-Fc Chimera
CAT#: VS-0325-FY143
This product is a human scFv-Fc antibody that targets the human thrombopoietin receptor. It was originally identified from a combinatorial antibody library and exhibits high affinity for the receptor in its scFv-Fc format.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEL
Immunofluorescent staining of human cell line HEL shows localization to nuclear membrane & plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7619/1825_E1_28_cr5abb7d728bca3_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enriched (HEL)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117400-MPL
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human MPL
- Species Reactivity
- Human
- Clone
- 5E5
- Applications
- ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- MPL Proto-Oncogene, Thrombopoietin Receptor; Myeloproliferative Leukemia Virus Oncogene; Myeloproliferative Leukemia Protein; Proto-Oncogene C-Mpl; TPO-R; TPOR; Thrombopoietin Receptor
- Gene ID
- 4352
- UniProt ID
- P40238
- Long Name
- MPL Proto-Oncogene, Thrombopoietin Receptor
- Sequence Similarities
- Belongs to the type I cytokine receptor family. Type 1 subfamily.
- Cellular Localization
- Cell membrane; Golgi apparatus; Membrane
- Post Translation Modifications
- Ubiquitination at Lys-553 and Lys-573 targets MPL for degradation by both the lysosomal and proteasomal pathways.
The E3 ubiquitin-protein ligase CBL significantly contributes to this ubiquitination.
- Protein Refseq
- NP_005364.1
- Function
- Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "Clone 5E5"
- CAT
- Product Name
See other products for "MPL"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-155CQ | Human Anti-MPL Recombinant Antibody (TAB-155CQ) | ELISA, FC, FuncS | Human IgG1 |
| TAB-155CQ-S(P) | Human Anti-MPL Recombinant Antibody; scFv Fragment (TAB-155CQ-S(P)) | ELISA, FC, WB | Human scFv |
| TAB-155CQ-F(E) | Human Anti-MPL Recombinant Antibody; Fab Fragment (TAB-155CQ-F(E)) | ELISA, FC, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-156CQ | Anti-Human MPL Recombinant Antibody (TA136) | ELISA, FC | |
| TAB-157CQ | Anti-Human MPL Recombinant Antibody (VB22B) | ELISA, FC | |
| TAB-156CQ-S(P) | Anti-Human MPL Recombinant Antibody scFv Fragment (TA136) | ELISA, FC | |
| TAB-156CQ-F(E) | Anti-Human MPL Recombinant Antibody Fab Fragment (TA136) | ELISA, FC | |
| TAB-157CQ-F(E) | Anti-Human MPL Recombinant Antibody Fab Fragment (VB22B) | ELISA, FC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2272 | Hi-Affi™ Recombinant Rabbit Anti-MPL Monoclonal Antibody (DS2272AB) | FC, WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-108LC | Recombinant Human Anti-Human MPL Agonist Antibody (12B5) | FC, FunS, ELISA | Human antibody |
| MOB-109LC | Recombinant Human Anti-Human MPL Agonist Antibody (12D5) | FC, FunS, ELISA | Human antibody |
| MOB-110LC | Recombinant Human Anti-Human MPL Agonist Antibody (12E10) | FC, FunS, ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0566-CN-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0566-CN-F(E)) | ELISA, FC, Block | Mouse Fab |
| HPAB-0567-CN-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-0567-CN-F(E)) | ELISA, FC, Block | Mouse Fab |
| HPAB-S0095-YC-F(E) | Human Anti-MPL Recombinant Antibody (clone 10F6); Fab Fragment | ELISA, Agonist | Human Fab |
| HPAB-S0096-YC-F(E) | Human Anti-MPL Recombinant Antibody (clone 10D10); Fab Fragment | ELISA, Agonist | Human Fab |
| HPAB-S0097-YC-F(E) | Human Anti-MPL Recombinant Antibody (clone 5E5); Fab Fragment | ELISA, Agonist | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1580-FY | Mouse Anti-MPL Recombinant Antibody (HPAB-1580-FY) | WB, FC, ELISA | Mouse IgG |
| HPAB-1581-FY | Mouse Anti-MPL Recombinant Antibody (HPAB-1581-FY) | FC | Mouse IgG |
| HPAB-1582-FY | Mouse Anti-MPL Recombinant Antibody (HPAB-1582-FY) | ELISA | Mouse IgG |
| VS3-XY1093 | Mouse Anti-MPL Recombinant Antibody (clone 1H2) | ELISA, WB, FC | Mouse IgG2b |
| VS3-FY1910 | Rabbit Anti-MPL Recombinant Antibody (clone R03-1C9) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1580-FY-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-1580-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-1581-FY-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-1581-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-1582-FY-F(E) | Mouse Anti-MPL Recombinant Antibody; Fab Fragment (HPAB-1582-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-S0095-YC-S(P) | Human Anti-MPL Recombinant Antibody (clone 10F6); scFv Fragment | ELISA, Agonist | Human scFv |
| HPAB-S0096-YC-S(P) | Human Anti-MPL Recombinant Antibody (clone 10D10); scFv Fragment | ELISA, Agonist | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC552 | Recombinant Anti-MPL Vesicular Antibody, EV Displayed (VS-0425-YC552) | Block, ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC127 | Recombinant Anti-MPL (Bin I x Bin II) Biparatopic Antibody, Tandem scFv | Block, ELISA, FC | Tandem scFv |
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