Human Anti-MPL (clone 5E5) scFv-Fc Chimera (CAT#: VS-0325-FY143)
This product is a human scFv-Fc antibody that targets the human thrombopoietin receptor. It was originally identified from a combinatorial antibody library and exhibits high affinity for the receptor in its scFv-Fc format.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to nuclear membrane & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7619/1825_E1_28_cr5abb7d728bca3_selected.jpg
(Immunofluorescent staining of human cell line HEL shows localization to nuclear membrane & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/7619/1825_E1_28_cr5abb7d728bca3_selected.jpg
Figure 2 RNA cell line category: Cell line enriched (HEL)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117400-MPL
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000117400-MPL
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human MPL
- Species Reactivity
- Human
- Clone
- 5E5
- Applications
- ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- MPL Proto-Oncogene, Thrombopoietin Receptor; Myeloproliferative Leukemia Virus Oncogene; Myeloproliferative Leukemia Protein; Proto-Oncogene C-Mpl; TPO-R; TPOR; Thrombopoietin Receptor
- Gene ID
- 4352
- UniProt ID
- P40238
- Long Name
- MPL Proto-Oncogene, Thrombopoietin Receptor
- Sequence Similarities
- Belongs to the type I cytokine receptor family. Type 1 subfamily.
- Cellular Localization
- Cell membrane; Golgi apparatus; Membrane
- Post Translation Modifications
- Ubiquitination at Lys-553 and Lys-573 targets MPL for degradation by both the lysosomal and proteasomal pathways.
The E3 ubiquitin-protein ligase CBL significantly contributes to this ubiquitination.
- Protein Refseq
- NP_005364.1
- Function
- Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2377z | Mouse Anti-MPL Recombinant Antibody (clone 42A11) | WB, ELISA, FC, ICC, IF, IHC | Mouse IgG1 |
| HPAB-1580-FY | Mouse Anti-MPL Recombinant Antibody (HPAB-1580-FY) | WB, FC, ELISA | Mouse IgG |
| HPAB-1581-FY | Mouse Anti-MPL Recombinant Antibody (HPAB-1581-FY) | FC | Mouse IgG |
| HPAB-1582-FY | Mouse Anti-MPL Recombinant Antibody (HPAB-1582-FY) | ELISA | Mouse IgG |
| VS3-XY1093 | Mouse Anti-MPL Recombinant Antibody (clone 1H2) | ELISA, WB, FC | Mouse IgG2b |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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