Human Anti-MSTN (clone Domagrozumab) scFv-Fc Chimera

Name: Human Anti-MSTN (clone Domagrozumab) scFv-Fc Chimera
SKU: VS-0325-FY4
Rating: 5 (1 reviews)

CAT#: VS-0325-FY4

GDF-8, also known as myostatin, is a member of the TGF-β superfamily and is primarily expressed in muscle tissues, where it regulates muscle growth and differentiation. Overexpression of GDF-8 is associated with muscle wasting and related disorders. The GDF-8 scFv-Fc is a recombinant protein designed to specifically bind and neutralize GDF-8, thus inhibiting its biological function. This fusion protein consists of a single-chain variable fragment linked to the Fc region of an immunoglobulin, enhancing stability and serum half-life. In research, GDF-8 scFv-Fc can be used to investigate muscle biology and the role of muscle growth factors in various diseases. Therapeutically, it holds promise for treating muscle-wasting diseases like cachexia, muscular dystrophy, and age-related sarcopenia. Additionally, it may be explored for muscle enhancement in conditions requiring muscle regeneration and repair.

Gene Expression

Normal Tissue Figure 1 IHC staining of human skeletal muscle

Immunohistochemical staining of human skeletal muscle shows strong plasma positivity.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9963/166785_B_1_6_selected.jpg

RNA Expression Figure 2 RNA cell line category: Group enriched (LHCN-M2, RH-30)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000138379-MSTN

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Specifications

Immunogen
Human MSTN protein

Host Species
Human

Type
Human IgG1, scFv-Fc

Antibody Isotype
scFv-Fc

Specificity
Human MSTN

Species Reactivity
Human

Clone
Domagrozumab

Applications
ELISA

Related Disease
Duchenne muscular dystrophy (DMD)

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Shipping
Ice packs

Target

Alternative Names
Myostatin; GDF8; Growth Differentiation Factor 8; Growth/Differentiation Factor 8; MSLHP; GDF-8

Gene ID
2660

UniProt ID
O14793

Long Name
Myostatin

Sequence Similarities
Belongs to the TGF-beta family.

Cellular Localization
Secreted

Post Translation Modifications
Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule.
The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state.
Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.
Glycosylation at Asn71
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site, 1 N-linked glycan (1 site)

Protein Refseq
NP_005250.1

Function
Acts specifically as a negative regulator of skeletal muscle growth.

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS-0325-FY4.pdf

MSDS

MSDS - VS-0325-FY4.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Isotype Control

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Secondary Antibody

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