Human Anti-MSTN (clone Domagrozumab) scFv-Fc Chimera (CAT#: VS-0325-FY4)
GDF-8, also known as myostatin, is a member of the TGF-β superfamily and is primarily expressed in muscle tissues, where it regulates muscle growth and differentiation. Overexpression of GDF-8 is associated with muscle wasting and related disorders. The GDF-8 scFv-Fc is a recombinant protein designed to specifically bind and neutralize GDF-8, thus inhibiting its biological function. This fusion protein consists of a single-chain variable fragment linked to the Fc region of an immunoglobulin, enhancing stability and serum half-life. In research, GDF-8 scFv-Fc can be used to investigate muscle biology and the role of muscle growth factors in various diseases. Therapeutically, it holds promise for treating muscle-wasting diseases like cachexia, muscular dystrophy, and age-related sarcopenia. Additionally, it may be explored for muscle enhancement in conditions requiring muscle regeneration and repair.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human skeletal muscle
(Immunohistochemical staining of human skeletal muscle shows strong plasma positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9963/166785_B_1_6_selected.jpg
(Immunohistochemical staining of human skeletal muscle shows strong plasma positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9963/166785_B_1_6_selected.jpg
Figure 2 RNA cell line category: Group enriched (LHCN-M2, RH-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000138379-MSTN
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000138379-MSTN
Specifications
- Immunogen
- Human MSTN protein
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human MSTN
- Species Reactivity
- Human
- Clone
- Domagrozumab
- Applications
- ELISA
- Related Disease
- Duchenne muscular dystrophy (DMD)
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Myostatin; GDF8; Growth Differentiation Factor 8; Growth/Differentiation Factor 8; MSLHP; GDF-8
- Gene ID
- 2660
- UniProt ID
- O14793
- Long Name
- Myostatin
- Sequence Similarities
- Belongs to the TGF-beta family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule.
The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state.
Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.
Glycosylation at Asn71
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site, 1 N-linked glycan (1 site)
- Protein Refseq
- NP_005250.1
- Function
- Acts specifically as a negative regulator of skeletal muscle growth.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Mouse Antibody Products
Humanized Antibody Products
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Human Antibody Products
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Fab Antibody Products
ScFv Antibody Products
Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0476CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0476CL) | ELISA, WB | Mouse IgG |
| TAB-0477CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0477CL) | ELISA, WB | Mouse IgG |
| TAB-0478CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0478CL) | ELISA, WB | Mouse IgG |
| TAB-0479CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0479CL) | ELISA, WB | Mouse IgG |
| TAB-0480CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0480CL) | ELISA, WB | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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