Human Anti-MSTN (clone Domagrozumab) scFv-Fc Chimera
CAT#: VS-0325-FY4
GDF-8, also known as myostatin, is a member of the TGF-β superfamily and is primarily expressed in muscle tissues, where it regulates muscle growth and differentiation. Overexpression of GDF-8 is associated with muscle wasting and related disorders. The GDF-8 scFv-Fc is a recombinant protein designed to specifically bind and neutralize GDF-8, thus inhibiting its biological function. This fusion protein consists of a single-chain variable fragment linked to the Fc region of an immunoglobulin, enhancing stability and serum half-life. In research, GDF-8 scFv-Fc can be used to investigate muscle biology and the role of muscle growth factors in various diseases. Therapeutically, it holds promise for treating muscle-wasting diseases like cachexia, muscular dystrophy, and age-related sarcopenia. Additionally, it may be explored for muscle enhancement in conditions requiring muscle regeneration and repair.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human skeletal muscle
Immunohistochemical staining of human skeletal muscle shows strong plasma positivity.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9963/166785_B_1_6_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (LHCN-M2, RH-30)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000138379-MSTN
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Specifications
- Immunogen
- Human MSTN protein
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human MSTN
- Species Reactivity
- Human
- Clone
- Domagrozumab
- Applications
- ELISA
- Related Disease
- Duchenne muscular dystrophy (DMD)
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Myostatin; GDF8; Growth Differentiation Factor 8; Growth/Differentiation Factor 8; MSLHP; GDF-8
- Gene ID
- 2660
- UniProt ID
- O14793
- Long Name
- Myostatin
- Sequence Similarities
- Belongs to the TGF-beta family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule.
The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state.
Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.
Glycosylation at Asn71
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site, 1 N-linked glycan (1 site)
- Protein Refseq
- NP_005250.1
- Function
- Acts specifically as a negative regulator of skeletal muscle growth.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "MSTN"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0476CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0476CL) | ELISA, WB | Mouse IgG |
| TAB-0477CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0477CL) | ELISA, WB | Mouse IgG |
| TAB-0478CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0478CL) | ELISA, WB | Mouse IgG |
| TAB-0479CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0479CL) | ELISA, WB | Mouse IgG |
| TAB-0480CL | Mouse Anti-MSTN Recombinant Antibody (TAB-0480CL) | ELISA, WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-451MZ | Human Anti-MSTN Recombinant Antibody (TAB-451MZ) | FuncS, Inhib | Humanized IgG4 |
| TAB-457MZ | Anti-Human MSTN Recombinant Antibody (H0L0) | ELISA, FuncS, Inhib | Humanized antibody |
| TAB-458MZ | Anti-Human MSTN Recombinant Antibody (H1L2) | ELISA | Humanized antibody |
| TAB-459MZ | Anti-Human MSTN Recombinant Antibody (H2L2) | ELISA, FuncS, Inhib | Humanized antibody |
| TAB-451MZ-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (TAB-451MZ-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-452MZ | Human Anti-MSTN Recombinant Antibody (TAB-452MZ) | FuncS, Inhib | Human IgG4, λ |
| TAB-453MZ | Human Anti-MSTN Recombinant Antibody (TAB-453MZ) | FuncS, Inhib | Human IgG4, λ |
| TAB-454MZ | Anti-Human MSTN Recombinant Antibody (F1-10) | SDS-PAGE, WB, ELISA | Human antibody |
| TAB-460MZ | Human Anti-MSTN Recombinant Antibody (TAB-460MZ) | ELISA, FuncS | Human IgG |
| TAB-461MZ | Human Anti-MSTN Recombinant Antibody (TAB-461MZ) | ELISA, FuncS, Inhib | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-456MZ | Anti-Human MSTN Recombinant Antibody (10B3C) | FuncS, Inhib | Chimeric antibody (mouse/human) |
| TAB-456MZ-S(P) | Anti-Human MSTN Recombinant Antibody scFv Fragment (10B3C) | ELISA | Chimeric antibody (mouse/human) |
| TAB-456MZ-F(E) | Anti-Human MSTN Recombinant Antibody Fab Fragment (10B3C) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0276LY-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-0276LY-S(P)) | ELISA, Neut, in vivo effect | Humanized scfv |
| HPAB-0277LY-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-0277LY-S(P)) | ELISA | Humanized scfv |
| HPAB-0659-WJ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-0659-WJ-S(P)) | WB | Human scFv |
| HPAB-0660-WJ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-0660-WJ-S(P)) | WB | Human scFv |
| HPAB-0661-WJ-S(P) | Human Anti-MSTN Recombinant Antibody; scFv Fragment (HPAB-0661-WJ-S(P)) | WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0276LY-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0276LY-F(E)) | ELISA, Neut, in vivo effect | Humanized Fab |
| HPAB-0277LY-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0277LY-F(E)) | ELISA | Humanized Fab |
| HPAB-0580YY-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0580YY-F(E)) | ELISA, FuncS | Humanized Fab |
| HPAB-0583YY-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0583YY-F(E)) | ELISA, FuncS | Humanized Fab |
| HPAB-0584YY-F(E) | Human Anti-MSTN Recombinant Antibody; Fab Fragment (HPAB-0584YY-F(E)) | ELISA, FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP389-YC | Human Anti-MSTN Recombinant Antibody (HPAB-AP389-YC) | ELISA, Neut | Humanized IgG |
| HPAB-AP390-YC | Human Anti-MSTN Recombinant Antibody (HPAB-AP390-YC) | ELISA, Neut | Humanized IgG |
| HPAB-AP391-YC | Human Anti-MSTN Recombinant Antibody (HPAB-AP391-YC) | ELISA, Neut | Humanized IgG |
| HPAB-AP392-YC | Human Anti-MSTN Recombinant Antibody (HPAB-AP392-YC) | ELISA, Neut | Humanized IgG |
| HPAB-AP393-YC | Human Anti-MSTN Recombinant Antibody (HPAB-AP393-YC) | ELISA, Neut | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY191 | AbPlus™ Anti-MSTN Magnetic Beads (VS-0424-XY191) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4550 | Anti-MSTN Immunohistochemistry Kit | IHC | |
| VS-0525-XY4551 | Anti-Mouse MSTN Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC231 | Recombinant Anti-MSTN Eliminating Antibody, pH-Sensitive (VS-0625-YC231) | Antigen-Sweeping In Vivo. | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0825-YC260 | SmartAb™ Recombinant Anti-MSTN pH-dependent Antibody (Clone F1-10) | WB, ELISA | Human IgG |
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