Human Anti-MSTN (clone Domagrozumab) scFv-Fc Chimera (CAT#: VS-0325-FY4)
GDF-8, also known as myostatin, is a member of the TGF-β superfamily and is primarily expressed in muscle tissues, where it regulates muscle growth and differentiation. Overexpression of GDF-8 is associated with muscle wasting and related disorders. The GDF-8 scFv-Fc is a recombinant protein designed to specifically bind and neutralize GDF-8, thus inhibiting its biological function. This fusion protein consists of a single-chain variable fragment linked to the Fc region of an immunoglobulin, enhancing stability and serum half-life. In research, GDF-8 scFv-Fc can be used to investigate muscle biology and the role of muscle growth factors in various diseases. Therapeutically, it holds promise for treating muscle-wasting diseases like cachexia, muscular dystrophy, and age-related sarcopenia. Additionally, it may be explored for muscle enhancement in conditions requiring muscle regeneration and repair.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human skeletal muscle
(Immunohistochemical staining of human skeletal muscle shows strong plasma positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9963/166785_B_1_6_selected.jpg
(Immunohistochemical staining of human skeletal muscle shows strong plasma positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9963/166785_B_1_6_selected.jpg
Figure 2 RNA cell line category: Group enriched (LHCN-M2, RH-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000138379-MSTN
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000138379-MSTN
Specifications
- Immunogen
- Human MSTN protein
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human MSTN
- Species Reactivity
- Human
- Clone
- Domagrozumab
- Applications
- ELISA
- Related Disease
- Duchenne muscular dystrophy (DMD)
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Myostatin; GDF8; Growth Differentiation Factor 8; Growth/Differentiation Factor 8; MSLHP; GDF-8
- Gene ID
- 2660
- UniProt ID
- O14793
- Long Name
- Myostatin
- Sequence Similarities
- Belongs to the TGF-beta family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule.
The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state.
Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase.
Glycosylation at Asn71
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site, 1 N-linked glycan (1 site)
- Protein Refseq
- NP_005250.1
- Function
- Acts specifically as a negative regulator of skeletal muscle growth.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Mouse Antibody Products
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0476CL-S(P) | Mouse Anti-MSTN Recombinant Antibody; scFv Fragment (TAB-0476CL-S(P)) | ELISA, WB | Mouse scFv |
| TAB-0477CL-S(P) | Mouse Anti-MSTN Recombinant Antibody; scFv Fragment (TAB-0477CL-S(P)) | ELISA, WB | Mouse scFv |
| TAB-0478CL-S(P) | Mouse Anti-MSTN Recombinant Antibody; scFv Fragment (TAB-0478CL-S(P)) | ELISA, WB | Mouse scFv |
| TAB-0479CL-S(P) | Mouse Anti-MSTN Recombinant Antibody; scFv Fragment (TAB-0479CL-S(P)) | ELISA, WB | Mouse scFv |
| TAB-0480CL-S(P) | Mouse Anti-MSTN Recombinant Antibody; scFv Fragment (TAB-0480CL-S(P)) | ELISA, WB | Mouse scFv |
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