Human Anti-MUC5AC (clone Ensituximab) scFv-Fc Chimera
CAT#: VS-0425-FY153
The anti-MUC5AC scFv-FC targets MUC5AC, a mucin protein overexpressed in various respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD). This fusion protein aims to neutralize MUC5AC, which could help reduce excessive mucus production and improve respiratory function.
Gene Expression
Normal Tissue
Figure 1 High expression in stomach 1
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40615/124256_A_6_1_val_selected.jpg
Normal Tissue
Figure 2 Low expression in liver
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40615/124256_A_9_4_val_selected.jpg
Normal Tissue
Figure 3 Stomach
Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/40615/124256_A_3_1.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (A549, OE19)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000215182-MUC5AC
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Specifications
- Immunogen
- Human MU5AC as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human MUC5AC
- Species Reactivity
- Human
- Clone
- Ensituximab
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Dry Eye Syndrome; Biliary Tract Disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Mucin 5AC, Oligomeric Mucus/Gel-Forming; Mucin 5, Subtypes A And C, Tracheobronchial/Gastric; Mucin-5 Subtype AC, Tracheobronchial; Lewis B Blood Group Antigen; Major Airway Glycoprotein; Tracheobronchial Mucin; Gastric Mucin; MUC5
- Gene ID
- 4586
- UniProt ID
- P98088
- Long Name
- Mucin 5AC, Oligomeric Mucus/Gel-Forming
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn205, Asn258, Asn415, Asn524, Asn1308, Trp1389, Trp1584, Trp1749, Trp1957, Trp2122, Thr2395, Thr2405, Thr2451, Thr2461, Thr2531, Thr2541, Thr2571, Thr2581, Thr2699, Thr2709, Thr2883, Thr2893, Thr2979, Thr2989, Thr3067, Thr3077, Trp3228, Trp3526, Asn3774, Trp3959, Thr4224, Thr4234, Thr4296, Thr4306, Thr4320, Thr4330, Thr4376, Thr4386, Thr4440, Thr4450, Thr4480, Thr4490, Thr4512, Thr4522, Thr4568, Thr4578, Trp4633, Asn4869, Asn4942, Asn5057, Asn5093, Asn5236, Asn5347, Asn5377, Asn5386, Asn5455, Asn5528, and Asn5591
Glycosylation from GlyConnect MUC5A_HUMAN (375)
Glycosylation from GlyGen 63 sites, 17 O-linked glycans (1 site)
- Protein Refseq
- NP_001291288.1
- Function
- Gel-forming glycoprotein of gastric and respiratory tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microorganisms and particles that are subsequently removed by the mucociliary system.
Interacts with H.pylori in the gastric epithelium, Barrett's esophagus as well as in gastric metaplasia of the duodenum (GMD).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "MUC5AC"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-200 | Anti-Human MUC5AC Recombinant Antibody (TAB-200) | IP, IF, FuncS, FC, Neut, ELISA, ICC | IgG1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-404MZ | Mouse Anti-MUC5AC Recombinant Antibody (TAB-404MZ) | ELISA, Inhib, IHC, IA | Mouse IgG |
| TAB-404MZ-S(P) | Mouse Anti-MUC5AC Recombinant Antibody; scFv Fragment (TAB-404MZ-S(P)) | IHC | Mouse scFv |
| TAB-404MZ-F(E) | Mouse Anti-MUC5AC Recombinant Antibody; Fab Fragment (TAB-404MZ-F(E)) | IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-405MZ | Human Anti-MUC5AC Recombinant Antibody (TAB-405MZ) | IF, WB, IHC, IA | Humanized IgG |
| TAB-406MZ | Anti-Human MUC5AC Recombinant Antibody (VH-1) | FC, ELISA | Humanized antibody |
| TAB-405MZ-S(P) | Human Anti-MUC5AC Recombinant Antibody; scFv Fragment (TAB-405MZ-S(P)) | IHC | Humanized scFv |
| TAB-405MZ-F(E) | Human Anti-MUC5AC Recombinant Antibody; Fab Fragment (TAB-405MZ-F(E)) | IHC | Humanized Fab |
| TAB-406MZ-F(E) | Anti-Human MUC5AC Recombinant Antibody Fab Fragment (VH-1) | FC, ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1265CT | Recombinant Mouse anti-Human MUC5AC Monoclonal antibody (2-24N2) | ELISA, ICC, IHC-Fr, IHC-P, WB | |
| HPAB-AP150-YC | Human Anti-MUC5AC Recombinant Antibody (clone Antibody 1) | ELISA, Cyt | Human IgG |
| HPAB-AP151-YC | Human Anti-MUC5AC Recombinant Antibody (clone Antibody 10) | ELISA, Cyt | Human IgG |
| HPAB-0566-YJ | Mouse Anti-MUC5AC Recombinant Antibody (HPAB-0566-YJ) | WB, IHC, ELISA | Mouse IgG1 |
| VS3-WK138 | Mouse Anti-MUC5AC Recombinant Antibody (clone G6-H8) | WB, ELISA | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0585CQ | Recombinant Mouse Anti-Human MUC5AC Antibody (19-O Le) | ELISA | IgM |
| EPAF-0586CQ | Recombinant Mouse Anti-Human MUC5AC Antibody (2-25 Le) | ELISA | IgG1 |
| EPAF-0587CQ | Recombinant Mouse Anti-Human MUC5AC Antibody (7 Le) | ELISA | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0340LY-S(P) | Mouse Anti-MUC5AC Recombinant Antibody (clone 58-1066); scfv Fragment | ELISA | Mouse scfv |
| HPAB-AP150-YC-S(P) | Human Anti-MUC5AC Recombinant Antibody (clone Antibody 1); scFv Fragment | ELISA, Cyt | Human scFv |
| HPAB-AP151-YC-S(P) | Human Anti-MUC5AC Recombinant Antibody (clone Antibody 10); scFv Fragment | ELISA, Cyt | Human scFv |
| HPAB-0566-YJ-S(P) | Mouse Anti-MUC5AC Recombinant Antibody; scFv Fragment (HPAB-0566-YJ-S(P)) | WB, ELISA, Inhib, IP, IHC, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0340LY-F(E) | Mouse Anti-MUC5AC Recombinant Antibody (clone 58-1066); Fab Fragment | ELISA | Mouse Fab |
| HPAB-AP150-YC-F(E) | Human Anti-MUC5AC Recombinant Antibody (clone Antibody 1); Fab Fragment | ELISA, Cyt | Human Fab |
| HPAB-AP151-YC-F(E) | Human Anti-MUC5AC Recombinant Antibody (clone Antibody 10); Fab Fragment | ELISA, Cyt | Human Fab |
| HPAB-0566-YJ-F(E) | Mouse Anti-MUC5AC Recombinant Antibody; Fab Fragment (HPAB-0566-YJ-F(E)) | WB, ELISA, Inhib, IP, IHC, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-200 | Afuco™ Anti-MUC5AC ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-200) | IP, IF, FuncS, FC, Neut, ELISA | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1061 | PE-B*07:02/Human MUC5AC (SPFFLLLLL) MHC Tetramer | FCM, IHC | |
| MHC-CN1062 | APC-B*07:02/Human MUC5AC (SPFFLLLLL) MHC Tetramer | FCM, IHC | |
| MHC-CN1063 | FITC-B*07:02/Human MUC5AC (SPFFLLLLL) MHC Tetramer | FCM, IHC | |
| MHC-CN1064 | B*07:02/Human MUC5AC (SPFFLLLLL) MHC Tetramer | FCM, IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY330 | Mouse Anti-NHP MUC5AC Recombinant Antibody (clone 45M1) | IHC, ICC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY4584 | Anti-MUC5AC Immunohistochemistry Kit | IHC | |
| VS-0525-XY4585 | Anti-Mouse MUC5AC Immunohistochemistry Kit | IHC |
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