Human Anti-NCAM1 (clone huN901) scFv-Fc Chimera (CAT#: VS-0425-FY89)
NCAM1 (Neural cell adhesion molecule 1) is involved in neuronal development and cell-cell interactions. This scFv-Fc fusion protein targets NCAM1 and is being explored for its potential use in neurodegenerative diseases and cancer.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39835/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39835/if_selected.jpg
Figure 2 Cerebral cortex
(Neuropil
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39835/100448_B_9_5.jpg
(Neuropil
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39835/100448_B_9_5.jpg
Figure 3 Colon
(Peripheral nerve/ganglion
Staining:
High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39835/100448_A_8_3.jpg
(Peripheral nerve/ganglion
Staining:
High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39835/100448_A_8_3.jpg
Figure 4 Soft tissue
(Peripheral nerve
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39835/100448_B_1_7.jpg
(Peripheral nerve
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/39835/100448_B_1_7.jpg
Figure 5 RNA cell line category: Cell line enhanced (HEL, RH-30, SCLC-21H, SH-SY5Y, U-138 MG, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000149294-NCAM1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000149294-NCAM1
Figure 5 RNA cell line category: Cell line enhanced (HEL, RH-30, SCLC-21H, SH-SY5Y, U-138 MG, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000149294-NCAM1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000149294-NCAM1
Specifications
- Immunogen
- The original antibody (N901), from which huN901 was derived, was raised against CD56 expressed on tumors of neuroendocrine origin.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- It specifically binds to CD56
- Species Reactivity
- Human
- Clone
- huN901
- Applications
- Western Blot, Dot Blot, ELISA
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Dot Blot: 2 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Neural Cell Adhesion Molecule 1; NCAM; Antigen Recognized By Monoclonal Antibody 5.1H11; Neural Cell Adhesion Molecule, NCAM; CD56 Antigen; N-CAM-1; NCAM-1; MSK39; CD56
- Gene ID
- 4684
- UniProt ID
- P13591
- Long Name
- Neural Cell Adhesion Molecule 1
- Cellular Localization
- Cell membrane, Membrane, Secreted
- Function
- The NCAM1 gene encodes the neural cell adhesion molecule 1 (NCAM1), a cell surface glycoprotein belonging to the immunoglobulin superfamily. NCAM1 is crucial for cell-to-cell interactions, particularly in the nervous system and during development. It mediates homophilic (like-like) binding between neurons and between neurons and muscle cells, playing a vital role in neurite outgrowth, axon guidance, and synaptic plasticity.
Beyond the nervous system, NCAM1 (also known as CD56) is involved in the expansion of T lymphocytes, B lymphocytes, and natural killer (NK) cells, contributing to immune surveillance. It interacts with fibroblast growth factor receptors (FGFRs) and other extracellular matrix components, influencing signal transduction pathways involved in cell growth and differentiation. Aberrant expression of NCAM1 is implicated in various neurological disorders and cancers.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-188 | Humanized Anti-NCAM1 Recombinant Antibody (clone Lorvotuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | Humanized (from mouse) IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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