Human Anti-NGF scFv-Fc Chimera (VS-0425-FY156)

CAT#: VS-0425-FY156

The anti-NGF (nerve growth factor) scFv-FC is a recombinant construct that features a single-chain variable fragment specific to NGF fused to the FC region. NGF is vital for the growth, maintenance, and survival of certain neurons and has been implicated in pain signaling. This scFv-FC has potential applications in pain management and neurodegenerative diseases, as it can modulate NGF activity, providing a targeted approach to treating conditions like chronic pain and neuropathy.

Gene Expression
Figure 1 RNA cell line category: Cell line enhanced.

Specifications

  • Immunogen
  • Human NGF as an immunogen.
  • Host Species
  • Human
  • Type
  • Human IgG2, scFv-Fc
  • Specificity
  • Human NGF
  • Species Reactivity
  • Human
  • Applications
  • Neutralization, ELISA
  • Related Disease
  • Bone cancer

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • The optimal dilution concentration is determined by the experiment.

Target

  • Alternative Names
  • Nerve Growth Factor; Nerve Growth Factor (Beta Polypeptide); Beta-NGF; NGFB; Nerve Growth Factor, Beta Subunit; Beta-Nerve Growth Factor; HSAN5
  • Long Name
  • Nerve Growth Factor
  • Sequence Similarities
  • Belongs to the NGF-beta family.
  • Cellular Localization
  • Endosome, Secreted
  • Post Translation Modifications
  • Glycosylation at Ser43, Thr46, Asn69, and Asn114
    Modification sites at PhosphoSitePlus
    Glycosylation from GlyGen 5 sites, 1 O-linked glycan (3 sites)
  • Function
  • Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse.
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

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COA

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