Human Anti-NGF scFv-Fc Chimera (VS-0425-FY156)

Name: Human Anti-NGF scFv-Fc Chimera (VS-0425-FY156)
SKU: VS-0425-FY156
Rating: 5 (1 reviews)

CAT#: VS-0425-FY156

The anti-NGF (nerve growth factor) scFv-FC is a recombinant construct that features a single-chain variable fragment specific to NGF fused to the FC region. NGF is vital for the growth, maintenance, and survival of certain neurons and has been implicated in pain signaling. This scFv-FC has potential applications in pain management and neurodegenerative diseases, as it can modulate NGF activity, providing a targeted approach to treating conditions like chronic pain and neuropathy.

Gene Expression

RNA Expression Figure 1 RNA cell line category: Cell line enhanced.

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134259-NGF

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Specifications

Immunogen
Human NGF as an immunogen.

Host Species
Human

Type
Human IgG2, scFv-Fc

Antibody Isotype
scFv-Fc

Specificity
Human NGF

Species Reactivity
Human

Applications
Neutralization, ELISA

Related Disease
Bone cancer

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Shipping
Ice packs

Applications

Application Notes
The optimal dilution concentration is determined by the experiment.

Target

Alternative Names
Nerve Growth Factor; Nerve Growth Factor (Beta Polypeptide); Beta-NGF; NGFB; Nerve Growth Factor, Beta Subunit; Beta-Nerve Growth Factor; HSAN5

Gene ID
4803

UniProt ID
P01138

Long Name
Nerve Growth Factor

Sequence Similarities
Belongs to the NGF-beta family.

Cellular Localization
Endosome, Secreted

Post Translation Modifications
Glycosylation at Ser43, Thr46, Asn69, and Asn114
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 5 sites, 1 O-linked glycan (3 sites)

Protein Refseq
XP_006710726.1; XP_011539820.1; XP_054192764.1; XP_054192765.1; NP_002497.2

Function
Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse.

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS-0425-FY156.pdf

MSDS

MSDS - VS-0425-FY156.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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