Human Anti-NGF scFv-Fc Chimera (VS-0425-FY156) (CAT#: VS-0425-FY156)
The anti-NGF (nerve growth factor) scFv-FC is a recombinant construct that features a single-chain variable fragment specific to NGF fused to the FC region. NGF is vital for the growth, maintenance, and survival of certain neurons and has been implicated in pain signaling. This scFv-FC has potential applications in pain management and neurodegenerative diseases, as it can modulate NGF activity, providing a targeted approach to treating conditions like chronic pain and neuropathy.
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RNA Expression
Figure 1 RNA cell line category: Cell line enhanced.
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134259-NGF
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134259-NGF
Specifications
- Immunogen
- Human NGF as an immunogen.
- Host Species
- Human
- Type
- Human IgG2, scFv-Fc
- Specificity
- Human NGF
- Species Reactivity
- Human
- Applications
- Neutralization, ELISA
- Related Disease
- Bone cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Nerve Growth Factor; Nerve Growth Factor (Beta Polypeptide); Beta-NGF; NGFB; Nerve Growth Factor, Beta Subunit; Beta-Nerve Growth Factor; HSAN5
- Gene ID
- 4803
- UniProt ID
- P01138
- Long Name
- Nerve Growth Factor
- Sequence Similarities
- Belongs to the NGF-beta family.
- Cellular Localization
- Endosome, Secreted
- Post Translation Modifications
- Glycosylation at Ser43, Thr46, Asn69, and Asn114
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 5 sites, 1 O-linked glycan (3 sites)
- Protein Refseq
- XP_006710726.1; XP_011539820.1; XP_054192764.1; XP_054192765.1; NP_002497.2
- Function
- Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-111 | Anti-Human NGF Recombinant Antibody (TAB-111) | ELISA, FuncS, Inhib | IgG2 |
| TAB-686CL | Anti-Human NGF Therapeutical Antibody (TAB-686CL) | FuncS | Antibody |
| TAB-501MZ | Anti-Human NGF Recombinant Antibody (TAB-501MZ) | ELISA | Humanized antibody |
| TAB-501MZ-S(P) | Anti-Human NGF Recombinant Antibody scFv Fragment (TAB-501MZ-S(P)) | ELISA, IRMA, RIA, IHC | Humanized antibody |
| TAB-501MZ-F(E) | Anti-Human NGF Recombinant Antibody Fab Fragment (TAB-501MZ-F(E)) | ELISA, IRMA, RIA, IHC | Humanized antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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