Human Anti-NGF scFv-Fc Chimera (VS-0425-FY156)
CAT#: VS-0425-FY156
The anti-NGF (nerve growth factor) scFv-FC is a recombinant construct that features a single-chain variable fragment specific to NGF fused to the FC region. NGF is vital for the growth, maintenance, and survival of certain neurons and has been implicated in pain signaling. This scFv-FC has potential applications in pain management and neurodegenerative diseases, as it can modulate NGF activity, providing a targeted approach to treating conditions like chronic pain and neuropathy.

Specifications
- Immunogen
- Human NGF as an immunogen.
- Host Species
- Human
- Type
- Human IgG2, scFv-Fc
- Specificity
- Human NGF
- Species Reactivity
- Human
- Applications
- Neutralization, ELISA
- Related Disease
- Bone cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Nerve Growth Factor; Nerve Growth Factor (Beta Polypeptide); Beta-NGF; NGFB; Nerve Growth Factor, Beta Subunit; Beta-Nerve Growth Factor; HSAN5
- Gene ID
- 4803
- UniProt ID
- P01138
- Long Name
- Nerve Growth Factor
- Sequence Similarities
- Belongs to the NGF-beta family.
- Cellular Localization
- Endosome, Secreted
- Post Translation Modifications
- Glycosylation at Ser43, Thr46, Asn69, and Asn114
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 5 sites, 1 O-linked glycan (3 sites)
- Protein Refseq
- XP_006710726.1; XP_011539820.1; XP_054192764.1; XP_054192765.1; NP_002497.2
- Function
- Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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TAB-510MZ-S(P) | Mouse Anti-NGF Recombinant Antibody; scFv Fragment (TAB-510MZ-S(P)) | ELISA | Mouse scFv |
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TAB-510MZ-F(E) | Human Anti-NGF Recombinant Antibody; Fab Fragment (TAB-510MZ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
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