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    Recombinant Human Anti-NY-ESO-1 Soluble TCR (ZIP-Fos/ZIP-Jun) (VS-0622-YF41) (CAT#: VS-0622-YF41)

    Human TCR recognizes NY-ESO-1 peptide (SRLLEFYLAMPFATP) in the context of HLA-DRB5*0202. Soluble TCR expressed with ZIP-Fos/ZIP-Jun strategy (TRAV-TRAC partial-ZIP-Fos, TRBV-TRBC partial-ZIP-Jun) was validated to be able to bind pMHC in published references. The same expression strategy (ZIP-Fos/ZIP-Jun) is used to express this recombinant Human soluble TCR. Please note that the activity is not guaranteed.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 High expression in testis.
    Figure 1 High expression in testis.

    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13061/ihc_selected.jpg
    Figure 2 Low expression in endometrium 1.
    Figure 2 Low expression in endometrium 1.

    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13061/32112_B_4_3_val_selected.jpg
    Figure 3 Testis
    Figure 3 Testis
    (Pachytene spermatocytes Staining: High Intensity: Strong Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/13061/32112_A_6_6.jpg
    RNA Expression
    Figure 4 RNA cell line category: Group enriched (U-266/70, U-266/84)
    Figure 4 RNA cell line category: Group enriched (U-266/70, U-266/84)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000268651-CTAG1A

    Specifications

    • Host Species
    • Human
    • Target
    • NY-ESO-1
    • Species Reactivity
    • Human
    • Epitope
    • SRLLEFYLAMPFATP
    • MHC
    • HLA-DRB5*0202
    • Type
    • Soluble TCR (ZIP-Fos/ZIP-Jun)
    • Related Disease
    • Melanoma, breast cancer, lung cancer, prostate cancer, thyroid cancer, ovarian cancer, or synovial cell sarcoma.
    • TCR Expression Strategy
    • ZIP-Fos/ZIP-Jun strategy: the alpha and beta chain (without transmembrane and cytosolic region) can form heterodimer based on ZIP-Fox/ZIP-Jun. The soluble TCR contains variable regions and partial constant regions.

    Target

    • Alternative Names
    • CTAG1A; CT6.1; CTAG; Cancer/Testis Antigen 6.1; Cancer/Testis Antigen 1; Autoimmunogenic Cancer/Testis Antigen NY-ESO-1; CTAG1; LAGE2A

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