Human Anti-PTK7 scFv-Fc Chimera (VS-0425-FY170)
CAT#: VS-0425-FY170
Anti-PTK7 scFv-FC is a specialized therapeutic protein designed to target and inhibit the function of the protein PTK7 (Protein Tyrosine Kinase 7), which plays a role in various cellular processes, including cell signaling and migration, and is implicated in several cancers.
Specifications
- Immunogen
- PTK7 extracellular domain (ECD) as an immunogen.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human PTK7
- Species Reactivity
- Human
- Applications
- Western Blot, ELISA, Immunohistochemistry
- Related Disease
- Panic Disorder and Anxiety
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Protein Tyrosine Kinase 7 (Inactive); CCK4; Colon Carcinoma Kinase 4; Inactive Tyrosine-Protein Kinase 7; Pseudo Tyrosine Kinase Receptor 7
- Gene ID
- 5754
- UniProt ID
- Q13308
- Long Name
- Protein Tyrosine Kinase 7 (Inactive)
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
- Cellular Localization
- Cell junction, Membrane
- Post Translation Modifications
- MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment.
Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.
Glycosylation at Asn116, Asn175, Asn184, Asn214, Asn268, Asn283, Asn405, Asn567, Asn463, and Asn646
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect PTK7_HUMAN (655)
Glycosylation from GlyGen 13 sites, 75 N-linked glycans (9 sites), 2 O-linked glycans (3 sites)
- Protein Refseq
- XP_011513067.1; XP_011513068.1; XP_047275113.1; XP_054212039.1; XP_054212040.1
- Function
- Inactive tyrosine kinase involved in Wnt signaling pathway.
Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway.
Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis.
Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0356CT | Recombinant Mouse anti-Human PTK7 Monoclonal antibody (EML650) | WB | |
| HPAB-0027-LS | Human Anti-PTK7 Recombinant Antibody (HPAB-0027-LS) | ELISA, IB, FC, FuncS | Humanized IgG4 κ |
| ZG-0368F | Mouse Anti-PTK7 Recombinant Antibody (ZG-0368F) | WB, IHC, ELISA | Mouse IgG |
| VS3-XY1318 | Mouse Anti-PTK7 Recombinant Antibody (clone 4F9) | ELISA, WB, IHC | Mouse IgG1 |
| VS7-0425-WR716 | Mouse Anti-PTK7 Monoclonal Antibody (VS7-0425-WR716) | WB, IHC-P, IF, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0027-LS-F(E) | Human Anti-PTK7 Recombinant Antibody; Fab Fragment (HPAB-0027-LS-F(E)) | ELISA | Humanized Fab |
| HPAB-0028-LS-F(E) | Human Anti-PTK7 Recombinant Antibody; Fab Fragment (HPAB-0028-LS-F(E)) | ELISA, FC | Human Fab |
| HPAB-0029-LS-F(E) | Human Anti-PTK7 Recombinant Antibody; Fab Fragment (HPAB-0029-LS-F(E)) | ELISA, FC | Human Fab |
| HPAB-0030-LS-F(E) | Human Anti-PTK7 Recombinant Antibody; Fab Fragment (HPAB-0030-LS-F(E)) | ELISA, FC | Human Fab |
| HPAB-0031-LS-F(E) | Human Anti-PTK7 Recombinant Antibody; Fab Fragment (HPAB-0031-LS-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0027-LS-S(P) | Human Anti-PTK7 Recombinant Antibody; scFv Fragment (HPAB-0027-LS-S(P)) | ELISA | Humanized scFv |
| HPAB-0028-LS-S(P) | Human Anti-PTK7 Recombinant Antibody; scFv Fragment (HPAB-0028-LS-S(P)) | ELISA, FC | Human scFv |
| HPAB-0029-LS-S(P) | Human Anti-PTK7 Recombinant Antibody; scFv Fragment (HPAB-0029-LS-S(P)) | ELISA, FC | Human scFv |
| HPAB-0030-LS-S(P) | Human Anti-PTK7 Recombinant Antibody; scFv Fragment (HPAB-0030-LS-S(P)) | ELISA, FC | Human scFv |
| HPAB-0031-LS-S(P) | Human Anti-PTK7 Recombinant Antibody; scFv Fragment (HPAB-0031-LS-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC670 | Recombinant Anti-PTK7 Vesicular Antibody, EV Displayed (VS-0425-YC670) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY5851 | Anti-PTK7 Immunohistochemistry Kit | IHC | |
| VS-0525-XY5852 | Anti-Rat PTK7 Immunohistochemistry Kit | IHC |
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