Human Anti-PTK7 scFv-Fc Chimera (VS-0425-FY170) (CAT#: VS-0425-FY170)

• Immunogen
• PTK7 extracellular domain (ECD) as an immunogen.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human PTK7

• Species Reactivity
• Human

• Applications
• Western Blot, ELISA, Immunohistochemistry

• Related Disease
• Panic Disorder and Anxiety

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Protein Tyrosine Kinase 7 (Inactive); CCK4; Colon Carcinoma Kinase 4; Inactive Tyrosine-Protein Kinase 7; Pseudo Tyrosine Kinase Receptor 7

• Gene ID
• 5754

• UniProt ID
• Q13308

• Long Name
• Protein Tyrosine Kinase 7 (Inactive)

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

• Cellular Localization
• Cell junction, Membrane

• Post Translation Modifications
• MMP14 cleaves PTK7 between Pro-621 and Leu-622 generating an N-terminal soluble (70 kDa) fragment and a membrane C-terminal (50 kDa) fragment.
  Proteolysis by MMP14 regulates PTK7 function in non-canonical Wnt signaling pathway.
  Glycosylation at Asn116, Asn175, Asn184, Asn214, Asn268, Asn283, Asn405, Asn567, Asn463, and Asn646
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect PTK7_HUMAN (655)
  Glycosylation from GlyGen 13 sites, 75 N-linked glycans (9 sites), 2 O-linked glycans (3 sites)

• Protein Refseq
• XP_011513067.1; XP_011513068.1; XP_047275113.1; XP_054212039.1; XP_054212040.1

• Function
• Inactive tyrosine kinase involved in Wnt signaling pathway.
  Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway.
  Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis.
  Has a role in embryogenesis, epithelial tissue organization and angiogenesis.

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