Human Anti-SELL scFv-Fc Chimera (VS-0425-FY146)
CAT#: VS-0425-FY146
The anti-SELL scFv-FC is a recombinant antibody targeting L-selectin (SELL), a cell adhesion molecule involved in leukocyte trafficking during immune responses. By binding to SELL, this scFv-FC could potentially modulate inflammation and immune cell recruitment, offering therapeutic benefits in conditions with dysregulated immune responses. The Fc domain enhances the antibody's stability and interaction with effector cells.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line REH
Immunofluorescent staining of human cell line REH shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51972/1676_B10_3_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51972/1704_H2_7_cr57d82833dfda8_blue_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51972/1674_B10_31_blue_red_green.jpg
Normal Tissue
Figure 4 Appendix
Lymphoid tissue
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2144/5974_A_3_2.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2144/5974_A_8_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Daudi, JURKAT, MOLT-4, U-266/70, U-698, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000188404-SELL
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Specifications
- Immunogen
- Human SELL as an immunogen.
- Host Species
- Human
- Type
- Human IgG4, scFv-Fc
- Specificity
- Human SELL
- Species Reactivity
- Human
- Applications
- Flow Cytometry, Immunoprecipitation, ELISA, Neutralization, Immunofluorescence, Western Blot
- Related Disease
- Immunoglobulin A nephropathy
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Selectin L; Leukocyte-Endothelial Cell Adhesion Molecule 1; CD62 Antigen-Like Family Member L; Leukocyte Surface Antigen Leu-8; Lymphocyte Adhesion Molecule 1; Lymph Node Homing Receptor; Gp90-MEL; LECAM1; LYAM1; LNHR; TQ1
- Gene ID
- 6402
- UniProt ID
- P14151
- Long Name
- Selectin L
- Sequence Similarities
- Belongs to the selectin/LECAM family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- N-glycosylated.
Glycosylation at Asn60, Asn104, Asn177, Asn232, Asn246, and Asn271
Ubiquitination at Lys78, Lys93, Lys134, Lys137, and Lys141
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect LYAM1_HUMAN (346)
Glycosylation from GlyGen 7 sites, 52 N-linked glycans (2 sites)
- Protein Refseq
- NP_000646.3
- Function
- Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells.
Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes.
Promotes initial tethering and rolling of leukocytes in endothelia.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
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| TAB-0710CL | Human Anti-SELL Recombinant Antibody (TAB-0710CL) | ELISA | Humanized antibody |
| TAB-0710CL-S(P) | Human Anti-SELL Recombinant Antibody; scFv Fragment (TAB-0710CL-S(P)) | ELISA | Humanized scFv |
| TAB-0710CL-F(E) | Human Anti-SELL Recombinant Antibody; Fab Fragment (TAB-0710CL-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1931CQ | Recombinant Mouse Anti-SELL Antibody (DREG-56) | FC, WB, BL | IgG1, κ |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4409 | Hi-Affi™ Recombinant Rabbit Anti-SELL Monoclonal Antibody (SI501DS) | FC | IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0104-LS-F(E) | Human Anti-SELL Recombinant Antibody; Fab Fragment (HPAB-0104-LS-F(E)) | ELISA | Human Fab |
| FAMAB-0208-YC-F(E) | Mouse Anti-SELL Recombinant Antibody (clone DREG-55); Fab Fragment | FC, FuncS | Mouse Fab |
| FAMAB-0209-YC-F(E) | Mouse Anti-SELL Recombinant Antibody (clone DREG-200); Fab Fragment | FC, FuncS | Mouse Fab |
| FAMAB-0210-YC-F(E) | Human Anti-SELL Recombinant Antibody (clone HuDREG-55); Fab Fragment | FC, FuncS | Humanized Fab |
| FAMAB-0211-YC-F(E) | Human Anti-SELL Recombinant Antibody (clone HuDREG-200); Fab Fragment | FC, FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0208YC | Mouse Anti-SELL Recombinant Antibody (clone DREG-55) | FC, FuncS | Mouse IgG |
| FAMAB-0209YC | Mouse Anti-SELL Recombinant Antibody (clone DREG-200) | FC, FuncS | Mouse IgG |
| FAMAB-0210YC | Human Anti-SELL Recombinant Antibody (clone HuDREG-55) | FC, FuncS | Humanized IgG4 |
| FAMAB-0211YC | Human Anti-SELL Recombinant Antibody (clone HuDREG-200) | FC, FuncS | Humanized IgG4 |
| ZG-0698F | Mouse Anti-SELL Recombinant Antibody (clone 1H3) | FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-720 | Afuco™ Anti-SELL ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-720) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY106 | Mouse Anti-NHP SELL Recombinant Antibody (clone FMC46) | FC | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6435 | Anti-SELL Immunohistochemistry Kit | IHC | |
| VS-0525-XY6436 | Anti-Mouse SELL Immunohistochemistry Kit | IHC |
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