Human Anti-SLITRK6 (clone Sirtratumab) scFv-Fc Chimera
CAT#: VS-0425-FY184
The anti-SLITRK6 scFv-FC is a monoclonal antibody designed to target the SLITRK6 protein. The scFv-FC format combines a single-chain variable fragment (scFv) that specifically binds to SLITRK6 with the human Fc domain, enhancing its stability, half-life, and potential for therapeutic applications. This antibody can be used for research, diagnostic, and therapeutic purposes, particularly in the fields of neuroscience and neurology.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14513/1641_H1_3_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows moderate cytoplasmic and membranous positivity in urothelial cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14491/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14513/1601_E2_2_blue_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14491/62736_B_9_5.jpg
Normal Tissue
Figure 5 Salivary gland
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14491/62736_B_1_1.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14491/62736_A_7_3.jpg
Normal Tissue
Figure 7 Liver
Cholangiocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14491/62736_A_8_4.jpg
Normal Tissue
Figure 8 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14491/62736_A_7_5.jpg
Normal Tissue
Figure 9 Testis
Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14491/62736_A_6_6.jpg
RNA Expression
Figure 10 RNA cell line category: Cell line enhanced (hTCEpi, OE19, RT4, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000184564-SLITRK6
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Specifications
- Immunogen
- Human SLITRK6 as an immunogen.
- Host Species
- Human
- Type
- Human IgG2, scFv-Fc
- Specificity
- Human SLITRK6
- Species Reactivity
- Human
- Clone
- Sirtratumab
- Applications
- ELISA
- Related Disease
- Deafness And Myopia and Rare Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- SLIT And NTRK Like Family Member 6; SLIT And NTRK-Like Family, Member 6; SLIT And NTRK-Like Protein 6; Slit And Trk Like Gene 6; 4832410J21Rik; DFNMYP
- Gene ID
- 84189
- UniProt ID
- Q9H5Y7
- Long Name
- SLIT And NTRK Like Family Member 6
- Sequence Similarities
- Belongs to the SLITRK family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Thr318 and Thr322
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 4 sites, 1 O-linked glycan (3 sites)
- Protein Refseq
- NP_115605.2
- Function
- Regulator of neurite outgrowth required for normal hearing and vision.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone Sirtratumab"
- CAT
- Product Name
See other products for "SLITRK6"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0923-FY258 | Recombinant Human Anti-SLITRK6 Antibody (clone Sirtratumab) | ELISA, WB | Human IgG2, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC3 | Recombinant Anti-SLITRK6 Vesicular Antibody, EV Displayed (VS-0425-YC3) | ELISA, FC, Cell-uptake |
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