Human Anti-SMAD2 scFv-Fc Chimera (VS-0125-FY71) (CAT#: VS-0125-FY71)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Species Reactivity
• Human

• Applications
• Antibody-dependent cellular cytotoxicity

• Purity
• >95% as determined by SDS-PAGE

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS

• Preservative
• No preservatives

• Stabilizer
• No Stabilizers

• Sterility
• 0.2 μM filtered

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The antibody-single chain variable fragment Fc (scFv-Fc) achieves targeted specificity through its scFv component, which can recognize and bind to specific antigens. By incorporating the Fc region, the scFv-Fc's stability and half-life are enhanced, extending its circulation time in the body. The presence of the Fc region also imparts the ability to modulate immune responses, such as activating the complement system and promoting antibody-dependent cell-mediated cytotoxicity (ADCC). Therefore, scFv-Fc is widely applied in the biomedical field, particularly in targeted therapy, vaccine development, and diagnostic reagents.

• Alternative Names
• SMAD Family Member 2; MAD Homolog 2; HSMAD2; JV18-1; HMAD-2; MADH2; MADR2; MAD, Mothers Against Decapentaplegic Homolog 2 (Drosophila); SMAD, Mothers Against DPP Homolog 2 (Drosophila); Mothers Against Decapentaplegic Homolog 2

• Gene ID
• 4087

• UniProt ID
• Q15796

• Sequence Similarities
• Belongs to the dwarfin/SMAD family.

• Cellular Localization
• Cytoplasm
  Nucleus

• Post Translation Modifications
• Phosphorylated on one or several of Thr-220, Ser-245, Ser-250, and Ser-255.
  In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2.
  Phosphorylated by MAPK3 upon EGF stimulation; which increases transcriptional activity and stability, and is blocked by calmodulin.
  Phosphorylated by PDPK1.
  In response to TGF-beta, ubiquitinated by NEDD4L; which promotes its degradation.
  Acetylated on Lys-19 by coactivators in response to TGF-beta signaling, which increases transcriptional activity.
  Modification sites at PhosphoSitePlus
  Modification sites at neXtProt
  Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• XP_016881238.1; XP_047293463.1; XP_047293464.1; XP_054174595.1; XP_054174596.1

• Function
• Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases.
  Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription.

Secondary Antibody

• 2ND-029CQ
• Goat Anti-Human IgG Fc Antibody

Isotype Control

• MOB-200CQ
• Human IgG Fc Isotype Control Antibody

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