Human Anti-SNCA scFv-Fc Chimera (VS-0325-FY32)
CAT#: VS-0325-FY32
The anti-SNCA scFv-Fc antibody targets alpha-synuclein (SNCA), a protein implicated in Parkinson's disease and other neurodegenerative disorders. It is useful for studying the role of SNCA in protein aggregation, neuronal dysfunction, and disease progression.
Gene Expression
Normal Tissue
Figure 1 High expression in cerebral cortex
Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_9_5.jpg
Normal Tissue
Figure 2 Colon
Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10877/164900_A_7_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_7_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164893_A_6_6.jpg
Normal Tissue
Figure 5 Bone marrow
Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5459/164874_B_4_4.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (HEL, HUVEC TERT2, RT4, SK-MEL-30, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145335-SNCA
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Specifications
- Immunogen
- α-Syn aggregates with cleaved C-terminal 21 residues as antigens.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- It recognizes specific sequence of alpha-synuclein and do not recognize the common structure of the aggregates derived from alpha-synuclein, amyloid beta, and tau. It specifically binds only to alpha-synuclein-derived aggregates and not to amyloid beta1-42 and tau-derived aggregates.
- Species Reactivity
- Human
- Applications
- ELISA, Inhibition
- Related Disease
- Neurodegenerative disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Synuclein Alpha; Synuclein, Alpha (Non A4 Component Of Amyloid Precursor); Alpha-Synuclein; PARK1; NACP; Parkinson Disease (Autosomal Dominant, Lewy Body) 4; Non A4 Component Of Amyloid Precursor; Non-A4 Component Of Amyloid Precursor
- Gene ID
- 6622
- UniProt ID
- P37840
- Long Name
- Synuclein Alpha
- Sequence Similarities
- Belongs to the synuclein family.
- Cellular Localization
- Cytoplasm; Membrane; Nucleus; Synapse; Secreted; Cell projection
- Post Translation Modifications
- Phosphorylated, predominantly on serine residues. Phosphorylation by CK1 appears to occur on residues distinct from the residue phosphorylated by other kinases. Phosphorylation of Ser-129 is selective and extensive in synucleinopathy lesions. In vitro, phosphorylation at Ser-129 promoted insoluble fibril formation. Phosphorylated on Tyr-125 by a PTK2B-dependent pathway upon osmotic stress.
Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine residues and possibly by dityrosine cross-linking to generated stable oligomers.
Ubiquitinated. The predominant conjugate is the diubiquitinated form.
Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.
- Protein Refseq
- NP_000336.1; NP_001139526.1; NP_001139527.1
- Function
- Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (PubMed:28288128, PubMed:30404828, PubMed:20798282, PubMed:26442590).
Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828).
Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828).
Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282).
This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282).
Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "SNCA"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1365z | Mouse Anti-SNCA Recombinant Antibody (clone 8F8) | ELISA, FC, ICC, IF, WB | Mouse IgG1 |
| MOB-0599MZ | Recombinant Mouse Anti-Human SNCA Antibody (clone 20D4) | ELISA, WB | Mouse antibody |
| HPAB-653-FY | Mouse Anti-SNCA Recombinant Antibody (HPAB-653-FY) | ELISA, IP | Mouse IgG |
| HPAB-654-FY | Mouse Anti-SNCA Recombinant Antibody (HPAB-654-FY) | ELISA | Mouse IgG |
| VS3-FY1367 | Recombinant Rabbit Anti-SNCA Antibody (clone R01-4E1) | WB, IHC-P, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B031(A) | Recombinant Anti-human SNCA Intrabody [(D-Arg)9] | FC, IF, FuncS | scFv-(D-Arg)9 |
| IAB-B031(G) | Recombinant Anti-human SNCA Intrabody [+36 GFP] | CO-IP, FuncS | scFv-(+36GFP) |
| IAB-B031(T) | Recombinant Anti-human SNCA Intrabody [Tat] | ELISA, IF, Neut, FuncS | scFv-Tat |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PNBL-086 | Recombinant Anti-SNCA VHH Single Domain Antibody (PNBL-086) | WB, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0740CLV | Rabbit Anti-SNCA Recombinant Antibody (TAB-0740CLV) | ELISA | Chimeric antibody (mouse/rabbit) |
| TAB-0740CLV-F(E) | Rabbit Anti-SNCA Recombinant Antibody; Fab Fragment (TAB-0740CLV-F(E)) | ELISA | Chimeric antibody (mouse/rabbit) |
| TAB-0740CLV-S(P) | Rabbit Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0740CLV-S(P)) | ELISA | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0741CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0741CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0742CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0742CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0743CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0743CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0744CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0744CLV-S(P)) | ELISA | Mouse scFv |
| TAB-0745CLV-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (TAB-0745CLV-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1977CQ | Recombinant Human Anti-SNCA Antibody (NAC32) | IHC, WB, BL | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0154 | Hi-Affi™ Recombinant Rabbit Anti-alpha + beta Synuclein Monoclonal Antibody (DS154AB) | FC, WB, ICC, IF | IgG |
| MOR-3354 | Hi-Affi™ Recombinant Rabbit Anti-SNCA Monoclonal Antibody (DS3354AB) | IHC, ICC, FC, IP | IgG |
| MOR-4530 | Hi-Affi™ Recombinant Rabbit Anti-SNCA Monoclonal Antibody (TH38DS) | WB, IF, ICC, IHC-P, FC | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-005CN | Mouse Anti-SNCA Recombinant Antibody (NS-005CN) | WB, ELISA, FC | Mouse IgG2a |
| NS-088CN | Mouse Anti-SNCA Recombinant Antibody (NS-088CN) | WB, ELISA, IHC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0260-CN-F(E) | Human Anti-SNCA Recombinant Antibody (clone D10); Fab Fragment | ELISA | Human Fab |
| FAMAB-0261-CN-F(E) | Human Anti-SNCA Recombinant Antibody (clone 6E); Fab Fragment | ELISA | Human Fab |
| HPAB-0023-FY-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-0023-FY-F(E)) | ELISA | Mouse Fab |
| HPAB-653-FY-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-653-FY-F(E)) | WB, IP, ELISA | Mouse Fab |
| HPAB-M0696-YC-F(E) | Mouse Anti-SNCA Recombinant Antibody; Fab Fragment (HPAB-M0696-YC-F(E)) | ELISA, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0023-FY-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (HPAB-0023-FY-S(P)) | ELISA | Mouse scFv |
| HPAB-N0389-YC-S(P) | Human Anti-SNCA Recombinant Antibody; scFv Fragment (HPAB-N0389-YC-S(P)) | ELISA, IP, FuncS | Human scFv |
| HPAB-N0390-YC-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (HPAB-N0390-YC-S(P)) | ELISA, IP, FuncS | Mouse scFv |
| HPAB-M0696-YC-S(P) | Mouse Anti-SNCA Recombinant Antibody; scFv Fragment (HPAB-M0696-YC-S(P)) | ELISA, FuncS | Mouse scFv |
| HPAB-0753-WJ-S(P) | Human Anti-SNCA Recombinant Antibody; scFv Fragment (HPAB-0753-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY244 | AbPlus™ Anti-SNCA Magnetic Beads (JB42-33) | IP, Protein Purification | |
| VS-0724-YC791 | AbPlus™ Anti-SNCA Magnetic Beads (VS-0724-YC791) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2129 | Anti-SNCA Immunohistochemistry Kit | IHC | |
| VS-0525-XY6773 | Anti-Mouse SNCA Immunohistochemistry Kit | IHC | |
| VS-0525-XY6772 | Anti-Human SNCA Immunohistochemistry Kit | IHC | |
| VS-0525-XY6774 | Anti-Rat SNCA Immunohistochemistry Kit | IHC |
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