Human Anti-SOST scFv-Fc Chimera (VS-0425-FY180)
CAT#: VS-0425-FY180
The anti-SOST scFv-FC is a monoclonal antibody designed to target the sclerostin (SOST) protein. Sclerostin is a protein that plays a role in bone metabolism and is involved in the regulation of bone formation and resorption. The scFv-FC format of this antibody combines a single-chain variable fragment (scFv) that specifically binds to SOST with the human Fc domain, enhancing its stability, half-life, and potential for therapeutic applications. This antibody can be used for research, diagnostic, and therapeutic purposes, particularly in the fields of bone biology and osteoporosis.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Group enriched (HaCaT, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000167941-SOST
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Specifications
- Immunogen
- Human SOST as an immunogen.
- Host Species
- Human
- Type
- Human IgG2, scFv-Fc
- Specificity
- Human SOST
- Species Reactivity
- Human
- Applications
- Inhibition, ELISA
- Related Disease
- Van Buchem disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 1/5000-1/10000
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Sclerostin; Sclerosteosis; DAND6; SOST1; VBCH; CDD
- Gene ID
- 50964
- UniProt ID
- Q9BQB4
- Long Name
- Sclerostin
- Sequence Similarities
- Belongs to the sclerostin family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn53 and Asn175
Glycosylation from GlyGen 2 sites
- Protein Refseq
- NP_079513.1
- Function
- Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "SOST"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-580CL | Human Anti-SOST Recombinant Antibody (TAB-580CL) | ELISA, WB | Human IgG |
| TAB-411CT | Humanized Anti-SOST Recombinant Antibody (TAB-411CT) | ELISA, Neut | Humanized antibody |
| TAB-411CT-F(E) | Humanized Anti-SOST Recombinant Antibody; Fab Fragment (TAB-411CT-F(E)) | ELISA, Neut | Humanized Fab |
| TAB-412CT-F(E) | Humanized Anti-SOST Recombinant Antibody; Fab Fragment (TAB-412CT-F(E)) | ELISA, Neut | Humanized Fab |
| TAB-413CT-F(E) | Humanized Anti-SOST Recombinant Antibody; Fab Fragment (TAB-413CT-F(E)) | ELISA, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-558CL | Afuco™ Anti-SOST Recombinant Antibody (AFC-558CL), ADCC Enhanced | ELISA, WB | Humanized IgG1 |
| AFC-TAB-116 | Afuco™ Anti-SOST Recombinant Antibody (AFC-TAB-116), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | Human IgG1, κ |
| AFC-TAB-115 | Afuco™ Anti-SOST ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-115) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-384CT | Llama Anti-SOST Recombinant Antibody (TAB-384CT) | WB, ELSA, FC | Llama VHH |
| TAB-385CT | Anti-Human SOST Single Domain Antibody (TAB-385CT), Research Grade Biosimilar | WB, ELSA, FC | Single domain antibody |
| TAB-386CT | Anti-Human SOST Single Domain Antibody (TAB-386CT), Research Grade Biosimilar | WB, ELSA, FC | Single domain antibody |
| TAB-387CT | Anti-Human SOST Single Domain Antibody (TAB-387CT), Research Grade Biosimilar | WB, ELSA, FC | Single domain antibody |
| TAB-388CT | Anti-Human SOST Single Domain Antibody (TAB-388CT), Research Grade Biosimilar | WB, ELSA, FC | Single domain antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-393CT-F(E) | Anti-Human SOST Recombinant Antibody Fab Fragment (DM4) | ELISA, Neut | Human antibody |
| TAB-394CT-F(E) | Human Anti-SOST Recombinant Antibody; Fab Fragment (TAB-394CT-F(E)) | ELISA, Neut | Human Fab |
| TAB-395CT-F(E) | Human Anti-SOST Recombinant Antibody; Fab Fragment (TAB-395CT-F(E)) | ELISA, Neut | Human Fab |
| TAB-396CT-F(E) | Human Anti-SOST Recombinant Antibody; Fab Fragment (TAB-396CT-F(E)) | ELISA, Neut | Human Fab |
| TAB-397CT-F(E) | Human Anti-SOST Recombinant Antibody; Fab Fragment (TAB-397CT-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4434 | Hi-Affi™ Recombinant Rabbit Anti-SOST Monoclonal Antibody (SI527DS) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0342-YC-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-0342-YC-S(P)) | Neut, FuncS | Humanized scFv |
| HPAB-0343-YC-S(P) | Mouse Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-0343-YC-S(P)) | FuncS | Mouse scFv |
| HPAB-0344-YC-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-0344-YC-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-0461-CN-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-0461-CN-S(P)) | ELISA, Block | Human scFv |
| PSBC-402 | Human Anti-SOST Recombinant Antibody; scFv Fragment (PSBC-402) | IHC, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-012LC | Mouse Anti-SOST Recombinant Antibody (MOB-012LC) | ELISA | Mouse IgG |
| HPAB-1122LY | Human Anti-SOST Recombinant Antibody (HPAB-1122LY) | ELISA | Humanized IgG |
| HPAB-1123LY | Human Anti-SOST Recombinant Antibody (HPAB-1123LY) | ELISA, Block | Humanized IgG |
| HPAB-0920-WJ | Human Anti-SOST Recombinant Antibody (HPAB-0920-WJ) | ELISA | Humanized IgG |
| HPAB-0921-WJ | Human Anti-SOST Recombinant Antibody (HPAB-0921-WJ) | ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0579-WJ-F(E) | Human Anti-SOST Recombinant Antibody; Fab Fragment (HPAB-0579-WJ-F(E)) | ELISA | Human Fab |
| HPAB-1421-FY-S(P) | Rat Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-1421-FY-S(P)) | ELISA | Chimeric (mouse/rat) scFv |
| HPAB-1422-FY-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-1422-FY-S(P)) | ELISA | Humanized scFv |
| HPAB-1423-FY-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-1423-FY-S(P)) | ELISA | Humanized scFv |
| HPAB-1424-FY-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-1424-FY-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY246 | AbPlus™ Anti-SOST Magnetic Beads (VS-0424-XY2446) | IP, Protein Purification |
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