Human Anti-SOST scFv-Fc Chimera (VS-0425-FY180) (CAT#: VS-0425-FY180)
The anti-SOST scFv-FC is a monoclonal antibody designed to target the sclerostin (SOST) protein. Sclerostin is a protein that plays a role in bone metabolism and is involved in the regulation of bone formation and resorption. The scFv-FC format of this antibody combines a single-chain variable fragment (scFv) that specifically binds to SOST with the human Fc domain, enhancing its stability, half-life, and potential for therapeutic applications. This antibody can be used for research, diagnostic, and therapeutic purposes, particularly in the fields of bone biology and osteoporosis.
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RNA Expression
Figure 1 RNA cell line category: Group enriched (HaCaT, SuSa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000167941-SOST
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000167941-SOST
Specifications
- Immunogen
- Human SOST as an immunogen.
- Host Species
- Human
- Type
- Human IgG2, scFv-Fc
- Specificity
- Human SOST
- Species Reactivity
- Human
- Applications
- Inhibition, ELISA
- Related Disease
- Van Buchem disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 1/5000-1/10000
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Sclerostin; Sclerosteosis; DAND6; SOST1; VBCH; CDD
- Gene ID
- 50964
- UniProt ID
- Q9BQB4
- Long Name
- Sclerostin
- Sequence Similarities
- Belongs to the sclerostin family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn53 and Asn175
Glycosylation from GlyGen 2 sites
- Protein Refseq
- NP_079513.1
- Function
- Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2432z | Mouse Anti-SOST Recombinant Antibody (clone 44A4) | WB, ELISA | Mouse IgG2b |
| HPAB-1122LY | Human Anti-SOST Recombinant Antibody (HPAB-1122LY) | ELISA | Humanized IgG |
| HPAB-1123LY | Human Anti-SOST Recombinant Antibody (HPAB-1123LY) | ELISA, Block | Humanized IgG |
| PABC-402 | Human Anti-SOST Recombinant Antibody (PABC-402) | SPR, ELISA, IHC, Neut | Human IgG1 |
| HPAB-1128-CN | Human Anti-SOST Recombinant Antibody (clone Ab1) | WB, ELISA | Human IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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