Human Anti-TAG72 (clone hum4) scFv-Fc Chimera (CAT#: VS-0125-FY87)
Anti-TAG-72 scFv-Fc is an antibody constructed by fusing a single-chain variable fragment (scFv) with an Fc fragment, specifically targeting tumor-associated glycoprotein 72 (TAG-72). TAG-72 is a tumor marker that is highly expressed in various cancers, particularly in solid tumors such as breast cancer and colon cancer. By targeting TAG-72, anti-TAG-72 scFv-Fc has the potential to serve as an effective cancer therapeutic strategy.
Specific Inquiry
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- hum4
- Applications
- ELISA, Inhibition, Surface Plasmon Resonance, Antibody-dependent cellular cytotoxicity
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The single-chain antibody fragment (scFv), comprising the variable regions from both the light and heavy chains of antibodies, has the potential to selectively bind to target antigens such as TAG-72. In contrast, the Fc fragment, consisting of the antibody's constant region, offers enhanced stability and prolongs the antibody's half-life in the bloodstream. Additionally, the Fc fragment's capability to engage with cell surface Fcγ receptors may allow for the modulation of various antibody functions, including the potential promotion of antibody-dependent cellular cytotoxicity (ADCC).
Target
- Alternative Names
- TAG-72, Cancer Antigen 72-4 (CA 72-4), MUC1
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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ADCC Enhanced Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-723 | Mouse Anti-TAG72 Recombinant Antibody (clone Anatumomab); Fab Fragment | FuncS, IF, Neut, ELISA, FC, IP, WB | Mouse Fab (IgG1, κ) |
| TAB-H60 | Anti-Human TAG-72 Recombinant Antibody (Satumomab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
| TAB-249 | Anti-Human TAG-72 Recombinant Antibody (Minretumomab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 |
| TAB-002 | Anti-Human TAG72 Recombinant Antibody (Satumomab Pendetide) | IP, IF, FuncS, FC, Neut, ELISA, WB | IgG1 |
| PABX-025-S (P) | Recombinant Human Anti-TAG-72 Antibody scFv Fragment (PABX-025-S (P)) | WB, Neut, FuncS | scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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