Human Anti-TAG72 (clone hum4) scFv-Fc Chimera
CAT#: VS-0125-FY87
Anti-TAG-72 scFv-Fc is an antibody constructed by fusing a single-chain variable fragment (scFv) with an Fc fragment, specifically targeting tumor-associated glycoprotein 72 (TAG-72). TAG-72 is a tumor marker that is highly expressed in various cancers, particularly in solid tumors such as breast cancer and colon cancer. By targeting TAG-72, anti-TAG-72 scFv-Fc has the potential to serve as an effective cancer therapeutic strategy.
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- hum4
- Applications
- ELISA, Inhibition, Surface Plasmon Resonance, Antibody-dependent cellular cytotoxicity
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The single-chain antibody fragment (scFv), comprising the variable regions from both the light and heavy chains of antibodies, has the potential to selectively bind to target antigens such as TAG-72. In contrast, the Fc fragment, consisting of the antibody's constant region, offers enhanced stability and prolongs the antibody's half-life in the bloodstream. Additionally, the Fc fragment's capability to engage with cell surface Fcγ receptors may allow for the modulation of various antibody functions, including the potential promotion of antibody-dependent cellular cytotoxicity (ADCC).
Target
- Alternative Names
- TAG-72, Cancer Antigen 72-4 (CA 72-4), MUC1
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "Clone hum4"
- CAT
- Product Name
See other products for "TAG72"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-723 | Mouse Anti-TAG72 Recombinant Antibody (clone Anatumomab); Fab Fragment | FuncS, IF, Neut, ELISA, FC, IP, WB | Mouse Fab (IgG1, κ) |
TAB-H60 | Anti-Human TAG-72 Recombinant Antibody (Satumomab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
TAB-249 | Anti-Human TAG-72 Recombinant Antibody (Minretumomab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 |
TAB-002 | Anti-Human TAG72 Recombinant Antibody (Satumomab Pendetide) | IP, IF, FuncS, FC, Neut, ELISA, WB | IgG1 |
PABX-025-S (P) | Recombinant Human Anti-TAG-72 Antibody scFv Fragment (PABX-025-S (P)) | WB, Neut, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L070E | anti-TAG72 immunotoxin CC49 (scFv)-PE | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBW-119 | Human Anti-TAG72 Recombinant Antibody (clone HuCC49DeltaCH2); scFv Fragment | WB, ELISA | Humanized scFv |
FAMAB-0315CQ-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone ACT19); scFv Fragment | ELISA | Mouse scFv |
FAMAB-0317CQ-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone CC49); scFv Fragment | WB, IP, IF, IHC, FC | Mouse scFv |
FAMAB-0119-CN-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone B72.3); scFv Fragment | WB, ELISA | Mouse scFv |
FAMAB-0120-CN-S(P) | Human Anti-TAG72 Recombinant Antibody (clone ccM4); scFv Fragment | WB, ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0285CL | Human Anti-TAG72 Recombinant Antibody (TAB-0285CL) | DB, IHC, BI, SPR | Human IgG |
TAB-0286CL | Human Anti-TAG72 Recombinant Antibody (TAB-0286CL) | DB, IHC, BI, SPR | Human IgG |
TAB-0285CL-S(P) | Human Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-0285CL-S(P)) | DB, IHC, BI, SPR | Human scFv |
TAB-0286CL-S(P) | Human Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-0286CL-S(P)) | DB, IHC, BI, SPR | Human scFv |
TAB-0285CL-F(E) | Human Anti-TAG72 Recombinant Antibody; Fab Fragment (TAB-0285CL-F(E)) | DB, IHC, BI, SPR | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-505CT | Humanized Anti-TAG72 Recombinant Antibody (TAB-505CT) | WB, ELISA | Humanized antibody |
TAB-505CT-S(P) | Humanized Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-505CT-S(P)) | WB, ELISA | Humanized scFv |
TAB-505CT-F(E) | Humanized Anti-TAG72 Recombinant Antibody; Fab Fragment (TAB-505CT-F(E)) | WB, ELISA | Humanized Fab |
PABX-025 | Recombinant Human Anti-TAG-72 Antibody (PABX-025) | WB, Neut, FuncS, ELISA, Cyt | IgG |
PABX-025-F (E) | Recombinant Human Anti-TAG-72 Antibody Fab Fragment (PABX-025-F (E)) | WB, Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-016LC | Recombinant Anti-Human TAG-72 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0315CQ-F(E) | Mouse Anti-TAG72 Recombinant Antibody (clone ACT19); Fab Fragment | ELISA | Mouse Fab |
FAMAB-0316CQ-F(E) | Human Anti-TAG72 Recombinant Antibody (clone cACT19); Fab Fragment | ELISA | Human Fab |
FAMAB-0317CQ-F(E) | Mouse Anti-TAG72 Recombinant Antibody (clone CC49); Fab Fragment | WB, IP, IF, IHC, FC | Mouse Fab |
FAMAB-0119-CN-F(E) | Mouse Anti-TAG72 Recombinant Antibody (clone B72.3); Fab Fragment | WB, ELISA | Mouse Fab |
FAMAB-0120-CN-F(E) | Human Anti-TAG72 Recombinant Antibody (clone ccM4); Fab Fragment | WB, ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0119-CN | Mouse Anti-TAG72 Recombinant Antibody (clone B72.3) | WB, ELISA | Mouse IgG |
FAMAB-0120-CN | Human Anti-TAG72 Recombinant Antibody (clone ccM4) | WB, ELISA | Chimeric (mouse/human) IgG1, Κ |
FAMAB-0121-CN | Human Anti-TAG72 Recombinant Antibody (clone hmM4) | WB, ELISA | Humanized IgG1 |
FAMAB-0122-CN | Human Anti-TAG72 Recombinant Antibody (clone FV/M4) | WB, ELISA | Chimeric (mouse/human) IgG |
HPAB-A1328-YJ | Human Anti-TAG-72 Recombinant Antibody (clone hum4) | ELISA, Inhib, and SPR | Human IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0123-CN | Mouse Anti-TAG72 Recombinant Antibody (clone TKH6) | WB, ELISA | Mouse IgM, Κ |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-249 | Afuco™ Anti-TAG72 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-249) | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-H60 | Afuco™ Anti-TAG72 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H60) | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
VS-0425-FY190 | Mouse Anti-TAG-72 (clone Satumomab) scFv-Fc Chimera | ELISA | Mouse IgG1, scFv-Fc |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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