Human Anti-TAG72 (clone hum4) scFv-Fc Chimera

CAT#: VS-0125-FY87

Anti-TAG-72 scFv-Fc is an antibody constructed by fusing a single-chain variable fragment (scFv) with an Fc fragment, specifically targeting tumor-associated glycoprotein 72 (TAG-72). TAG-72 is a tumor marker that is highly expressed in various cancers, particularly in solid tumors such as breast cancer and colon cancer. By targeting TAG-72, anti-TAG-72 scFv-Fc has the potential to serve as an effective cancer therapeutic strategy.

Specifications

  • Host Species
  • Human
  • Type
  • Human IgG1, scFv-Fc
  • Species Reactivity
  • Human
  • Clone
  • hum4
  • Applications
  • ELISA, Inhibition, Surface Plasmon Resonance, Antibody-dependent cellular cytotoxicity
  • Related Disease
  • Cancer

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Format
  • Liquid
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Stabilizer
  • No Stabilizers
  • Sterility
  • 0.2 μM filtered
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • The single-chain antibody fragment (scFv), comprising the variable regions from both the light and heavy chains of antibodies, has the potential to selectively bind to target antigens such as TAG-72. In contrast, the Fc fragment, consisting of the antibody's constant region, offers enhanced stability and prolongs the antibody's half-life in the bloodstream. Additionally, the Fc fragment's capability to engage with cell surface Fcγ receptors may allow for the modulation of various antibody functions, including the potential promotion of antibody-dependent cellular cytotoxicity (ADCC).

Target

  • Alternative Names
  • TAG-72, Cancer Antigen 72-4 (CA 72-4), MUC1
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Secondary Antibody

Isotype Control

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