Human Anti-TCR (clone BMA031) scFv-Fc Chimera (CAT#: VS-0425-FY48)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• The BMA031 monoclonal antibody specifically binds to the T cell antigen receptor (TCR).

• Species Reactivity
• Human

• Clone
• BMA031

• Applications
• Flow Cytometry

• Related Disease
• Autoimmune Disease, T-cell malignancies

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• TCR; T cell receptor; TCRA; TCRB

• Long Name
• T-cell receptor

• Function
• The TCR genes encode for the T cell receptor (TCR), a crucial protein complex on the surface of T lymphocytes. The primary function of the TCR is to recognize specific peptide antigens presented by Major Histocompatibility Complex (MHC) molecules on antigen-presenting cells (APCs).
  Each T cell expresses a unique TCR due to somatic recombination of the TCR genes, generating a vast repertoire capable of recognizing diverse antigens. The TCR itself consists of variable α and β chains (or γ and δ chains in a smaller subset of T cells) that form the antigen-binding site.
  Upon binding to a specific peptide-MHC complex, the TCR initiates intracellular signaling cascades via associated CD3 molecules. This leads to T cell activation, resulting in proliferation, differentiation into effector cells (like cytotoxic T cells or helper T cells), cytokine production, and ultimately, the elimination of the recognized threat. The TCR is thus central to adaptive immunity, enabling targeted and specific immune responses.

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