Human Anti-TCR (clone BMA031) scFv-Fc Chimera
CAT#: VS-0425-FY48
The anti-TCR scFv-Fc fusion protein is designed to target the T-cell receptor (TCR), a critical component of T-cell activation. This fusion protein strategically links a single-chain variable fragment (scFv), which provides precise TCR recognition, to an Fc region that boosts stability and functionality. The primary function of this protein lies in modulating T-cell responses by binding to the TCR, leading to the inhibition or alteration of T-cell mediated immune reaction. This modulatory function shows promise in the treatment of autoimmune diseases and transplant rejection. Through it's Fc portion the protein has prolonged action in the body. Future research and development are concentrating on refining its specificity and therapeutic application.
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Antibody Isotype
- scFv-Fc
- Specificity
- The BMA031 monoclonal antibody specifically binds to the T cell antigen receptor (TCR).
- Species Reactivity
- Human
- Clone
- BMA031
- Applications
- Flow Cytometry
- Related Disease
- Autoimmune Disease, T-cell malignancies
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- TCR; T cell receptor; TCRA; TCRB
- Long Name
- T-cell receptor
- Function
- The TCR genes encode for the T cell receptor (TCR), a crucial protein complex on the surface of T lymphocytes. The primary function of the TCR is to recognize specific peptide antigens presented by Major Histocompatibility Complex (MHC) molecules on antigen-presenting cells (APCs).
Each T cell expresses a unique TCR due to somatic recombination of the TCR genes, generating a vast repertoire capable of recognizing diverse antigens. The TCR itself consists of variable α and β chains (or γ and δ chains in a smaller subset of T cells) that form the antigen-binding site.
Upon binding to a specific peptide-MHC complex, the TCR initiates intracellular signaling cascades via associated CD3 molecules. This leads to T cell activation, resulting in proliferation, differentiation into effector cells (like cytotoxic T cells or helper T cells), cytokine production, and ultimately, the elimination of the recognized threat. The TCR is thus central to adaptive immunity, enabling targeted and specific immune responses.
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Related Diseases
Asthma
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Amyotrophic Lateral Sclerosis
Maturity Onset Diabetes of the Young
Related Signaling Pathways
TCR Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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