Human Anti-TFPI (clone Concizumab) scFv-Fc Chimera
CAT#: VS-0425-FY189
The anti-TFPI scFv-FC is a monoclonal antibody designed to target Tissue Factor Pathway Inhibitor (TFPI). The scFv-FC format combines a single-chain variable fragment (scFv) that specifically binds to TFPI with the human Fc domain, enhancing its stability, half-life, and potential for therapeutic applications. This antibody can be used for research, diagnostic, and therapeutic purposes, particularly in the fields of coagulation and vascular biology.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human smooth muscle
Immunohistochemical staining of human smooth muscle shows distinct positivity in endothelial.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5575/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows distinct cytoplasmic positivity in endothelium.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endocrine cells Staining: High Intensity: Strong Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_7_3.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_4_6.jpg
Normal Tissue
Figure 6 Placenta
Decidual cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_2_7.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HHSteC, HUVEC TERT2, LHCN-M2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000003436-TFPI
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Specifications
- Immunogen
- Human TFPI as an immunogen.
- Host Species
- Human
- Type
- Human IgG4, scFv-Fc
- Specificity
- Human TFPI
- Species Reactivity
- Human
- Clone
- Concizumab
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Willebrand's disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Tissue Factor Pathway Inhibitor; Extrinsic Pathway Inhibitor; Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor); TFPI1; LACI; EPI; Lipoprotein-Associated Coagulation Inhibitor; Anti-Convertin; TFI
- Gene ID
- 7035
- UniProt ID
- P10646
- Long Name
- Tissue Factor Pathway Inhibitor
- Cellular Localization
- Endoplasmic reticulum, Membrane, Microsome, Secreted
- Post Translation Modifications
- O-glycosylated.
- Protein Refseq
- NP_001027452.1; NP_001305870.1; NP_001316168.1
- Function
- Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "TFPI"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-734 | Anti-TFPI Recombinant Antibody (Concizumab) | ELISA, IP, FC, FuncS, Neut, IF, WB | IgG4 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3547 | Rabbit Anti-TFPI Recombinant Antibody (clone DS3547AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0428-YC-S(P) | Human Anti-TFPI Recombinant Antibody (clone TFPI-106); scFv Fragment | ELISA, FC, FuncS | Human scFv |
| HPAB-0429-YC-S(P) | Human Anti-TFPI Recombinant Antibody (clone TFPI-118); scFv Fragment | ELISA, FC, FuncS | Human scFv |
| HPAB-0431-YC-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-0431-YC-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-0779-CN-S(P) | Mouse Anti-TFPI Recombinant Antibody (clone 3F18); scFv Fragment | ELISA, Neut | Mouse scFv |
| HPAB-2580LY-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-2580LY-S(P)) | ELISA, WB, FuncS | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-539 | Human Anti-TFPI Recombinant Antibody (clone ch2F22); Fab Fragment | ELISA, FC, Neut | Chimeric (mouse/human) Fab |
| HPAB-2587LY-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-2587LY-F(E)) | ELISA, WB, FuncS | Human Fab |
| HPAB-2588LY-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-2588LY-F(E)) | ELISA, WB, FuncS | Human Fab |
| HPAB-2589LY-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-2589LY-F(E)) | ELISA, WB, FuncS | Human Fab |
| HPAB-2590LY-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-2590LY-F(E)) | ELISA, WB, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-734 | Afuco™ Anti-TFPI ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-734) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2598LY | Human Anti-TFPI Recombinant Antibody (HPAB-2598LY) | ELISA, WB, FuncS | Human IgG |
| HPAB-2599LY | Human Anti-TFPI Recombinant Antibody (HPAB-2599LY) | ELISA, WB, FuncS | Human IgG |
| HPAB-2600LY | Human Anti-TFPI Recombinant Antibody (HPAB-2600LY) | ELISA, WB, FuncS | Human IgG |
| HPAB-2601LY | Human Anti-TFPI Recombinant Antibody (HPAB-2601LY) | ELISA, WB, FuncS | Human IgG |
| HPAB-2602LY | Human Anti-TFPI Recombinant Antibody (HPAB-2602LY) | ELISA, WB, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC647 | AbPlus™ Anti-TFPI Magnetic Beads (VS-0724-YC647) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7198 | Anti-TFPI Immunohistochemistry Kit | IHC |
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