Human Anti-TFPI (clone Concizumab) scFv-Fc Chimera (CAT#: VS-0425-FY189)
The anti-TFPI scFv-FC is a monoclonal antibody designed to target Tissue Factor Pathway Inhibitor (TFPI). The scFv-FC format combines a single-chain variable fragment (scFv) that specifically binds to TFPI with the human Fc domain, enhancing its stability, half-life, and potential for therapeutic applications. This antibody can be used for research, diagnostic, and therapeutic purposes, particularly in the fields of coagulation and vascular biology.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human smooth muscle
(Immunohistochemical staining of human smooth muscle shows distinct positivity in endothelial.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5575/ihc_selected.jpg
(Immunohistochemical staining of human smooth muscle shows distinct positivity in endothelial.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5575/ihc_selected.jpg
Figure 2 IHC staining of human colon
(Immunohistochemical staining of human colon shows distinct cytoplasmic positivity in endothelium.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/ihc_selected.jpg
(Immunohistochemical staining of human colon shows distinct cytoplasmic positivity in endothelium.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/ihc_selected.jpg
Figure 3 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_B_9_5.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_B_9_5.jpg
Figure 4 Colon
(Endocrine cells Staining: High Intensity: Strong Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_7_3.jpg
(Endocrine cells Staining: High Intensity: Strong Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_7_3.jpg
Figure 5 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_4_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_4_6.jpg
Figure 6 Placenta
(Decidual cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_2_7.jpg
(Decidual cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_2_7.jpg
Figure 7 RNA cell line category: Cell line enhanced (HHSteC, HUVEC TERT2, LHCN-M2, TIME)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000003436-TFPI
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000003436-TFPI
Specifications
- Immunogen
- Human TFPI as an immunogen.
- Host Species
- Human
- Type
- Human IgG4, scFv-Fc
- Specificity
- Human TFPI
- Species Reactivity
- Human
- Clone
- Concizumab
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Willebrand's disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Tissue Factor Pathway Inhibitor; Extrinsic Pathway Inhibitor; Tissue Factor Pathway Inhibitor (Lipoprotein-Associated Coagulation Inhibitor); TFPI1; LACI; EPI; Lipoprotein-Associated Coagulation Inhibitor; Anti-Convertin; TFI
- Gene ID
- 7035
- UniProt ID
- P10646
- Long Name
- Tissue Factor Pathway Inhibitor
- Cellular Localization
- Endoplasmic reticulum, Membrane, Microsome, Secreted
- Post Translation Modifications
- O-glycosylated.
- Protein Refseq
- NP_001027452.1; NP_001305870.1; NP_001316168.1
- Function
- Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3593z | Mouse Anti-TFPI Recombinant Antibody (clone 41B4) | WB, IP, IF, ELISA | Mouse IgG1, κ |
| HPAB-0476-CN | Mouse Anti-TFPI Recombinant Antibody (HPAB-0476-CN) | ELISA | Mouse IgG |
| HPAB-0477-CN | Human Anti-TFPI Recombinant Antibody (HPAB-0477-CN) | ELISA, Neut | Chimeric (mouse/human) IgG1, κ |
| HPAB-0478-CN | Human Anti-TFPI Recombinant Antibody (HPAB-0478-CN) | ELISA, Neut | Humanized IgG1, κ |
| HPAB-0479-CN | Human Anti-TFPI Recombinant Antibody (HPAB-0479-CN) | ELISA, Neut | Human IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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