Human Anti-TIMP1 (clone mab1) scFv-Fc Chimera
CAT#: VS-0325-FY147
The Anti-TIMP-1 scFv-Fc antibody is a recombinant antibody targeting human Tissue Inhibitor of Metalloproteinase-1 (TIMP-1). It utilizes a format of a single-chain variable fragment (scFv) fused to the Fc region of human immunoglobulin G (IgG). This design confers unique advantages to the antibody: the scFv portion retains antigen-binding specificity, while the Fc portion enhances antibody stability and effector functions. This antibody specifically recognizes a particular form of TIMP-1, especially the forms associated with aberrant glycosylation in cancer progression.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22360/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human prostate
Immunohistochemical staining of human prostate shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53417/ihc_selected.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53417/139501_A_7_5.jpg
Normal Tissue
Figure 4 Prostate
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53417/139501_A_2_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000102265-TIMP1
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human TIMP1
- Species Reactivity
- Human
- Clone
- mab1
- Applications
- ELISA
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- TIMP Metallopeptidase Inhibitor 1; Tissue Inhibitor Of Metalloproteinases 1; Fibroblast Collagenase Inhibitor; Collagenase Inhibitor; TIMP-1; CLGI; TIMP; EPA
- Gene ID
- 7076
- UniProt ID
- P01033
- Long Name
- TIMP Metallopeptidase Inhibitor 1
- Cellular Localization
- Secreted
- Function
- TIMP1 is a protein that inhibits the activity of matrix metalloproteinases (MMPs), a family of enzymes responsible for the degradation of the extracellular matrix (ECM). By regulating MMP activity, TIMP1 plays a vital role in maintaining ECM homeostasis, influencing processes such as tissue remodeling, wound healing, and angiogenesis. Dysregulation of TIMP1 has implications in various pathological conditions, including cancer and fibrosis.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "TIMP1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1378z | Mouse Anti-TIMP1 Recombinant Antibody (clone 39D12) | WB, ELISA | Mouse IgG1 |
| HPAB-0174-YC | Human Anti-TIMP1 Recombinant Antibody (clone HuCAL) | ELISA | Human IgG |
| ZG-0154U | Mouse Anti-Timp1 Recombinant Antibody (clone 4A2B1) | ELISA, IHC | Mouse IgG1 |
| VS3-XY1527 | Mouse Anti-TIMP1 Recombinant Antibody (clone 4C2) | WB, IHC, ICC, IF | Mouse IgG |
| VS3-XY3526 | Rabbit Anti-TIMP1 Recombinant Antibody (clone R03-9H5) | WB, IHC-P, ICC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-683CT | Anti-Human TIMP-1 Recombinant Antibody (MS-BW-3 ) | ELISA, BL | Human antibody |
| TAB-683CT-S(P) | Anti-Human TIMP-1 Recombinant Antibody scFv Fragment (MS-BW-3 ) | ELISA, BL | Human antibody |
| TAB-684CT-S(P) | Anti-Human TIMP-1 Recombinant Antibody scFv Fragment (MS-BW-28) | ELISA, BL | Human antibody |
| TAB-685CT-S(P) | Anti-Human TIMP-1 Recombinant Antibody scFv Fragment (MS-BW-1) | ELISA, BL | Human antibody |
| TAB-686CT-S(P) | Anti-Human TIMP-1 Recombinant Antibody scFv Fragment (MS-BW-27) | ELISA, BL | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3575 | Rabbit Anti-TIMP1 Recombinant Antibody (clone DS3575AB) | WB | Rabbit IgG |
| MOR-4458 | Rabbit Anti-TIMP1 Recombinant Antibody (clone SI552DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1976 | PE-B7/Human TIMP1 (APFEPLASGIL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0174-YC-S(P) | Human Anti-TIMP1 Recombinant Antibody (clone HuCAL); scFv Fragment | ELISA | Human scFv |
| HPAB-0192-WJ-S(P) | Human Anti-TIMP1 Recombinant Antibody; scFv Fragment (HPAB-0192-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0174-YC-F(E) | Human Anti-TIMP1 Recombinant Antibody (clone HuCAL); Fab Fragment | ELISA | Human Fab |
| HPAB-0192-WJ-F(E) | Human Anti-TIMP1 Recombinant Antibody; Fab Fragment (HPAB-0192-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7268 | Anti-TIMP1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7269 | Anti-Mouse TIMP1 Immunohistochemistry Kit | IHC |
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