Human Anti-TPBG (clone H8) scFv-Fc Chimera
CAT#: VS-0425-FY60
The fusion of an scFv specific to TPBG (Trophoblast glycoprotein) with an Fc region creates a targeted therapy for cancers, such as gastric cancer, that overexpress TPBG, potentially improving treatment efficacy through precise targeting.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10554/if_selected.jpg
Normal Tissue
Figure 2 Seminal vesicle
High expression in seminal vesicle
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10554/26240_A_7_6_val_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10554/26240_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10554/26240_A_7_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10554/26240_A_9_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10554/26240_A_8_5.jpg
Normal Tissue
Figure 7 Placenta
Decidual cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10554/26240_A_2_7.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000146242-TPBG
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human TPBG
- Species Reactivity
- Human
- Clone
- H8
- Applications
- Flow Cytometry, ELISA
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 250 ng/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Trophoblast Glycoprotein; 5T4 Oncofetal Trophoblast Glycoprotein; Wnt-Activated Inhibitory Factor 1; 5T4 Oncotrophoblast Glycoprotein; 5T4 Oncofetal Antigen; WAIF1; M6P1; 5T4; 5T4AG
- Gene ID
- 7162
- UniProt ID
- Q13641
- Long Name
- Trophoblast Glycoprotein
- Cellular Localization
- Cell membrane, Membrane
- Post Translation Modifications
- Highly glycosylated.
- Protein Refseq
- NP_001159864.1; NP_006661.1
- Function
- May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "Clone H8"
- CAT
- Product Name
See other products for "TPBG"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-118-F(E) | Anti-Human 5T4 Recombinant Antibody Fab Fragment, 5T4 (TAB-118-F(E)) | FuncS, IF, Neut, ELISA, FC, IP, ICC | Fab - G1 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3649 | Rabbit Anti-TPBG Recombinant Antibody (clone DS3649AB) | WB, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0088CQ | Human Anti-TPBG Recombinant Antibody (HPAB-0088CQ) | ELISA, FC, FuncS | Human IgG1, κ |
| HPAB-0089CQ | Human Anti-TPBG Recombinant Antibody (HPAB-0089CQ) | ELISA, FC, FuncS | Human IgG1, κ |
| HPAB-0090CQ | Human Anti-TPBG Recombinant Antibody (HPAB-0090CQ) | ELISA, FC, FuncS | Human IgG1, κ |
| HPAB-0091CQ | Mouse Anti-TPBG Recombinant Antibody (HPAB-0091CQ) | ELISA, FC, FuncS | Mouse IgG, κ |
| HPAB-0092CQ | Mouse Anti-TPBG Recombinant Antibody (HPAB-0092CQ) | ELISA, FC | Mouse IgG, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0088CQ-S(P) | Human Anti-TPBG Recombinant Antibody; scFv Fragment (HPAB-0088CQ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0089CQ-S(P) | Human Anti-TPBG Recombinant Antibody; scFv Fragment (HPAB-0089CQ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0287-WJ-S(P) | Rabbit Anti-TPBG Recombinant Antibody; scFv Fragment (HPAB-0287-WJ-S(P)) | ELISA, FC | Rabbit scFv |
| HPAB-0288-WJ-S(P) | Human Anti-TPBG Recombinant Antibody; scFv Fragment (HPAB-0288-WJ-S(P)) | ELISA, FC | Human scFv |
| HPAB-0645-WJ-S(P) | Human Anti-TPBG Recombinant Antibody; scFv Fragment (HPAB-0645-WJ-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0088CQ-F(E) | Human Anti-TPBG Recombinant Antibody; Fab Fragment (HPAB-0088CQ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0089CQ-F(E) | Human Anti-TPBG Recombinant Antibody; Fab Fragment (HPAB-0089CQ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0090CQ-F(E) | Human Anti-TPBG Recombinant Antibody; Fab Fragment (HPAB-0090CQ-F(E)) | ELISA, FC | Human Fab |
| HPAB-0091CQ-F(E) | Mouse Anti-TPBG Recombinant Antibody; Fab Fragment (HPAB-0091CQ-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0092CQ-F(E) | Mouse Anti-TPBG Recombinant Antibody; Fab Fragment (HPAB-0092CQ-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1281 | PE-H-2Db/Human TPBG (ASFRNLTHL) MHC Tetramer | FCM, IHC | |
| MHC-CN1282 | APC-H-2Db/Human TPBG (ASFRNLTHL) MHC Tetramer | FCM, IHC | |
| MHC-CN1283 | FITC-H-2Db/Human TPBG (ASFRNLTHL) MHC Tetramer | FCM, IHC | |
| MHC-CN1284 | H-2Db/Human TPBG (ASFRNLTHL) MHC Tetramer | FCM, IHC | |
| MHC-YF310 | A*02:01/Human 5T4 (FLTGNQLAV) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY114 | Human Anti-TPBG (clone ASN004) scFv-Fc Chimera | ELISA, FC, FuncS | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC638 | Recombinant Anti-TPBG Vesicular Antibody, EV Displayed (VS-0425-YC638) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7454 | Anti-TPBG Immunohistochemistry Kit | IHC | |
| VS-0525-XY7455 | Anti-Mouse TPBG Immunohistochemistry Kit | IHC |
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