Human Anti-TPT1 scFv-Fc Chimera (VS-0325-FY50)
CAT#: VS-0325-FY50
The recombinant single-chain variable fragments (scFv) fused to the Fc region of human IgG1. It was generated by phage display and target different epitopes on human TCTP. The antibody is potential therapeutic candidates for treating allergic airway inflammation.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/39437/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8364/19887_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8364/19887_A_7_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: nuclear Cells in tubules Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8364/19887_A_8_5.jpg
Normal Tissue
Figure 5 Urinary bladder
Urothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8364/19887_A_4_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8364/19887_A_4_6.jpg
Normal Tissue
Figure 7 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8364/19887_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000133112-TPT1
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Specifications
- Immunogen
- Recombinant human mTCTP and dTCTP.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- The antibody binds both monomeric and dimeric forms.
- Species Reactivity
- Human
- Applications
- Inhibition, ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The antibody showed the highest affinity for both forms of TCTP, with EC₅₀ value of about 11 ng/mL.
Target
- Alternative Names
- Tumor Protein, Translationally-Controlled 1; Histamine-Releasing Factor; Fortilin; TCTP; P23; HRF; Translationally-Controlled Tumor Protein; P02
- Gene ID
- 7178
- UniProt ID
- P13693
- Long Name
- Tumor Protein, Translationally-Controlled 1
- Sequence Similarities
- Belongs to the TCTP family.
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- Ubiquitination at Lys102 and Lys164
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001273201.1; NP_001273202.1; NP_003286.1
- Function
- Acts as a negative regulator of TSC22D1-mediated apoptosis, via interaction with and destabilization of TSC22D1 protein.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "TPT1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1998CT | Recombinant Mouse anti-Human TPT1 Monoclonal antibody (EML2384) | WB | |
| MRO-1477-CN | Rabbit Anti-TPT1 Recombinant Antibody (clone JU13-32) | WB, IF, IHC, FC, IP | Rabbit IgG |
| ZG-0607U | Rabbit Anti-TPT1 Recombinant Antibody (clone 10A9) | ELISA, WB, IHC, IF, IP | Rabbit IgG |
| VS-0923-FY149 | Recombinant Mouse Anti-TPT1 Antibody (VS-0923-FY149) | ELISA, WB | Mouse IgG1 |
| VS3-FY1896 | Rabbit Anti-TPT1 Recombinant Antibody (clone R02-5D7) | WB, IF, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3664 | Rabbit Anti-TPT1 Recombinant Antibody (clone DS3664AB) | WB, IHC, ICC, IP, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC605 | AbPlus™ Anti-TPT1 Magnetic Beads (VS-0724-YC605) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2341 | Anti-TPT1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7481 | Anti-Mouse TPT1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7480 | Anti-Human TPT1 Immunohistochemistry Kit | IHC |
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