Human Anti-TRBC1 (clone IARC307) scFv-Fc Chimera
CAT#: VS-0325-FY5
The Anti-TRBC1 scFv-Fc Antibody is designed to target the TRBC1 protein. It provides high specificity and sensitivity, making it a valuable tool for research. This antibody can be used in studies involving immune cell function and differentiation.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Cell line enriched (JURKAT)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000211751-TRBC1
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human TRBC1
- Species Reactivity
- Human
- Clone
- IARC307
- Applications
- ELISA, Flow Cytometry, Immunofluorescence
- Related Disease
- T-cell lymphoma or leukaemia
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- T Cell Receptor Beta Constant 1; V_segment Translation Product; BV05S1J2.2; TCRBC1; TCRB
- Gene ID
- 28639
- UniProt ID
- P01850
- Long Name
- T Cell Receptor Beta Constant 1
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn69
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site
- Function
- Constant region of T cell receptor (TR) beta chain (PubMed:24600447).
Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes.
Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333).
Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "Clone IARC307"
- CAT
- Product Name
See other products for "TRBC1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1510CQ | Human Anti-TRBC1 Recombinant Antibody (clone IARC307) | ELISA, FC, IF | Human IgG1 |
| VS13-YC1183 | Rabbit Anti-TRBC1 Recombinant Antibody (VS13-YC1183) | IHC-P | Rabbit IgG |
| VS7-0425-WR1042 | Mouse Anti-TRBC1 Recombinant Antibody (clone 5A8A10) | IHC, FC | Mouse IgG1 |
| VS7-0425-WR1043 | Mouse Anti-TRBC1 Recombinant Antibody (clone 5D9F1) | WB, IHC, ICC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC695 | Recombinant Anti-TRBC1 Vesicular Antibody, EV Displayed (VS-0425-YC695) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7501 | Anti-TRBC1 Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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