Human Anti-TSLP (clone MOR04494) scFv-Fc Chimera
CAT#: VS-0125-FY50
This is a fully human anti-TSLP scFv-Fc recombinant antibody, with a molecular weight of approximately 50 kDa. The main function of this antibody is to inhibit the interaction between TSLP and its receptor by binding to TSLP, thereby blocking TSLP signaling. This mechanism may play an important role in the treatment of diseases caused by abnormal immune responses mediated by TSLP, such as asthma and certain types of malignancies.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to the Golgi apparatus & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56350/1512_A1_5_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000145777-TSLP
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- MOR04494
- Applications
- ELISA, Flow Cytometry, Western Blot, Inhibition
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The anti-TSLP-scFv-Fc antibody inhibits the binding of TSLP to its receptor by binding to TSLP itself, thereby blocking TSLP signal transduction. This function has the potential to aid in the treatment of diseases caused by abnormal immune responses mediated by TSLP, such as asthma and certain malignancies.
Target
- Alternative Names
- Thymic Stromal Lymphopoietin
- Gene ID
- 85480
- UniProt ID
- Q969D9
- Cellular Localization
- Secreted
- Protein Refseq
- NP_149024.1; NP_612561.2; XP_011542000.1
- Function
- Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells.
Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "Clone MOR04494"
- CAT
- Product Name
See other products for "TSLP"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2482-sdAb | Recombinant Anti-Human TSLP VHH Single Domain Antibody | ICC, ChiP, FC, FA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-652CL | Human Anti-TSLP Recombinant Antibody (TAB-652CL) | FuncS | Human IgG2λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-626CL | Afuco™ Anti-TSLP Recombinant Antibody (AFC-626CL), ADCC Enhanced | ELISA, WB | Human IgG1, λ |
| AFC-TAB-454CQ | Afuco™ Anti-TSLP Recombinant Antibody (AFC-TAB-454CQ), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | Human IgG1, λ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-195CQ | Rat Anti-TSLP Recombinant Antibody (TAB-195CQ) | ELISA, FC, Neut | Rat IgG1 |
| TAB-195CQ-S(P) | Rat Anti-TSLP Recombinant Antibody; scFv Fragment (TAB-195CQ-S(P)) | ELISA, FC, Neut | Rat scFv |
| TAB-195CQ-F(E) | Rat Anti-TSLP Recombinant Antibody; Fab Fragment (TAB-195CQ-F(E)) | ELISA, FC, Neut | Rat Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-196CQ | Human Anti-TSLP Recombinant Antibody (TAB-196CQ) | ELISA, FC, Neut | Humanized antibody |
| TAB-196CQ-S(P) | Human Anti-TSLP Recombinant Antibody; scFv Fragment (TAB-196CQ-S(P)) | ELISA, FC, Neut | Humanized scFv |
| TAB-196CQ-F(E) | Human Anti-TSLP Recombinant Antibody; Fab Fragment (TAB-196CQ-F(E)) | ELISA, FC, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-193CQ-F(E) | Anti-Human TSLP Recombinant Antibody Fab Fragment (MOR04494) | ELISA, FC, WB | Human antibody |
| TAB-194CQ-F(E) | Anti-Human TSLP Recombinant Antibody Fab Fragment (MOR04493) | ELISA, FC, WB | Human antibody |
| TAB-197CQ-F(E) | Human Anti-TSLP Recombinant Antibody; Fab Fragment (TAB-197CQ-F(E)) | ELISA, WB | Human Fab |
| TAB-198CQ-F(E) | Human Anti-TSLP Recombinant Antibody; Fab Fragment (TAB-198CQ-F(E)) | ELISA, WB | Human Fab |
| TAB-199CQ-F(E) | Human Anti-TSLP Recombinant Antibody; Fab Fragment (TAB-199CQ-F(E)) | ELISA, WB | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2235CQ | Rat Anti-Tslp Recombinant Antibody (clone 28F12) | ELISA, Neut | Rat IgG2a, κ |
| NEUT-2236CQ | Rat Anti-Tslp Recombinant Antibody (clone CBL399) | Neut | Rat IgG2a |
| NEUT-2237CQ | Rat Anti-Tslp Recombinant Antibody (clone CBL705) | WB, Neut | Rat IgG2a |
| NEUT-2238CQ | Mouse Anti-TSLP Recombinant Antibody (clone 15B11.3) | ELISA, Neut | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0068LY | Human Anti-TSLP Recombinant Antibody (HPAB-0068LY) | ELISA | Human IgG |
| HPAB-0069LY | Human Anti-TSLP Recombinant Antibody (HPAB-0069LY) | ELISA | Human IgG |
| HPAB-0070LY | Human Anti-TSLP Recombinant Antibody (HPAB-0070LY) | ELISA | Human IgG |
| HPAB-0071LY | Human Anti-TSLP Recombinant Antibody (HPAB-0071LY) | ELISA | Human IgG |
| HPAB-0072LY | Human Anti-TSLP Recombinant Antibody (clone MOR05018) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0057LY-S(P) | Human Anti-TSLP Recombinant Antibody (clone MOR05155); scfv Fragment | ELISA | Human scfv |
| HPAB-0058LY-S(P) | Human Anti-TSLP Recombinant Antibody (clone MOR04496); scfv Fragment | ELISA | Human scfv |
| HPAB-0059LY-S(P) | Human Anti-TSLP Recombinant Antibody (clone MOR04497); scfv Fragment | ELISA | Human scfv |
| HPAB-0060LY-S(P) | Human Anti-TSLP Recombinant Antibody scFv Fragment (HPAB-0060LY-S(P)) | ELISA | Human scfv |
| HPAB-0061LY-S(P) | Human Anti-TSLP Recombinant Antibody (clone MOR04832); scfv Fragment | ELISA | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0057LY-F(E) | Human Anti-TSLP Recombinant Antibody (clone MOR05155); Fab Fragment | ELISA | Human Fab |
| HPAB-0058LY-F(E) | Human Anti-TSLP Recombinant Antibody (clone MOR04496); Fab Fragment | ELISA | Human Fab |
| HPAB-0059LY-F(E) | Human Anti-TSLP Recombinant Antibody (clone MOR04497); Fab Fragment | ELISA | Human Fab |
| HPAB-0060LY-F(E) | Human Anti-TSLP Recombinant Antibody Fab Fragment (HPAB-0060LY-F(E)) | ELISA | Human Fab |
| HPAB-0061LY-F(E) | Human Anti-TSLP Recombinant Antibody (clone MOR04832); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7573 | Anti-TSLP Immunohistochemistry Kit | IHC | |
| VS-0525-XY7574 | Anti-Human TSLP Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC14 | Recombinant Anti-TSLP Biparatopic Antibody, Asymmetric hetero HC-LC | ELISA | Asymmetric hetero HC, common LC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC320 | Recombinant Anti-TSLP Eliminating Antibody, pH-Sensitive (VS-0625-YC320) | Antigen-Sweeping In Vivo. | Human IgG |
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