Human Anti-TSLP (clone MOR04494) scFv-Fc Chimera (CAT#: VS-0125-FY50)
This is a fully human anti-TSLP scFv-Fc recombinant antibody, with a molecular weight of approximately 50 kDa. The main function of this antibody is to inhibit the interaction between TSLP and its receptor by binding to TSLP, thereby blocking TSLP signaling. This mechanism may play an important role in the treatment of diseases caused by abnormal immune responses mediated by TSLP, such as asthma and certain types of malignancies.
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Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to the Golgi apparatus & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56350/1512_A1_5_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to the Golgi apparatus & vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56350/1512_A1_5_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced.
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000145777-TSLP
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000145777-TSLP
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- MOR04494
- Applications
- ELISA, Flow Cytometry, Western Blot, Inhibition
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The anti-TSLP-scFv-Fc antibody inhibits the binding of TSLP to its receptor by binding to TSLP itself, thereby blocking TSLP signal transduction. This function has the potential to aid in the treatment of diseases caused by abnormal immune responses mediated by TSLP, such as asthma and certain malignancies.
Target
- Alternative Names
- Thymic Stromal Lymphopoietin
- Gene ID
- 85480
- UniProt ID
- Q969D9
- Cellular Localization
- Secreted
- Protein Refseq
- NP_149024.1; NP_612561.2; XP_011542000.1
- Function
- Isoform 1: Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells.
Isoform 2: May act as an antimicrobial peptide in the oral cavity and on the skin.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2482-sdAb | Recombinant Anti-Human TSLP VHH Single Domain Antibody | ICC, ChiP, FC, FA | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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