Human Anti-TSPAN8 scFv-Fc Chimera (VS-0325-FY137)
CAT#: VS-0325-FY137
This product is a novel, human, conformation-dependent antibody targeting the large extracellular loop (LEL) of Tetraspanin 8 (TSPAN8). It was developed using phage display technology and exhibits subnanomolar affinity for TSPAN8-LEL, specifically recognizing amino acids 140-205. The antibody is designed to inhibit the invasion of metastatic colorectal cancer (mCRC) cells that express TSPAN8.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line OE19
Immunofluorescent staining of human cell line OE19 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22273/1971_C4_6_selected.jpg
Normal Tissue
Figure 2 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Microvilli Staining: High Intensity: Strong Goblet cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/44337/125265_A_9_3.jpg
Normal Tissue
Figure 3 Gallbladder
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/44337/125265_A_5_4.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enriched (OE19)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000127324-TSPAN8
❮
❯
Specifications
- Immunogen
- The immunogen was the large extracellular loop of TSPAN8 (TSPAN8-LEL).
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human TSPAN8
- Species Reactivity
- Human
- Applications
- Inhibition
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Tetraspanin 8; Transmembrane 4 Superfamily Member 3; Tumor-Associated Antigen CO-029; Tspan-8; TM4SF3; Tetraspanin-8; CO-029
- Gene ID
- 7103
- UniProt ID
- P19075
- Long Name
- Tetraspanin 8
- Sequence Similarities
- Belongs to the tetraspanin (TM4SF) family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Glycosylation at Asn118
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites, 6 N-linked glycans (1 site), 1 O-linked glycan (1 site)
- Protein Refseq
- XP_054229089.1; NP_001356689.1; NP_004607.1
- Function
- TSPAN8 (Tetraspanin 8) is a transmembrane protein involved in cell adhesion, migration, and signaling. It plays a role in tumor progression and metastasis by modulating integrin function and growth factor receptor signaling.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0325-FY137. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "TSPAN8"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-212CQ | Mouse Anti-TSPAN8 Recombinant Antibody (TAB-212CQ) | ELISA, IF, WB | Mouse IgG |
| TAB-212CQ-S(P) | Mouse Anti-TSPAN8 Recombinant Antibody; scFv Fragment (TAB-212CQ-S(P)) | ELISA, IF, WB | Mouse scFv |
| TAB-212CQ-F(E) | Mouse Anti-TSPAN8 Recombinant Antibody; Fab Fragment (TAB-212CQ-F(E)) | ELISA, IF, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-213CQ | Anti-Human TSPAN8 Recombinant Antibody (mAb4) | ELISA, FC, ICC, IHC | Human antibody |
| TAB-213CQ-S(P) | Anti-Human TSPAN8 Recombinant Antibody scFv Fragment (mAb4) | ELISA, FC, ICC, IHC | Human antibody |
| TAB-213CQ-F(E) | Anti-Human TSPAN8 Recombinant Antibody Fab Fragment (mAb4) | ELISA, FC, ICC, IHC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2064CT | Recombinant Mouse anti-Human TSPAN8 Monoclonal antibody (EML2293) | WB | |
| HPAB-0750-FY | Human Anti-TSPAN8 Recombinant Antibody (HPAB-0750-FY) | WB, Inhib | Chimeric (mouse/human) IgG |
| VS7-0425-WR1061 | Mouse Anti-TSPAN8 Recombinant Antibody (clone 8A4A10) | WB, IHC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0602MZ | Chicken Anti-TSPAN8 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0750-FY-F(E) | Mouse Anti-TSPAN8 Recombinant Antibody; Fab Fragment (HPAB-0750-FY-F(E)) | WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0750-FY-S(P) | Mouse Anti-TSPAN8 Recombinant Antibody; scFv Fragment (HPAB-0750-FY-S(P)) | WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0924-YC100 | Rabbit Anti-TSPAN8 Antibody (VS-0924-YC100) - Cancer Stem Cell Marker | IHC, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY229 | CytoStream™ Rat Anti-TSPAN8 Recombinant Antibody (clone 458811) | FC | Rat IgG2b, kappa |
| VS-0225-XY230 | CytoStream™ Rat Anti-TSPAN8 Recombinant Antibody (clone 657909) | FC | Rat IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC209 | Recombinant Anti-TSPAN8 Vesicular Antibody, EV Displayed (VS-0425-YC209) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7580 | Anti-Mouse TSPAN8 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA, Inhib, FC
Application: ELISA, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
