Recombinant Human Anti-Tyrosinase Soluble TCR (B12) (ZIP-Fos/ZIP-Jun) (CAT#: VS-0622-YF459)
Human TCR (B12) recognizes Tyrosinase peptide (YMDGTMSQV) in the context of HLA-A*0201. Soluble TCR expressed with ZIP-Fos/ZIP-Jun strategy (TRAV-TRAC partial-ZIP-Fos, TRBV-TRBC partial-ZIP-Jun) was validated to be able to bind pMHC in published references. The same expression strategy (ZIP-Fos/ZIP-Jun) is used to express this recombinant Human soluble TCR (B12). Please note that the activity is not guaranteed.

(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/43241/1291_D5_4_selected.jpg

(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000077498-TYR/subcellular
Specifications
- Host Species
- Human
- Target
- Tyrosinase
- Species Reactivity
- Human
- Epitope
- YMDGTMSQV
- MHC
- HLA-A*0201
- Clone
- B12
- Type
- Soluble TCR (ZIP-Fos/ZIP-Jun)
- Related Disease
- Melanomas, gliomas , glioblastoma
- TCR Expression Strategy
- ZIP-Fos/ZIP-Jun strategy: the alpha and beta chain (without transmembrane and cytosolic region) can form heterodimer based on ZIP-Fox/ZIP-Jun. The soluble TCR contains variable regions and partial constant regions.
Target
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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