Human Anti-TYRP1 (clone Flanvotumab) scFv-Fc Chimera (CAT#: VS-0425-FY192)
The anti-TYRP1 scFv-FC is a monoclonal antibody designed to target the Tyrosinase-Related Protein 1 (TYRP1) enzyme. The scFv-FC format combines a single-chain variable fragment (scFv) that specifically binds to TYRP1 with the human Fc domain, enhancing its stability, half-life, and potential for therapeutic applications. This antibody can be used for research, diagnostic, and therapeutic purposes, particularly in the fields of dermatology and oncology.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SK-MEL-30
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/937/1291_B1_3_selected.jpg
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/937/1291_B1_3_selected.jpg
Figure 2 Skin
(Melanocytes
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/937/1995_B_9_1.jpg
(Melanocytes
Staining: High
Intensity: Strong
Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/937/1995_B_9_1.jpg
Figure 3 RNA cell line category: Cell line enriched (SK-MEL-30)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000107165-TYRP1/subcellular
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000107165-TYRP1/subcellular
Specifications
- Immunogen
- The immunogen is human TYRP1.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human TYRP1
- Species Reactivity
- Human
- Clone
- Flanvotumab
- Applications
- Flow Cytometry, ELISA
- Related Disease
- Albinism, Oculocutaneous, Type Iii and Skin/Hair/Eye Pigmentation, Variation In, 11
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN
- Gene ID
- 7306
- UniProt ID
- P17643
- Long Name
- tyrosinase related protein 1
- Sequence Similarities
- Belongs to the tyrosinase family.
- Cellular Localization
- Melanosome membrane
- Post Translation Modifications
- Glycosylated.
Glycosylation at Asn96, Asn104, Asn181, Asn304, Asn350, and Asn385
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 6 sites
- Protein Refseq
- XP_047279797.1; XP_054219718.1; NP_000541.1
- Function
- Plays a role in melanin biosynthesis.
Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+).
May regulate or influence the type of melanin synthesized.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1020 | Recombinant Anti-human TYRP1 Antibody | ELISA, WB, FC, FuncS | IgG |
| MHH-1020 | Recombinant Human Anti-human TYRP1 Antibody | ELISA, IF, FuncS | IgG |
| MRO-1533-CN | Rabbit Anti-TYRP1 Recombinant Antibody (clone JU36-48) | WB, IF, IHC, IP | Rabbit IgG |
| FAMAB-1756CQ | Human Anti-TYRP1 Recombinant Antibody (clone TA99) | IP, WB, ELISA, FC, IF, IHC-Fr | Human IgG1 |
| VS13-YC1196 | Rabbit Anti-TYRP1 Recombinant Antibody (VS13-YC1196) | IHC-P | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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