Mouse Anti-CD27 scFv-Fc Chimera (VS-0425-FY16) (CAT#: VS-0425-FY16)

• Immunogen
• The immunogen was a soluble human CD27-Fc fusion protein.

• Host Species
• Mouse

• Type
• Mouse IgG1, scFv-Fc

• Specificity
• The antibody binds to human CD27.

• Species Reactivity
• Human

• Applications
• Inhibition, ELISA, Flow Cytometry

• Related Disease
• Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Disease

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• CD27 Molecule; Tumor Necrosis Factor Receptor Superfamily, Member 7; T-Cell Activation Antigen CD27; CD27L Receptor; CD27 Antigen; TNFRSF7; T14

• Gene ID
• 939

• UniProt ID
• P26842

• Long Name
• CD27 Molecule

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Phosphorylated.
  N-glycosylated.
  O-glycosylated with core 1 or possibly core 8 glycans.
  Glycosylation at Asn95 and Ser127
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect CD27_HUMAN (800)
  Glycosylation from GlyGen 4 sites, 3 N-linked glycans (1 site), 2 O-linked glycans (3 sites)

• Protein Refseq
• XP_011519344.1; XP_016875723.1; XP_047285856.1; XP_054229842.1; XP_054229843.1

• Function
• Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells.
  The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells.
  Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory.
  In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis.
  Negatively regulates the function of Th2 lymphocytes in the adipose tissue.

Select a product category from the dropdown menu below to view related products.