Mouse Anti-CD27 scFv-Fc Chimera (VS-0425-FY16)
CAT#: VS-0425-FY16
The anti-CD27 scFv-Fc is engineered to bind specifically to the CD27 receptor, which plays a critical role in T-cell activation and proliferation. By using an scFv-Fc format, this product achieves improved binding affinity and extended half-life in circulation, facilitating enhanced therapeutic performance. This monoclonal antibody fusion can be utilized in cancer treatments to promote T-cell responses or in immune modulation therapies to enhance immune system function. Its capacity to activate immune cells makes it a valuable tool for further research and clinical applications.







Specifications
- Immunogen
- The immunogen was a soluble human CD27-Fc fusion protein.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- The antibody binds to human CD27.
- Species Reactivity
- Human
- Applications
- Inhibition, ELISA, Flow Cytometry
- Related Disease
- Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- CD27 Molecule; Tumor Necrosis Factor Receptor Superfamily, Member 7; T-Cell Activation Antigen CD27; CD27L Receptor; CD27 Antigen; TNFRSF7; T14
- Gene ID
- 939
- UniProt ID
- P26842
- Long Name
- CD27 Molecule
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- Phosphorylated.
N-glycosylated.
O-glycosylated with core 1 or possibly core 8 glycans.
Glycosylation at Asn95 and Ser127
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect CD27_HUMAN (800)
Glycosylation from GlyGen 4 sites, 3 N-linked glycans (1 site), 2 O-linked glycans (3 sites)
- Protein Refseq
- XP_011519344.1; XP_016875723.1; XP_047285856.1; XP_054229842.1; XP_054229843.1
- Function
- Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells.
The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells.
Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory.
In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis.
Negatively regulates the function of Th2 lymphocytes in the adipose tissue.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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MOB-024LC | Rat Anti-CD27 Recombinant Antibody (clone CBLS-204) | FC, IHC | Rat IgG |
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CAT | Product Name | Application | Type |
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TAB-H74 | Human Anti-Human CD27 Recombinant Antibody (TAB-H74) | ELISA, IP, FC, FuncS, Neut, IF, ICC | IgG1 - kappa |
CAT | Product Name | Application | Type |
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TAB-013LC | Rat Anti-CD27 Recombinant Antibody (TAB-013LC) | ELISA, CDC, ADCC | Rat IgG2a |
TAB-014LC | Rat Anti-CD27 Recombinant Antibody (TAB-014LC) | ELISA, FC, CDC, ADCC | Rat IgG1 |
TAB-015LC | Rat Anti-CD27 Recombinant Antibody (TAB-015LC) | ELISA, FC, CDC, ADCC, SPR | Rat IgG2a |
TAB-016LC | Rat Anti-CD27 Recombinant Antibody (TAB-016LC) | ELISA, SPR | Rat IgG2b |
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CAT | Product Name | Application | Type |
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TAB-018LC | Human Anti-CD27 Recombinant Antibody (TAB-018LC) | ELISA | Chimeric antibody (rat/human) |
TAB-019LC | Human Anti-CD27 Recombinant Antibody (TAB-019LC) | ELISA | Chimeric antibody (rat/human) |
TAB-020LC | Human Anti-CD27 Recombinant Antibody (TAB-020LC) | ELISA | Chimeric antibody (rat/human) |
TAB-021LC | Human Anti-CD27 Recombinant Antibody (TAB-021LC) | ELISA | Chimeric antibody (rat/human) |
TAB-032LC | Anti-Human CD27 Recombinant Antibody (F14) | SPR, FC | Chimeric antibody (rabbit/human) |
CAT | Product Name | Application | Type |
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TAB-022LC | Human Anti-CD27 Recombinant Antibody (TAB-022LC) | ELISA | Humanized antibody |
TAB-023LC | Human Anti-CD27 Recombinant Antibody (TAB-023LC) | ELISA | Humanized antibody |
TAB-024LC | Human Anti-CD27 Recombinant Antibody (TAB-024LC) | ELISA, CDC, SPR | Humanized antibody |
TAB-025LC | Human Anti-CD27 Recombinant Antibody (TAB-025LC) | ELISA, FC, CDC, ADCC, SPR | Humanized antibody |
TAB-022LC-F(E) | Human Anti-CD27 Recombinant Antibody; Fab Fragment (TAB-022LC-F(E)) | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
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NEUT-320CQ | Hamster Anti-CD27 Recombinant Antibody (clone LG.7F9) | FC, FuncS, Neut | Hamster IgG |
NEUT-321CQ | Mouse Anti-CD27 Recombinant Antibody (NEUT-321CQ) | WB, Neut, FC | Mouse IgG1 |
NEUT-322CQ | Mouse Anti-CD27 Recombinant Antibody (clone CBL803) | WB, FC, CyTOF, Neut | Mouse IgG1 |
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MOR-0547 | Hi-Affi™ Rabbit Anti-CD27 Recombinant Antibody (clone DS547AB) | WB, IHC, ICC, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
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CAT | Product Name | Application | Type |
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HPAB-0299-CN-S(P) | Human Anti-CD27 Recombinant Antibody; scFv Fragment (HPAB-0299-CN-S(P)) | ELISA, FC, Block | Human scFv |
HPAB-0300-CN-S(P) | Human Anti-CD27 Recombinant Antibody; scFv Fragment (HPAB-0300-CN-S(P)) | ELISA, FC, Block | Human scFv |
HPAB-N0032-YC-S(P) | Human Anti-CD27 Recombinant Antibody; scFv Fragment (HPAB-N0032-YC-S(P)) | ELISA, FC | Human scFv |
CAT | Product Name | Application | Type |
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HPAB-0299-CN-F(E) | Human Anti-CD27 Recombinant Antibody; Fab Fragment (HPAB-0299-CN-F(E)) | ELISA, FC, Block | Human Fab |
HPAB-0300-CN-F(E) | Human Anti-CD27 Recombinant Antibody; Fab Fragment (HPAB-0300-CN-F(E)) | ELISA, FC, Block | Human Fab |
HPAB-N0032-YC-F(E) | Human Anti-CD27 Recombinant Antibody; Fab Fragment (HPAB-N0032-YC-F(E)) | ELISA, FC | Human Fab |
CAT | Product Name | Application | Type |
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AFC-TAB-H74 | Afuco™ Anti-CD27 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H74) | ELISA, IP, FC, FuncS, Neut, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
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VS-0424-XY51 | AbPlus™ Anti-CD27 Magnetic Beads (2F2) | IP, Protein Purification |
CAT | Product Name | Application | Type |
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VS-0924-YC108 | Rat Anti-CD27 Recombinant Antibody Hexamer (VS-0924-YC108), CDC Enhanced | ELISA, FC, CDC, ADCC | Antibody hexamer |
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CAT | Product Name | Application | Type |
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VS-0225-XY30 | CytoStream™ Mouse Anti-CD27 Recombinant Antibody (VS-0225-XY30) | FC, IHC | Mouse IgG1, kappa |
VS-0225-XY31 | CytoStream™ Mouse Anti-CD27 Recombinant Antibody (VS-0225-XY31) | FC | Mouse IgG1, kappa |
CAT | Product Name | Application | Type |
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VS-0425-YC688 | Recombinant Anti-CD27 Vesicular Antibody, EV Displayed (VS-0425-YC688) | ELISA, FC, Neut, Cell-uptake |
CAT | Product Name | Application | Type |
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VS-0525-XY1151 | Anti-Rat CD27 Immunohistochemistry Kit | IHC |
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