Mouse Anti-CD27 scFv-Fc Chimera (VS-0425-FY16)

CAT#: VS-0425-FY16

The anti-CD27 scFv-Fc is engineered to bind specifically to the CD27 receptor, which plays a critical role in T-cell activation and proliferation. By using an scFv-Fc format, this product achieves improved binding affinity and extended half-life in circulation, facilitating enhanced therapeutic performance. This monoclonal antibody fusion can be utilized in cancer treatments to promote T-cell responses or in immune modulation therapies to enhance immune system function. Its capacity to activate immune cells makes it a valuable tool for further research and clinical applications.

Gene Expression
Figure 1 Lymph node Figure 2 Tonsil Figure 3 High expression in lymph node. Figure 4 Lymph node Figure 5 Tonsil Figure 6 RNA cell line category: Group enriched (Daudi, U-698) Figure 3 RNA cell line category: Group enriched (Daudi, U-698)

Specifications

  • Immunogen
  • The immunogen was a soluble human CD27-Fc fusion protein.
  • Host Species
  • Mouse
  • Type
  • Mouse IgG1, scFv-Fc
  • Specificity
  • The antibody binds to human CD27.
  • Species Reactivity
  • Human
  • Applications
  • Inhibition, ELISA, Flow Cytometry
  • Related Disease
  • Lymphoproliferative Syndrome 2 and Autosomal Recessive Lymphoproliferative Disease

Product Property

  • Purity
  • >95% as determined by SDS-PAGE
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • The optimal dilution concentration is determined by the experiment.

Target

  • Alternative Names
  • CD27 Molecule; Tumor Necrosis Factor Receptor Superfamily, Member 7; T-Cell Activation Antigen CD27; CD27L Receptor; CD27 Antigen; TNFRSF7; T14
  • Long Name
  • CD27 Molecule
  • Cellular Localization
  • Cell membrane
  • Post Translation Modifications
  • Phosphorylated.
    N-glycosylated.
    O-glycosylated with core 1 or possibly core 8 glycans.
    Glycosylation at Asn95 and Ser127
    Modification sites at PhosphoSitePlus
    Glycosylation from GlyConnect CD27_HUMAN (800)
    Glycosylation from GlyGen 4 sites, 3 N-linked glycans (1 site), 2 O-linked glycans (3 sites)
  • Function
  • Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells.
    The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells.
    Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory.
    In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis.
    Negatively regulates the function of Th2 lymphocytes in the adipose tissue.
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

MSDS

COA

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