Mouse Anti-CD6 (clone IOR-T1) scFv-Fc Chimera
CAT#: VS-0425-FY90
Anti-CD6 scFv-Fc is a recombinant antibody targeting the CD6 co-stimulatory molecule found on T cells and some B cell subsets. The single-chain variable fragment (scFv) provides specific binding to CD6, while the Fc region offers stability, potential dimerization, and Fc-mediated effector functions. This format is being investigated for its potential to modulate T cell responses in autoimmune diseases and for research applications in lymphocyte biology.
Gene Expression
Normal Tissue
Figure 1 High expression in lymph node.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_8_8_val_selected.jpg
Normal Tissue
Figure 2 Low expression in cerebral cortex.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_B_8_5_val_selected.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Mucosal lymphoid cells Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_8_3.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_7_8.jpg
Normal Tissue
Figure 5 Tonsil
Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2489/6144_A_5_8.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (JURKAT, MOLT-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000013725-CD6
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG2a, scFv-Fc
- Specificity
- Human CD6
- Species Reactivity
- Human
- Clone
- IOR-T1
- Applications
- ELISA
- Related Disease
- Bronchus Cancer and Inflammatory Bowel Disease 16
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- CD6 Molecule; CD6 Antigen; TP120; T12; T-Cell Differentiation Antigen CD6
- Gene ID
- 923
- UniProt ID
- P30203
- Long Name
- CD6 Molecule
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues.
Glycosylated.
Glycosylation at Asn28, Asn49, Asn112, Asn118, Asn229, Asn368, Asn339, and Asn345
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 8 sites, 2 N-linked glycans (1 site)
- Protein Refseq
- XP_006718801.1; XP_006718802.1; XP_006718803.1; XP_011543662.1; XP_011543664.1
- Function
- Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166.
Contributes to signaling cascades triggered by activation of the TCR/CD3 complex.
Functions as a costimulatory molecule; promotes T-cell activation and proliferation.
Contributes to the formation and maturation of the immunological synapse.
Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria.
Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria.
LPS binding leads to the activation of signaling cascades and down-stream MAP kinases.
Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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