Mouse Anti-CD6 (clone IOR-T1) scFv-Fc Chimera (CAT#: VS-0425-FY90)

• Host Species
• Mouse

• Type
• Mouse IgG2a, scFv-Fc

• Specificity
• Human CD6

• Species Reactivity
• Human

• Clone
• IOR-T1

• Applications
• ELISA

• Related Disease
• Bronchus Cancer and Inflammatory Bowel Disease 16

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• CD6 Molecule; CD6 Antigen; TP120; T12; T-Cell Differentiation Antigen CD6

• Gene ID
• 923

• UniProt ID
• P30203

• Long Name
• CD6 Molecule

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues and phosphorylated on Tyr residues.
  Glycosylated.
  Glycosylation at Asn28, Asn49, Asn112, Asn118, Asn229, Asn368, Asn339, and Asn345
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 8 sites, 2 N-linked glycans (1 site)

• Protein Refseq
• XP_006718801.1; XP_006718802.1; XP_006718803.1; XP_011543662.1; XP_011543664.1

• Function
• Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166.
  Contributes to signaling cascades triggered by activation of the TCR/CD3 complex.
  Functions as a costimulatory molecule; promotes T-cell activation and proliferation.
  Contributes to the formation and maturation of the immunological synapse.
  Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria.
  Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria.
  LPS binding leads to the activation of signaling cascades and down-stream MAP kinases.
  Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS.

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