Recombinant Mouse Anti-CEA Soluble TCR () (KIH)

Name: Recombinant Mouse Anti-CEA Soluble TCR () (KIH)
SKU: VS-0622-YF5441
Rating: 5 (1 reviews)

CAT#: VS-0622-YF5441

Mouse TCR recognizes CEA peptide (IMIGVLVGV) in the context of HLA-A*0201. Soluble TCR is expressed with Knob-in-hole (KIH) strategy (scTCR-hIgG Knob, scTCR-hIgG Hole). Please note that the activity is not guaranteed.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line HaCaT

Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19758/1660_G5_2_selected.jpg

Subcellular Location Figure 2 IHC staining of human duodenum

Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in a subset of leukocytes.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11041/ihc_selected.jpg

Normal Tissue Figure 3 Colon

Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Gradient
Gradient: Ascending
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_7_3.jpg

Normal Tissue Figure 4 Rectum

Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_6_3.jpg

RNA Expression Figure 5 RNA cell line category: Cell line enriched (OE19)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105388-CEACAM5

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Specifications

Host Species
Mouse

Target
CEA

Species Reactivity
Human

Epitope
IMIGVLVGV

MHC
HLA-A*0201

Type
Soluble TCR (KIH)

Related Disease
Colorectal cancer

TCR Expression Strategy
KIH strategy: scTCR-human IgG Knob and scTCR-human IgG Hole can form heterodimer based on Knob-in-hole (KIH) strategy. The soluble TCR contains single chain TCR. With this KIH antibody production strategy, VL/VH will be replaced with Valpha-linker-Vbeta (single chain TCR).

Target

Alternative Names
CEA; CD66e; CEACAM5; carcinoembryonic antigen related cell adhesion molecule 5

Gene ID
1048

UniProt ID
P06731

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Datasheet

Datasheet - VS-0622-YF5441.pdf

MSDS

MSDS - VS-0622-YF5441.pdf

COA

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